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SERS Microscopy: Nanoparticle Probes and Biomedical Applications

Schlücker, Sebastian·2009·ChemPhysChem

Abstract

Microspectroscopic imaging: Surface‐enhanced Raman scattering (SERS) microscopy is a novel method of vibrational microspectroscopic imaging for the selective detection of biomolecules in targeted research. This review summarizes current designs of nanoparticle‐based SERS probes (see figure) and highlights first biomedical applications of SERS microscopy for protein localization ex and in vivo.magnified image Surface‐enhanced Raman scattering (SERS) microscopy is a novel method of vibrational microspectroscopic imaging for the selective detection of biomolecules in targeted research. This technique combines the advantages of biofunctionalized metal nanoparticles and Raman microspectroscopy for visualizing and quantifying the distribution of target molecules such as proteins in cells and tissues. Advantages of SERS over existing labeling approaches include the tremendous multiplexing capacity, quantification using the characteristic SERS signatures and high photostability. This review summarizes current designs of nanoparticle‐based SERS probes and highlights first biomedical applications of SERS microscopy for protein localization ex and in vivo.

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Metadata

Authors
Schlücker, S.
Venue
ChemPhysChem
Publisher
Wiley
Published
2009-06-29
Volume
10
Issue
9-10
Pages
1344-1354
ISSN
  • 1439-4235 (ISSN-L)
  • 1439-7641
OpenAlex
W2039559580
Cited by
372
References
3
FWCI
11.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: SERS Microscopy: Nanoparticle Probes and Biomedical Applications. https://app.cochat.ai/papers/10.1002/cphc.200900119
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Schlücker, S. (2009). SERS Microscopy: Nanoparticle Probes and Biomedical Applications. ChemPhysChem. https://doi.org/10.1002/cphc.200900119

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