The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Biomarkers—A General Review
Abstract
A biomarker is a biological observation that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is more difficult to observe. The use of clinical biomarkers is easier and less expensive than direct measurement of the final clinical endpoint, and biomarkers are usually measured over a shorter time span. They can be used in disease screening, diagnosis, characterization, and monitoring; as prognostic indicators; for developing individualized therapeutic interventions; for predicting and treating adverse drug reactions; for identifying cell types; and for pharmacodynamic and dose‐response studies. To understand the value of a biomarker, it is necessary to know the pathophysiological relationship between the biomarker and the relevant clinical endpoint. Good biomarkers should be measurable with little or no variability, should have a sizeable signal to noise ratio, and should change promptly and reliably in response to changes in the condition or its therapy. © 2017 by John Wiley & Sons, Inc.
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Cites
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
(2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,762
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A Randomized Trial of Genotype-Guided Dosing of Warfarin
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Fundamentals of Clinical Trials
Rhoads, G. G. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380080101043 · Cited by 342
When can a risk factor be used as a worthwhile screening test?
Wald, N. J., Hackshaw, A. K., & Frost, C. D. (1999) · BMJ · doi:10.1136/bmj.319.7224.1562 · Cited by 341
Biomarkers and surrogate endpoints
Aronson, J. K. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02435.x · Cited by 312
Self-citationGilbert, R., Salanti, G., Harden, M., & See, S. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi088 · Cited by 261
Surrogate endpoints in clinical trials: Cardiovascular diseases
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Cited by
A Clinical Update on Gestational Diabetes Mellitus
Sweeting, A., Wong, J., Murphy, H. R., & Ross, G. P. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac003 · Cited by 928
Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council
Renert-Yuval, Y., Thyssen, J. P., Bissonnette, R., Bieber, T., Kabashima, K., Hijnen, D., & Guttman-Yassky, E. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.01.013 · Cited by 350
Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331
Bodaghi, A., Fattahi, N., & Ramazani, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13323 · Cited by 336
RetractedBlood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review
Santos, F., Cabreira, V., Rocha, S., & Massano, J. (2023) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887221141651 · Cited by 24
Metadata
- Authors
- Aronson, J. K., & Ferner, R. E.
- Venue
- Current Protocols in Pharmacology
- Publisher
- Wiley
- Published
- 2017-03
- Volume
- 76
- Issue
- 1
- Pages
- 9.23.1-9.23.17
- ISSN
- 1934-8282 (ISSN-L)
- 1934-8290
- OpenAlex
- W2600611927
- Cited by
- 417
- References
- 34
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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