Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys
Open accessAbstract
Bisphenol‐A (BPA) is widely used in the manufacture of plastics, epoxy resins, and certain paper products. A majority of the population in the developed world is routinely exposed to BPA from multiple sources and has significant circulating levels of BPA. Although BPA is categorized as an endocrine disruptor with a growing literature on adverse effects, it is uncertain whether cognitive dysfunction is induced in humans by exposure to BPA. The present study examined the impact of BPA in primate brain by exposing adult male vervet monkeys for 4 weeks continuously to circulating levels of BPA that were in the range measured in studies of humans environmentally exposed to BPA. This regimen of exposure to BPA decreased both working memory accuracy and the number of excitatory synaptic inputs on dendritic spines of pyramidal neurons in two brain regions that are necessary for working memory (prefrontal cortex and hippocampus). These observed behavioral and synaptic effects were ameliorated following withdrawal from BPA. As Old World monkeys (e.g., vervets) and humans share some uniquely primate morphological, endocrine, and cognitive traits, this study indicates the potential for significant cognitive disruption following exposure of humans to BPA. J. Comp. Neurol. 523:1248–1257, 2015. © 2015 Wiley Periodicals, Inc.
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A positive relationship between spine morphology and LTP induction has been demonstrated.
“A positive relationship between spine morphology and LTP induction has been demonstrated.14”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [14]
The Methods (Spine Synapses; page unavailable) describe counting asymmetric spine synapses, and the Discussion (page unavailable) links synapse number to working-memory performance. Searches for LTP induction, long-term potentiation, and potentiation found no passage addressing a relationship between spine morphology and LTP induction. (LLM, conf=0.76)
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Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms
Hu, F., Li, T., Gong, H., Chen, Z., Jin, Y., Xu, G., & Wang, M. (2017) · Advanced Science · doi:10.1002/advs.201600493 · Cited by 87 · see citing works
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- Authors
- Elsworth, J. D., Jentsch, J. D., Groman, S. M., Roth, R. H., Redmond, E. D., & Leranth, C.
- Affiliations
- Yale University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Elsworth, John D.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2015-02-17
- Volume
- 523
- Issue
- 8
- Pages
- 1248-1257
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC4390445
- OpenAlex
- W1543233888
- Cited by
- 51
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS056181, ES017013)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- bisphenol A, endocrine disruptors, cognitive impairment, working memory, dendritic spines, synaptic asymmetry, excitatory synapses, pyramidal neurons, dorsolateral prefrontal cortex, hippocampus, vervet monkey, environmental exposure, primate brain
- MeSH terms
- Bisphenol A Compounds, Air Pollutants, Occupational, Animals, Benzhydryl Compounds, Chlorocebus aethiops, Cognition Disorders, Environmental Exposure, Male, Memory, Short-Term, Microscopy, Electron, Neuropsychological Tests, Phenols, Synapses, Prefrontal Cortex, Pyramidal Cells, Models, Animal, Dendritic Spines, CA1 Region, Hippocampal
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