Cited by 276Point processes and geometric inequalitiesClassical Anatomy and HistologyCell Image Analysis Techniques

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A quantitative study of the human cerebellum with unbiased stereological techniques

Andersen, Birgitte Bo, Korbo, Lise, Pakkenberg, Bente·1992·Journal of Comparative Neurology

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Abstract

Estimates of total number of different neuron and glial cell types in the dentate nuclei and the four major regions of the human cerebellum were obtained by new stereological methods. With the optical disector and Cavalieri methods, the total number of neurons and glial cells in the human cerebellum of five elderly men was estimated to be 105,000 x 10(6) (coefficient of variation, CV = 0.13). Of this total, the granule cells comprised 101,000 x 10(6) (CV = 0.13) and the Purkinje cells comprised 30.5 x 10(6) (CV = 0.13) of the neurons. The mean of the total number of neurons in the dentate nucleus was 5.01 x 10(6) (CV = 0.28). The average surface area of the human cerebellum was estimated to be 1160 cm2 (CV = 0.29). The rationale for the different sampling schemes used to quantify the various cell types is described.

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Authors: Andersen, B. B., Korbo, L., & Pakkenberg, B.
Affiliations: Aarhus University (DK)
Copenhagen Municipal Hospital (DK)
ORCID: Pakkenberg, Bente
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1992-12-22
Volume: 326
Issue: 4
Pages: 549-560
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903260405
OpenAlex: W2087923797
Cited by: 276
References: 37
Citations by year: 2026: 11 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 18 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 6
FWCI: 4.39
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4309 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Mathematics › Applied Mathematics › Point processes and geometric inequalities
Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Keywords: human cerebellum, neuron number estimation, glial cells, dentate nucleus, granule cells, Purkinje cells, optical disector, Cavalieri method, stereology, cell number
MeSH terms: Cell Count, Cerebellum, Cytological Techniques, Granulocytes, Humans, Male, Neuroglia, Neurons, Purkinje Cells

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A quantitative study of the human cerebellum with unbiased stereological techniques

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