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PHA-L analysis of projections from the supramammillary nucleus in the rat

Vertes, Robert P.·1992·Journal of Comparative Neurology

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Abstract

The projections of the supramammillary nucleus (SUM) were examined in the rat by the anterograde anatomical tracer Phaseolus vulgaris leucoagglutinin (PHA-L). The majority of labeled fibers from SUM ascended through the forebrain within the medial forebrain bundle. SUM fibers were found to terminate heavily in the hippocampal formation, specifically within the granule cell layer and immediately adjoining molecular layer of the dentate gyrus. In addition, SUM fibers were shown to distribute densely to several structures with strong connections with the hippocampus, namely, the nucleus reunions of the thalamus, the medial and lateral septum, the entorhinal cortex, and the endopiriform nucleus. SUM fibers were also shown to project significantly to several additional subcortical and cortical sites. The subcortical sites were the dorsal raphe nucleus, the midbrain central gray, the fields of Forel/zona incerta, the dorsomedial hypothalamic area, midline/intralaminar nuclei of the thalamus (posterior paraventricular, rhomboid, central medial, intermediodorsal, and mediodorsal), the medial and lateral preoptic areas, the bed nucleus of the stria terminalis, the substantia innominata, the vertical limb of the diagonal band nucleus, and the claustrum. The cortical sites were the occipital, temporal, parietal, and frontal cortices. Some notable differences were observed in projections from the lateral as compared to the medial SUM. For example, fibers originating from the lateral SUM distributed heavily to the hippocampal formation and parts of the cortex, whereas those from the medial SUM projected sparsely to these two regions. The SUM projections to the hippocampal formation and associated structures may serve as the substrate for a SUM involvement in the generation of the theta rhythm of the hippocampus and the gating of information flow through the hippocampal formation.

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Patrones de colateralizacion de los nucleos del rafe y del nucleo incertus al sistema septo-hipocampico
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Glutamatergic Supramammillary Nucleus Neurons Respond to Threatening Stressors and Promote Active CopingPreprint
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“From an anatomical perspective, the SuM can be subdivided into medial and lateral subregions, which differ in their cellular composition and in their efferent-afferent circuit organization(Pan and McNaughton, 2004; Vertes, 1992).”
A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memoryPreprint
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The functional anatomy of hippocampal theta and gamma oscillations
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“In addition to brainstem nuclei, hypothalamic nuclei, including the supramammilary nucleus, project predominantly to the dentate granule layer and inner third of the molecular layer (Vertes 1992).”
Background
Untitled work
Nakagawa (1999) · doi:10.1002/(sici)1096-9861(19990830)411:3
Untitled work
(1997) · doi:10.1002/(sici)1098-1063(1997)7:1
Untitled work
(1999) · doi:10.1002/(sici)1098-1063(1999)9:5

Authors: Vertes, R. P.
Affiliations: Florida Atlantic University (US)
Corresponding author: Vertes, Robert P.
ORCID: Vertes, Robert P.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1992-12-22
Volume: 326
Issue: 4
Pages: 595-622
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903260408
OpenAlex: W2029127832
Cited by: 299
References: 92
Citations by year: 2026: 11 · 2025: 4 · 2024: 9 · 2023: 14 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 7 · 2012: 11
FWCI: 3.82
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4309 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh045075-06)
National Institute of Mental Health (MH-45075)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: supramammillary nucleus, anterograde tracing, Phaseolus vulgaris leucoagglutinin, hippocampal formation, dentate gyrus, medial forebrain bundle, thalamic nuclei, septum, entorhinal cortex, endopiriform nucleus, dorsal raphe nucleus, thalamus, preoptic area, bed nucleus of the stria terminalis, substantia innominata, diagonal band of Brodmann, claustrum, theta oscillations
MeSH terms: Animals, Cerebral Cortex, Hippocampus, Male, Mammillary Bodies, Mesencephalon, Neural Pathways, Phytohemagglutinins, Prosencephalon, Rats, Sprague-Dawley, Rats

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PHA-L analysis of projections from the supramammillary nucleus in the rat

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