In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486 · see citing works

Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering

Nie, S., & Emory, S. R. (1997) · Science · doi:10.1126/science.275.5303.1102 · Cited by 10,260 · see citing works

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368 · see citing works

Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,794 · see citing works

Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)

Kneipp, K. D., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R., & Feld, M. S. (1997) · Physical Review Letters · doi:10.1103/physrevlett.78.1667 · Cited by 6,824 · see citing works

Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods

Huang, X., El‐Sayed, I. H., Qian, W. P., & El‐Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,442 · see citing works

In vivo cancer targeting and imaging with semiconductor quantum dots

Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,775 · see citing works

Nanostructures in Biodiagnostics

Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603 · see citing works

Cancer nanotechnology: opportunities and challenges

Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,961 · see citing works

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works

Surface-enhanced Raman scattering

Campion, A., & Kambhampati, P. (1998) · Chemical Society Reviews · doi:10.1039/a827241z · Cited by 3,404 · see citing works

The use of nanocrystals in biological detection

Alivisatos, A. P. (2003) · Nature Biotechnology · doi:10.1038/nbt927 · Cited by 3,006 · see citing works

Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection

Cao, Y. C., Jin, R. M., & Mirkin, C. A. (2002) · Science · doi:10.1126/science.297.5586.1536 · Cited by 2,977 · see citing works

Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots

Wu, X., Liu, H., Liu, J., Haley, K. N., Treadway, J. A., Larson, J., Ge, N., Peale, F., & Bruchez, M. P. (2002) · Nature Biotechnology · doi:10.1038/nbt764 · Cited by 2,506 · see citing works

Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science

Niemeyer, C. M. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20011119)40:22 · Cited by 2,448 · see citing works

Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity

Connor, E. E., Mwamuka, J. N., Gole, A. M., Murphy, C. J., & Wyatt, M. D. (2005) · Small · doi:10.1002/smll.200400093 · Cited by 2,406 · see citing works

Ultrasensitive Chemical Analysis by Raman Spectroscopy

Kneipp, K. D., Kneipp, H., Itzkan, I., Dasari, R. R., & Feld, M. S. (1999) · Chemical Reviews · doi:10.1021/cr980133r · Cited by 2,180 · see citing works

Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping

Kim, S., Lim, Y. T., Soltesz, E. G., Grand, A. M. D., Lee, J., Nakayama, A., Parker, J. A., Mihaljevic, T., Laurence, R. G., Dor, D. M., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt920 · Cited by 2,087 · see citing works

Noninvasive detection of clinically occult lymph-node metastases in prostate cancer

Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971 · see citing works

Polymer conjugates as anticancer nanomedicines

Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956 · see citing works

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works

Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging

Zhang, H. F., Maslov, K., Stoica, G., & Wang, L. V. (2006) · Nature Biotechnology · doi:10.1038/nbt1220 · Cited by 1,855 · see citing works

Biocompatibility of Gold Nanoparticles and Their Endocytotic Fate Inside the Cellular Compartment: A Microscopic Overview

Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,689 · see citing works

Looking and listening to light: the evolution of whole-body photonic imaging

Ntziachristos, V., Ripoll, J., Wang, L. V., & Weissleder, R. (2005) · Nature Biotechnology · doi:10.1038/nbt1074 · Cited by 1,557 · see citing works

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

Liu, Z., Cai, W., He, L., Nakayama-Ratchford, N., Chen, K., Sun, X., Chen, X. S., & Dai, H. (2006) · Nature Nanotechnology · doi:10.1038/nnano.2006.170 · Cited by 1,440 · see citing works

Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals

Michaels, A. M., Nirmal, M., & Brus, L. E. (1999) · Journal of the American Chemical Society · doi:10.1021/ja992128q · Cited by 1,321 · see citing works

Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy

Gobin, A. M., Lee, M. H., Halas, N. J., James, W. D., Drezek, R. A., & West, J. L. (2007) · Nano Letters · doi:10.1021/nl070610y · Cited by 1,316 · see citing works

In vivo molecular and cellular imaging with quantum dots

Gao, X., Yang, L. P. H., Petros, J. A., Marshall, F. F., Simons, J. W., & Nie, S. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.11.003 · Cited by 1,213 · see citing works

Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery

Paciotti, G. F., Myer, L. D., Weinreich, D. M., Goia, D. V., Pavel, N., McLaughlin, R. E., & Tamarkin, L. (2004) · Drug Delivery · doi:10.1080/10717540490433895 · Cited by 1,184 · see citing works

Nanotechnology Applications in Cancer

Nie, S., Xing, Y., Gloria, K., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 1,125 · see citing works

Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging

Ntziachristos, V., Bremer, C., & Weissleder, R. (2003) · European Radiology · doi:10.1007/s00330-002-1524-x · Cited by 983 · see citing works

Nanotechnology: Intelligent Design to Treat Complex Disease

Couvreur, P., & Vauthier, C. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0284-8 · Cited by 950 · see citing works

Cell-specific targeting of nanoparticles by multivalent attachment of small molecules

Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 898 · see citing works

Tumor Regression by Targeted Gene Delivery to the Neovasculature

Hood, J. D., Bednarski, M. D., Frausto, R. F., Guccione, S., Reisfeld, R. A., Xiang, R., & Cheresh, D. A. (2002) · Science · doi:10.1126/science.1070200 · Cited by 858 · see citing works

In vivo imaging of siRNA delivery and silencing in tumors

Medarova, Z., Pham, W., Farrar, C., Petkova, V., & Moore, A. (2007) · Nature Medicine · doi:10.1038/nm1486 · Cited by 697 · see citing works

Transport of Molecules, Particles, and Cells in Solid Tumors

Jain, R. K. (1999) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.1.1.241 · Cited by 691 · see citing works

Polymeric micelle for tumor pH and folate-mediated targeting

Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620 · see citing works

Emerging use of nanoparticles in diagnosis and treatment of breast cancer

Yezhelyev, M. V., Gao, X., Xing, Y., Al-Hajj, A., Nie, S., & O'Regan, R. M. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70793-8 · Cited by 579 · see citing works

Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry

Xing, Y., Chaudry, Q., Shen, C., Kong, K. Y., Zhau, H. E., Chung, L. W. K., Petros, J. A., O'Regan, R. M., Yezhelyev, M. V., Simons, J. W., et al. (2007) · Nature Protocols · doi:10.1038/nprot.2007.107 · Cited by 528 · see citing works

Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors

Paciotti, G. F., Kingston, D. G. I., & Tamarkin, L. (2006) · Drug Development Research · doi:10.1002/ddr.20066 · Cited by 481 · see citing works

Spectroscopic Tags Using Dye-Embedded Nanoparticles and Surface-Enhanced Raman Scattering

Doering, W. E., & Nie, S. (2003) · Analytical Chemistry · doi:10.1021/ac034672u · Cited by 469 · see citing works

Monoclonal antibodies to target epidermal growth factor receptor–positive tumors

Herbst, R. S., & Shin, D. M. (2002) · Cancer · doi:10.1002/cncr.10372 · Cited by 449 · see citing works

Nanometer Gold Clusters Protected by Surface-Bound Monolayers of Thiolated Poly(ethylene glycol) Polymer Electrolyte

Wuelfing, W. P., Gross, S. M., Miles, D. T., & Murray, R. W. (1998) · Journal of the American Chemical Society · doi:10.1021/ja983183m · Cited by 407 · see citing works

Efficient Raman Enhancement and Intermittent Light Emission Observed in Single Gold Nanocrystals

Krug, J. T., Wang, G. D., Emory, S. R., & Nie, S. (1999) · Journal of the American Chemical Society · doi:10.1021/ja992058n · Cited by 353 · see citing works

Targeted Delivery of Multifunctional Magnetic Nanoparticles

McCarthy, J. R., Kelly, K. A., Sun, E. Y., & Weissleder, R. (2007) · Nanomedicine · doi:10.2217/17435889.2.2.153 · Cited by 254 · see citing works

Quantum Dots and Multifunctional Nanoparticles: New Contrast Agents for Tumor Imaging

Rhyner, M. N., Smith, A. M., Gao, X., Mao, H. Z., Yang, L. P. H., & Nie, S. (2006) · Nanomedicine · doi:10.2217/17435889.1.2.209 · Cited by 251 · see citing works

Study of Molecular Junctions with a Combined Surface-Enhanced Raman and Mechanically Controllable Break Junction Method

Tian, J., Liu, B., Li, Yang, Z., Ren, B. W., Wu, S., -, T., & Tian, Z. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0648615 · Cited by 209 · see citing works

Gold, the Noble Metal and the Paradoxes of its Toxicology

Merchant, B. (1998) · Biologicals · doi:10.1006/biol.1997.0123 · Cited by 202 · see citing works

Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering

Moore, B. D., Stevenson, L., Watt, A. P., Flitsch, S. L., Turner, N. J., Cassidy, C., & Graham, D. (2004) · Nature Biotechnology · doi:10.1038/nbt1003 · Cited by 200 · see citing works

Application of INAA to the build-up and clearance of gold nanoshells in clinical studies in mice

James, W. D., Hirsch, L. R., West, J. L., O’Neal, P. D., & Payne, J. D. (2006) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-007-0230-1 · Cited by 183 · see citing works

Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck

Reuter, C. W., Morgan, M. A., & Eckardt, A. M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603566 · Cited by 114 · see citing works

The distribution and radiation effects of intravenously administered colloidal Au198 in man

Root, S. W., Andrews, G. A., Kniseley, R. M., & Tyor, M. P. (1954) · Cancer · doi:10.1002/1097-0142(195409)7:5 · Cited by 72 · see citing works

Resonant Raman Scattering by Crystal-Violet Molecules Adsorbed on a Smooth Gold Surface: Evidence for a Charge-Transfer Excitation

Jiang, J. D., Burstein, E., & Kobayashi, H. (1986) · Physical Review Letters · doi:10.1103/physrevlett.57.1793 · Cited by 35 · see citing works

Nanoparticles deliver RNAi therapy

Woodle, M. C., & Lu, P. Y. (2005) · Materials Today · doi:10.1016/s1369-7021(05)71035-x · Cited by 22 · see citing works

Understanding biophysicochemical interactions at the nano–bio interface

Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083 · see citing works

Gold Nanoparticles in Chemical and Biological Sensing

Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,637 · see citing works

Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works

Present and Future of Surface-Enhanced Raman Scattering

Langer, J., de Aberasturi, D. J., Aizpurua, J., Álvarez‐Puebla, R. A., Auguié, B., Baumberg, J. J., Bazan, G. C., Bell, S. E. J., Boisen, A., Brolo, A. G., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b04224 · Cited by 3,910 · see citing works

The golden age: gold nanoparticles for biomedicine

Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El‐Sayed, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15237h · Cited by 3,572 · see citing works

Shell-isolated nanoparticle-enhanced Raman spectroscopy

Li, J. F., Huang, Y. F., Ding, Y., Yang, Z. L., Li, S. B., Zhou, X. S., Fan, F. R., Zhang, W., Zhou, Z. Y., Wu, D. Y., et al. (2010) · Nature · doi:10.1038/nature08907 · Cited by 3,559 · see citing works

Near-infrared fluorophores for biomedical imaging

Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,013 · see citing works

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

Boisselier, É., & Astruc, D. (2009) · Chemical Society Reviews · doi:10.1039/b806051g · Cited by 2,832 · see citing works

Controlling the Synthesis and Assembly of Silver Nanostructures for Plasmonic Applications

Rycenga, M., Cobley, C. M., Zeng, J., Li, W., Moran, C. H., Zhang, Q., Qin, D., & Younan Xia, A. (2011) · Chemical Reviews · doi:10.1021/cr100275d · Cited by 2,832 · see citing works

Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications

Schlücker, S. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201205748 · Cited by 2,427 · see citing works

Gold Nanoparticles for Biology and Medicine

Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356 · see citing works

Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy

Huang, X., & El‐Sayed, M. A. (2010) · Journal of Advanced Research · doi:10.1016/j.jare.2010.02.002 · Cited by 2,202 · see citing works

Nanoparticle PEGylation for Imaging and Therapy

Jokerst, J. V., Lobovkina, T., Zare, R. N., & Gambhir, S. S. (2011) · Nanomedicine · doi:10.2217/nnm.11.19 · Cited by 2,054 · see citing works

Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications

Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,923 · see citing works

Nanostructure-based plasmon-enhanced Raman spectroscopy for surface analysis of materials

Ding, S., Yi, J., Li, J., Ren, B. W., Wu, D., Panneerselvam, R., & Tian, Z. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.21 · Cited by 1,835 · see citing works

Biological applications of gold nanoparticles

Sperling, R. A., Rivera-Gil, P., Zhang, F., Zanella, M., & Parak, W. J. (2008) · Chemical Society Reviews · doi:10.1039/b712170a · Cited by 1,808 · see citing works

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

Perrault, S. D., Walkey, C., Jennings, T. L., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,516 · see citing works

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,507 · see citing works

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

Alkilany, A. M., & Murphy, C. J. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-9911-8 · Cited by 1,493 · see citing works

Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology

Sapsford, K. E., Algar, W. R., Berti, L., Gemmill, K. B., Casey, B. J., Oh, E., Stewart, M. H., & Medintz, I. L. (2013) · Chemical Reviews · doi:10.1021/cr300143v · Cited by 1,429 · see citing works

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,394 · see citing works

Localized surface plasmon resonance: Nanostructures, bioassays and biosensing—A review

Petryayeva, E., & Krull, U. J. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.08.020 · Cited by 1,387 · see citing works

Quantum Dots and Their Multimodal Applications: A Review

Bera, D., Qian, L., Tseng, T.-K., & Holloway, P. H. (2010) · Materials · doi:10.3390/ma3042260 · Cited by 1,365 · see citing works

Diverse Applications of Nanomedicine

Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350 · see citing works

Gold nanoparticles: preparation, properties, and applications in bionanotechnology

Yeh, Y., Creran, B., & Rotello, V. M. (2011) · Nanoscale · doi:10.1039/c1nr11188d · Cited by 1,348 · see citing works

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

Wang, Y., Yan, B., & Chen, L. (2012) · Chemical Reviews · doi:10.1021/cr300120g · Cited by 1,336 · see citing works

Using Raman spectroscopy to characterize biological materials

Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.036 · Cited by 1,309 · see citing works

Gold Nanomaterials at Work in Biomedicine

Yang, X., Yang, M., Pang, B., Vara, M., & Younan Xia, A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,169 · see citing works

Physical Principles of Nanoparticle Cellular Endocytosis

Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,148 · see citing works

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

James, M. L., & Gambhir, S. S. (2012) · Physiological Reviews · doi:10.1152/physrev.00049.2010 · Cited by 1,145 · see citing works

Highly uniform and reproducible surface-enhanced Raman scattering from DNA-tailorable nanoparticles with 1-nm interior gap

Lim, D., Jeon, K.-S., Hwang, J.-H., Kim, H., Kwon, S., Suh, Y. D., & Nam, J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.79 · Cited by 1,138 · see citing works

Core–Shell Nanoparticle-Enhanced Raman Spectroscopy

Li, J., Zhang, Y., Ding, S., Panneerselvam, R., & Tian, Z. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00596 · Cited by 1,137 · see citing works

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

Doane, T. L., & Burda, C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15260f · Cited by 1,100 · see citing works

Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications

Qian, X.-M., & Nie, S. (2008) · Chemical Society Reviews · doi:10.1039/b708839f · Cited by 1,100 · see citing works

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088 · see citing works

A review on the fabrication of substrates for surface enhanced Raman spectroscopy and their applications in analytical chemistry

Fan, M., Andrade, G. F. S., & Brolo, A. G. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.03.002 · Cited by 1,048 · see citing works

Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas

von Maltzahn, G., Park, J., Agrawal, A., Bandaru, N. K., Das, S. K., Sailor, M. J., & Bhatia, S. N. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4242 · Cited by 1,047 · see citing works

Introduction to metallic nanoparticles

Mody, V. V., Siwale, R. C., Singh, A. V., & Mody, H. (2010) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.72127 · Cited by 1,045 · see citing works

A Review on Surface-Enhanced Raman Scattering

Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., & Fabris, L. (2019) · Biosensors · doi:10.3390/bios9020057 · Cited by 1,030 · see citing works

Plasmon-enhanced optical sensors: a review

Li, M., Cushing, S. K., & Wu, N. (2014) · The Analyst · doi:10.1039/c4an01079e · Cited by 1,015 · see citing works

Chemistry, Biology, and Medicine of Fluorescent Nanomaterials and Related Systems: New Insights into Biosensing, Bioimaging, Genomics, Diagnostics, and Therapy

Yao, J., Yang, M., & Duan, Y. (2014) · Chemical Reviews · doi:10.1021/cr200359p · Cited by 948 · see citing works

Nanomedicine in cancer therapy

Fan, D., Cao, Y., Cao, M., Wang, Y., Cao, Y., & Gong, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01536-y · Cited by 944 · see citing works

Surface-enhanced Raman spectroscopy

Han, X., Rodriguez, R. S., Haynes, C. L., Ozaki, Y., & Zhao, B. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00083-6 · Cited by 935 · see citing works

Assessment of the Evolution of Cancer Treatment Therapies

Arruebo, M., Vilaboa, N. E., Sáez, B., Lambea, J., Tres, A., Valladares, M., & González‐Fernández, Á. (2011) · Cancers · doi:10.3390/cancers3033279 · Cited by 932 · see citing works

SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging

Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873 · see citing works

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

Tenzer, S., Docter, D., Rosfa, S., Wlodarski, A., Kuharev, J., Rekik, A., Knauer, S. K., Bantz, C., Nawroth, T., Bier, C., et al. (2011) · ACS Nano · doi:10.1021/nn201950e · Cited by 854 · see citing works

Applications of gold nanoparticles in cancer nanotechnology

Cai, W. (2008) · Nanotechnology Science and Applications · doi:10.2147/nsa.s3788 · Cited by 850 · see citing works

Multifunctional nanoparticles – properties and prospects for their use in human medicine

Sanvicens, N., & Marco, M. ‐. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.04.005 · Cited by 831 · see citing works

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. S. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 819 · see citing works

Strategies for the intracellular delivery of nanoparticles

Chou, L. Y. T., Ming, K., & Chan, W. C. W. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00003e · Cited by 813 · see citing works

Nanostructured Surfaces and Assemblies as SERS Media

Ko, H., Singamaneni, S., & Tsukruk, V. V. (2008) · Small · doi:10.1002/smll.200800337 · Cited by 785 · see citing works

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

Wang, Y., Zhou, K., Huang, G., Hensley, C. T., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2013) · Nature Materials · doi:10.1038/nmat3819 · Cited by 776 · see citing works

Design considerations for tumour-targeted nanoparticles

Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754 · see citing works

Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

Cheng, Y., Samia, A. C. S., Meyers, J. D., Panagopoulos, I., Fei, B., & Burda, C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801631c · Cited by 733 · see citing works

Gold nanoparticle-enabled biological and chemical detection and analysis

Jans, H., & Huo, Q. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15280g · Cited by 723 · see citing works

The cytotoxicity of cadmium-based quantum dots

Chen, N., He, Y., Su, Y., Li, X., Huang, Q., Wang, H., Zhang, X., Tai, R., & Fan, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.070 · Cited by 722 · see citing works

Multifunctional Gold Nanoparticles for Diagnosis and Therapy of Disease

Mieszawska, A. J., Mulder, W. J. M., Fayad, Z. A., & Cormode, D. P. (2013) · Molecular Pharmaceutics · doi:10.1021/mp3005885 · Cited by 719 · see citing works

Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy

Zavaleta, C. L., Smith, B. R., Walton, I., Doering, W., Davis, G., Shojaei, B., Natan, M. J., & Gambhir, S. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813327106 · Cited by 714 · see citing works

Noble Metal Nanoparticles for Biosensing Applications

Dória, G., Conde, J., Veigas, B., Giestas, L., Almeida, C., Assunção, M., Rosa, J., & Baptista, P. V. (2012) · Sensors · doi:10.3390/s120201657 · Cited by 713 · see citing works

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708 · see citing works

Electrochemical surface-enhanced Raman spectroscopy of nanostructures

Wu, D., Li, J., Ren, B. W., & Tian, Z. (2008) · Chemical Society Reviews · doi:10.1039/b707872m · Cited by 694 · see citing works

Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology

Cheon, J., & Lee, J.-H. (2008) · Accounts of Chemical Research · doi:10.1021/ar800045c · Cited by 684 · see citing works

Gated Tunability and Hybridization of Localized Plasmons in Nanostructured Graphene

Fang, Z., Thongrattanasiri, S., Schlather, A. E., Liu, Z., Ma, L., Wang, Y., Ajayan, P. M., Nordlander, P. J., Halas, N. J., & de Abajo, F. J. G. (2013) · ACS Nano · doi:10.1021/nn3055835 · Cited by 683 · see citing works

Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

Cho, W., Cho, M., Jeong, J., Choi, M., Cho, H., Han, B. S., Kim, S. H., Kim, H. O., Lim, Y. T., Chung, B. H., et al. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.12.023 · Cited by 657 · see citing works

Size Matters: Gold Nanoparticles in Targeted Cancer Drug Delivery

Dreaden, E. C., Austin, L. A., Mackey, M. A., & El‐Sayed, M. A. (2012) · Therapeutic Delivery · doi:10.4155/tde.12.21 · Cited by 656 · see citing works

Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

McNay, G., Eustace, D., Smith, W. E., Faulds, K., & Graham, D. (2011) · Applied Spectroscopy · doi:10.1366/11-06365 · Cited by 656 · see citing works

Nano‐Sized CT Contrast Agents

Lee, N., Choi, S. H., & Hyeon, T. (2013) · Advanced Materials · doi:10.1002/adma.201300081 · Cited by 656 · see citing works

Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual‐Targeted Photothermal Therapy

Cheng, L., Yang, K., Li, Y., Chen, J., Wang, C., Shao, M., Lee, S., & Liu, Z. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201101447 · Cited by 651 · see citing works

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

Sykes, E. A., Chen, J., Zheng, G., & Chan, W. C. W. (2014) · ACS Nano · doi:10.1021/nn500299p · Cited by 635 · see citing works

The Synthesis of SERS-Active Gold Nanoflower Tags for In Vivo Applications

Xie, J., Zhang, Q., Lee, J. Y., & Wang, D. I. C. (2008) · ACS Nano · doi:10.1021/nn800442q · Cited by 624 · see citing works

Inorganic nanoparticles for cancer imaging and therapy

Huang, H., Barua, S., Sharma, G., Dey, S. K., & Rege, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.004 · Cited by 620 · see citing works

Recent progress in SERS biosensing

Bantz, K. C., Meyer, A. F., Wittenberg, N. J., Im, H., Kurtuluş, Ö., Lee, S. H., Lindquist, N. C., Oh, S., & Haynes, C. L. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp01841d · Cited by 616 · see citing works

SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and Applications

Wang, Z., Zong, S., Wu, L., Zhu, D., & Cui, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00027 · Cited by 614 · see citing works

Drug‐Loaded Superparamagnetic Iron Oxide Nanoparticles for Combined Cancer Imaging and Therapy In Vivo

Yu, M. K., Jeong, Y. Y., Park, J., Park, S.-J., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 613 · see citing works

Functional nanoprobes for ultrasensitive detection of biomolecules

Song, S., Qin, Y., He, Y., Huang, Q., Fan, C., & Chen, H. (2010) · Chemical Society Reviews · doi:10.1039/c000682n · Cited by 591 · see citing works

Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications

Biju, V., Itoh, T., Anas, A., Sujith, A., & Ishikawa, M. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2185-7 · Cited by 578 · see citing works

Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice

Zhang, G., Yang, Z. H., Lü, W., Zhang, R., Huang, Q., Tian, M., Li, L., Liang, D., & Li, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.038 · Cited by 565 · see citing works

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K., & Chen, X. S. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 557 · see citing works

Noble Metal Nanoparticles Applications in Cancer

Conde, J., Dória, G., & Baptista, P. V. (2011) · Journal of Drug Delivery · doi:10.1155/2012/751075 · Cited by 547 · see citing works

Application of gold nanoparticles in biomedical and drug delivery

Daraee, H., Eatemadi, A., Abbasi, E., Aval, S. F., Kouhi, M., & Akbarzadeh, A. (2014) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2014.955107 · Cited by 545 · see citing works

Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

Bao, G., Mitragotri, S., & Tong, S. (2013) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071812-152409 · Cited by 537 · see citing works

(Intra)Cellular Stability of Inorganic Nanoparticles: Effects on Cytotoxicity, Particle Functionality, and Biomedical Applications

Soenen, S. J., Parak, W. J., Rejman, J., & Manshian, B. B. (2015) · Chemical Reviews · doi:10.1021/cr400714j · Cited by 520 · see citing works

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506 · see citing works

Surface analysis using shell-isolated nanoparticle-enhanced Raman spectroscopy

Li, J., Tian, X. D., Li, S. B., Anema, J. R., Yang, Z., Ding, Y. L., Wu, Y., Zeng, Y. M., Chen, Q. Z., Ren, B. W., et al. (2012) · Nature Protocols · doi:10.1038/nprot.2012.141 · Cited by 494 · see citing works

Hollow luminescent carbon dots for drug delivery

Wang, Q., Huang, X., Long, Y., Wang, X., Zhang, H., Zhu, R., Liang, L., Teng, P., & Zheng, H. (2013) · Carbon · doi:10.1016/j.carbon.2013.03.009 · Cited by 493 · see citing works

PET/NIRF/MRI triple functional iron oxide nanoparticles

Xie, J., Chen, K., Huang, J., Lee, S., Wang, J., Gao, J., Li, X., & Chen, X. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.010 · Cited by 492 · see citing works

Engineering metallic nanostructures for plasmonics and nanophotonics

Lindquist, N. C., Nagpal, P., McPeak, K. M., Norris, D. J., & Oh, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/3/036501 · Cited by 491 · see citing works

Hybrid Nanoparticles for Detection and Treatment of Cancer

Sailor, M. J., & Park, J. (2012) · Advanced Materials · doi:10.1002/adma.201200653 · Cited by 487 · see citing works

Monolayer coated gold nanoparticles for delivery applications

Rana, S., Bajaj, A., Mout, R., & Rotello, V. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.08.006 · Cited by 482 · see citing works

Noble Metal Coated Single-Walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy

Wang, X., Wang, C., Cheng, L., Lee, S., & Liu, Z. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300140c · Cited by 468 · see citing works

Engineering tailored nanoparticles with microbes: quo vadis ?

Prasad, R., Pandey, R., & Barman, I. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1363 · Cited by 467 · see citing works

SERS‐Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near‐Infrared Imaging and Photothermal Heating

von Maltzahn, G., Centrone, A., Park, J., Ramanathan, R., Sailor, M. J., Hatton, T. A., & Bhatia, S. N. (2009) · Advanced Materials · doi:10.1002/adma.200803464 · Cited by 457 · see citing works

Nanocarriers for drug delivery applications

Chamundeeswari, M., Jeslin, J., & Verma, M. L. (2018) · Environmental Chemistry Letters · doi:10.1007/s10311-018-00841-1 · Cited by 457 · see citing works

Probing Liquid/Solid Interfaces at the Molecular Level

Zaera, F. (2012) · Chemical Reviews · doi:10.1021/cr2002068 · Cited by 456 · see citing works

Plasmon-Controlled Fluorescence: Beyond the Intensity Enhancement

Ming, T., Chen, H., Jiang, R., Li, Q., & Wang, J. (2011) · The Journal of Physical Chemistry Letters · doi:10.1021/jz201392k · Cited by 451 · see citing works

Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis

Feng, S., Chen, R., Lin, J., Pan, J., Chen, G., Li, Y., Cheng, M., Huang, Z., Chen, J., & Zeng, H. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.03.033 · Cited by 448 · see citing works

In vivo degeneration and the fate of inorganic nanoparticles

Feliu, N., Docter, D., Heine, M., del Pino, P., Ashraf, S., Kolosnjaj‐Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00699f · Cited by 441 · see citing works

Surface-enhanced Raman spectroscopy for in vivo biosensing

Laing, S., Jamieson, L. E., Faulds, K., & Graham, D. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0060 · Cited by 441 · see citing works

Novel nanostructures for SERS biosensing

Tripp, R. A., Dluhy, R. A., & Zhao, Y. (2008) · Nano Today · doi:10.1016/s1748-0132(08)70042-2 · Cited by 440 · see citing works

Self-Assembled Plasmonic Vesicles of SERS-Encoded Amphiphilic Gold Nanoparticles for Cancer Cell Targeting and Traceable Intracellular Drug Delivery

Song, J., Zhou, J., & Duan, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305154a · Cited by 438 · see citing works

Spectrally Encoded SERS Nanoparticles for Multiplexed Optical Detection and Image-Guided Surgery

Nie, S., & Qian, X. (2013) · International Photonics and Optoelectronics Meetings · doi:10.1364/n3.2013.nsa2c.1 · Cited by 1 · see citing works

Two-step PEG-based surface functionalization of gold nanoparticles enables specific SERS imaging of EGFR in an ovarian cancer cell model

Stumpo, A., Coelho, R., López, M. N., Kind, L., Roo, J. D., Jacob, F., & Saxer, S. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103602

Surface-Enhanced Raman Nanoparticles for in-vivo Tumor Targeting and Spectroscopic Detection

Qian, X., Nie, S., Champion, P. M., & Ziegler, L. D. (2010) · AIP conference proceedings · doi:10.1063/1.3482831 · Cited by 6 · see citing works

Multi-color raman nanotags for tumor cell biomarker detection

Nyagilo, J. O., Xiao, M., Sun, X., & Davé, D. P. (2009) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2009.5332780 · Cited by 5 · see citing works

In vivo and ex vivo applications of gold nanoparticles for biomedical SERS imagingi.

Yigit, M. V., & Medarova, Z. O. (2012) · Europe PMC (PubMed Central) · Cited by 46 · see citing works