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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing
Abstract
Tacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose‐adjusted trough concentrations of tacrolimus as compared with those who are CYP3A5 nonexpressers (poor metabolizers), possibly delaying achievement of target blood concentrations. We summarize evidence from the published literature supporting this association and provide dosing recommendations for tacrolimus based on CYP3A5 genotype when known (updates at www.pharmgkb.org ).
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“There is a high degree of sequence homology between CYP3A4 and CYP3A5, resulting in overlapping substrate specificity [37].”
From Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride (2023) · cites this paper as [37]
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Cited by
Andrews, L. M., Li, Y., De Winter, B. C. M., Shi, Y.-Y., Baan, C. C., Van Gelder, T., & Hesselink, D. A. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1395413 · Cited by 142
Zhang, Y., Wang, Z., Wang, Y., Jin, W., Zhang, Z., Jin, L., Qian, J., & Zheng, L. (2024) · PeerJ · doi:10.7717/peerj.18636 · Cited by 127
Trofe-Clark, J., Brennan, D. C., West-Thielke, P., Milone, M. C., Lim, M. A., Neubauer, R., Nigro, V., & Bloom, R. D. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2017.07.018 · Cited by 93
The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients
Campagne, O., Mager, D. E., Brazeau, D., Venuto, R. C., & Tornatore, K. M. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13811 · Cited by 31
Min, S., Papaz, T., Lambert, A. N., Allen, U., Birk, P., Blydt-Hansen, T., Foster, B. J., Grasemann, H., Hamiwka, L., Litalien, C., et al. (2022) · Transplantation · doi:10.1097/tp.0000000000003700 · Cited by 18
Impact of CYP3A5 genotype on de-novo LCP tacrolimus dosing and monitoring in kidney transplantation
Rao, N., Carcella, T., Patel, N., Bartlett, F., Posadas, M. A., Casey, M., Dubay, D. A., & Taber, D. J. (2023) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000494 · Cited by 5
Villapalos-García, G., Zubiaur, P., Marián-Revilla, C., Soria-Chacartegui, P., Navares-Gómez, M., Mejía-Abril, G., Rodríguez-Lopez, A., González-Iglesias, E., Martín-Vílchez, S., Román, M., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13111566 · Cited by 4
Metadata
- Authors
- Birdwell, K., Decker, B., Barbarino, J., Peterson, J., Stein, C., Sadee, W., Wang, D., Vinks, A., He, Y., Swen, J., Leeder, J., van Schaik, R., Thummel, K., Klein, T., Caudle, K., & MacPhee, I.
- Affiliations
- Division of Nephrology Department of Medicine Vanderbilt University Nashville Tennessee USA
- Division of Nephrology and Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA
- Department of Genetics Stanford University Stanford California USA
- Department of Medicine Vanderbilt University Nashville Tennessee USA
- Center for Pharmacogenomics School of Medicine, The Ohio State University Columbus Ohio USA
- Division of Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
- Institute of Clinical Pharmacology, Central South University Changsha Hunan Peoples Republic of China
- Department of Clinical Pharmacy and Toxicology Leiden University Medical Center Leiden The Netherlands
- Division of Clinical Pharmacology and Therapeutic Innovation, Department of Pediatrics Children's Mercy Hospitals and Clinics Kansas City Missouri USA
- Department of Clinical Chemistry Erasmus MC Rotterdam The Netherlands
- Department of Pharmaceutics University of Washington Seattle Washington USA
- Department of Pharmaceutical Sciences St. Jude Children's Research Hospital Memphis Tennessee USA
- Institute of Medical and Biomedical Education, Renal Medicine, St. George's, University of London London UK
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2015-06-03
- Volume
- 98
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0009-9236
- 1532-6535
- Cited by
- 730
- References
- 0
- Language
- en
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