The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
A quantitative study of the human cerebellum with unbiased stereological techniques
Abstract
Estimates of total number of different neuron and glial cell types in the dentate nuclei and the four major regions of the human cerebellum were obtained by new stereological methods. With the optical disector and Cavalieri methods, the total number of neurons and glial cells in the human cerebellum of five elderly men was estimated to be 105,000 x 10(6) (coefficient of variation, CV = 0.13). Of this total, the granule cells comprised 101,000 x 10(6) (CV = 0.13) and the Purkinje cells comprised 30.5 x 10(6) (CV = 0.13) of the neurons. The mean of the total number of neurons in the dentate nucleus was 5.01 x 10(6) (CV = 0.28). The average surface area of the human cerebellum was estimated to be 1160 cm2 (CV = 0.29). The rationale for the different sampling schemes used to quantify the various cell types is described.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“With more recent estimates of 21–26 billion neurons in the cerebral cortex (Pelvig et al., 2008) and 101 billion neurons in the cerebellum (Andersen et al., 1992), however, the total number of neurons in the human brain would increase to over 120 billion neurons.”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Andersen et al., 1992
In the citing paper
“the only possible explanation for the ubiquitous quote of 10 times more glial than neuronal cells in the entire human brain would be the presence of nearly one trillion glial cells in the remaining structures alone – an unlikely scenario, since these structures represent <10% of total brain mass.”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Andersen et al., 1992
Citations
Cites
The efficiency of systematic sampling in stereology and its prediction*
Gundersen, H. J. G., & Jensen, E. B. V. (1987) · Journal of Microscopy · doi:10.1111/j.1365-2818.1987.tb02837.x · Cited by 3,519
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
GUNDERSEN, H. J. G., BENDTSEN, T. F., KORBO, L., MARCUSSEN, N., MØLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B., SØRENSEN, F. B., VESTERBY, A., et al. (1988) · APMIS · doi:10.1111/j.1699-0463.1988.tb05320.x · Cited by 2,929
Self-citationThe unbiased estimation of number and sizes of arbitrary particles using the disector
Sterio, D. C. (1984) · Journal of Microscopy · doi:10.1111/j.1365-2818.1984.tb02501.x · Cited by 2,533
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480
Self-citationPalay, S. L., & Chan‐Palay, V. (1974) · Springer eBooks · doi:10.1007/978-3-642-65581-4 · Cited by 2,468
Cerebellar Cortex: Cytology and Organization
Palay, S. L., & Chan‐Palay, V. (1974) · Medical Entomology and Zoology · Cited by 1,679
Gundersen, H. J. G. (1986) · PubMed · Cited by 1,658
Stereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444
Research works printed but not linked: 4
- Albrechtsen R.(1979)Akut selektiv nekrose i stratum granulare cerebelli(Thesis in Danish). Fadl's Forlag pp.1–63.
- Jansen J., 1958, Das Kleinhirn. Handbuch der Mikroskopischen Anatomie des Menschen, 91
- Lange W., 1982, Regional Differences in the Cytoarchitecture of the Cerebellar Cortex. Experimental Brain Research, 93
- Pakkenberg B., 1989, Total number of neurons in human neocortex related to age and sex estimated by way of optical disectors, Acta Stereol., 8, 251
Cited by
Sorted by citations
Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,652
Azevedo, F. A. C., Carvalho, L. R. B., Grinberg, L. T., Farfel, J. M., Ferretti, R. E. L., Leite, R. E. P., Filho, W. J., Lent, R., & Herculano‐Houzel, S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21974 · Cited by 2,337
The human brain in numbers: a linearly scaled-up primate brain
Herculano-Houzel, S. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.031.2009 · Cited by 1,778
“, 2008) and 101 billion neurons in the cerebellum (Andersen et al., 1992), however, the total number of neurons in the human brain would increase to over 120 billion neurons.”
InfluentialDiamond, A. D. (2000) · Child Development · doi:10.1111/1467-8624.00117 · Cited by 1,584
von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063
Metadata
- Authors
- Andersen, B. B., Korbo, L., & Pakkenberg, B.
- Affiliations
- Aarhus University (DK)
- Copenhagen Municipal Hospital (DK)
- ORCID
- Pakkenberg, Bente
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1992-12-22
- Volume
- 326
- Issue
- 4
- Pages
- 549-560
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2087923797
- Cited by
- 276
- References
- 37
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 18 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Applied Mathematics › Point processes and geometric inequalities
- Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Keywords
- human cerebellum, neuron number estimation, glial cells, dentate nucleus, granule cells, Purkinje cells, optical disector, Cavalieri method, stereology, cell number
- MeSH terms
- Cell Count, Cerebellum, Cytological Techniques, Granulocytes, Humans, Male, Neuroglia, Neurons, Purkinje Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
