Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients

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Calcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation

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Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus

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Tacrolimus oral bioavailability doubles with coadministration of ketoconazole*

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High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation

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A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients

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AN OPEN-LABEL, CONCENTRATION-RANGING TRIAL OF FK506 IN PRIMARY KIDNEY TRANSPLANTATION

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Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation

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Low systemic exposure to tacrolimus correlates with acute rejection

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Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure

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Therapeutic drug monitoring of tacrolimus with the dried blood spot method

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Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children

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One-Year Results with Extended-Release Tacrolimus/MMF, Tacrolimus/MMF and Cyclosporine/MMF in De Novo Kidney Transplant Recipients

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Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology

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Tacrolimus whole blood concentrations correlate closely to side‐effects in renal transplant recipients

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A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype‐Based With Body‐Weight‐Based Tacrolimus Dosing After Living Donor Kidney Transplantation

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AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients

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Dosing equation for tacrolimus using genetic variants and clinical factors

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Tacrolimus Once Daily (ADVAGRAF) Versus Twice Daily (PROGRAF) in De Novo Renal Transplantation: A Randomized Phase III Study

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Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation

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New Insights Into the Pharmacokinetics and Pharmacodynamics of the Calcineurin Inhibitors and Mycophenolic Acid: Possible Consequences for Therapeutic Drug Monitoring in Solid Organ Transplantation

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Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection After Renal Transplantation: A Pooled Analysis From Three Randomized-Controlled Clinical Trials

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Effect of a New FunctionalCYP3A4Polymorphism on Calcineurin Inhibitors‘ Dose Requirements and Trough Blood Levels in Stable Renal Transplant Patients

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Minimization of Immunosuppressive Therapy After Renal Transplantation: Results of a Randomized Controlled Trial

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Cyclosporine Withdrawal from a Mycophenolate Mofetil–Containing Immunosuppressive Regimen

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DOSE OPTIMIZATION OF MYCOPHENOLATE MOFETIL WHEN ADMINISTERED WITH A LOW DOSE OF TACROLIMUS IN CADAVERIC RENAL TRANSPLANT RECIPIENTS

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Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations

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Pharmacokinetics for Once- Versus Twice-Daily Tacrolimus Formulations in De Novo Kidney Transplantation: A Randomized, Open-Label Trial

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Monitoring Nonadherence and Acute Rejection With Variation in Blood Immunosuppressant Levels in Pediatric Renal Transplantation

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Efficacy, safety, and immunosuppressant adherence in stable liver transplant patients converted from a twice-daily tacrolimus-based regimen to once-daily tacrolimus extended-release formulation

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Switching ST udy of Kidney TRansplant PA tients with Tremor to LCP ‐TacrO ( STRATO ): an open‐label, multicenter, prospective phase 3b study

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In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Hematocrit Predict Tacrolimus Dose Requirements and Clearance in Renal Transplant Patients

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Factors affecting variability in distribution of tacrolimus in liver transplant recipients

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Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study

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Lower Variability of Tacrolimus Trough Concentration After Conversion From Prograf to Advagraf in Stable Kidney Transplant Recipients

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Non-Adherence and Graft Failure in Adult Liver Transplant Recipients

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Lower Variability in 24-Hour Exposure During Once-Daily Compared to Twice-Daily Tacrolimus Formulation in Kidney Transplantation

Stifft, F., Stolk, L. M., Undre, N. A., van Hooff, J. P., & Christiaans, M. H. L. (2013) · Transplantation · doi:10.1097/01.tp.0000437561.31212.0e · Cited by 111 · see citing works

Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study

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CYP3A5 and ABCB1 Polymorphisms Influence Tacrolimus Concentrations in Peripheral Blood Mononuclear Cells After Renal Transplantation

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Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone.

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Clinical Pharmacokinetics of Once-Daily Tacrolimus in Solid-Organ Transplant Patients

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Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet?

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Renal Allograft Dysfunction Associated with Rifampin–Tacrolimus Interaction

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Patterns of End-Stage Renal Disease Caused by Diabetes, Hypertension, and Glomerulonephritis in Live Kidney Donors

Anjum, S. K., Muzaale, A. D., Massie, A. B., Bae, S., Luo, X., Grams, M. E., Lentine, K. L., Garg, A. X., & Segev, D. L. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13917 · Cited by 96 · see citing works

A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach

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Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: a novel perspective toward individually optimized drug doses of cyclosporine A

Giese, T., Zeier, M. G., Schemmer, P., Uhl, W., Schoels, M., Dengler, T. J., Buechler, M. W., & Meuer, S. C. (2004) · Transplantation · doi:10.1097/01.tp.0000109260.00094.01 · Cited by 94 · see citing works

Pharmacodynamic analysis of tacrolimus and cyclosporine in living-donor liver transplant patients

Fukudo, M., Yano, I., Masuda, S., Fukatsu, S., KATSURA, T., Ogura, Y., Oike, F., TAKADA, Y., Tanaka, K., & Inui, K. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.04.008 · Cited by 89 · see citing works

Trough Tacrolimus Concentrations in the First Week After Kidney Transplantation Are Related to Acute Rejection

Borobia, A. M., Romero, I. R., Jiménez, C., Gil, F., Ramı́rez, E., de Gracia, R., Escuín, F., González, E., & Carcas, A. J. (2009) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e3181a8f02a · Cited by 83 · see citing works

A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation

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Genotype-guided tacrolimus dosing in African-American kidney transplant recipients

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Impact of Tacrolimus Intraindividual Variability and CYP3A5 Genetic Polymorphism on Acute Rejection in Kidney Transplantation

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Pharmacogenetic Biomarkers Predictive of the Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs

Picard, N., Bergan, S., Marquet, P., van Gelder, T., Wallemacq, P. E., Hesselink, D. A., & Haufroid, V. (2015) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000255 · Cited by 75 · see citing works

A Randomized Controlled Clinical Trial Comparing Belatacept With Tacrolimus After De Novo Kidney Transplantation

de Graav, G. N., Baan, C. C., Groningen, M. C. C., Kraaijeveld, R., Dieterich, M., Verschoor, W., von der Thüsen, J. H., Roelen, D. L., Cadogan, M., van de Wetering, J., et al. (2017) · Transplantation · doi:10.1097/tp.0000000000001755 · Cited by 71 · see citing works

Changes in Tacrolimus Distribution in Blood and Plasma Protein Binding Following Liver Transplantation

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Long-Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype

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Tacrolimus Inhibits NF-κB Activation in Peripheral Human T Cells

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The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function

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Impaired NF-kB Activation in T Cells Permits Tolerance to Primary Heart Allografts and to Secondary Donor Skin Grafts

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Pharmacodynamic Disparities in Tacrolimus-Treated Patients Developing Cytomegalus Virus Viremia

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Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation

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Therapeutic Drug Monitoring of Belatacept in Kidney Transplantation

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Meltdose Tacrolimus Pharmacokinetics

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A Transient Increase of Calcineurin Phosphatase Activity in Living-Donor Kidney Transplant Recipients with Acute Rejection

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SEX AND ETHNICITY MAY CHIEFLY INFLUENCE THE INTERACTION OF FLUCONAZOLE WITH CALCINEURIN INHIBITORS12

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Effect of Mild Diarrhea on Tacrolimus Exposure

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Pretransplant Tacrolimus Dose Requirements Predict Early Posttransplant Dose Requirements in Blood Group AB0-Incompatible Kidney Transplant Recipients

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Quantification of Torque Teno Virus Viremia as a Prospective Biomarker for Infectious Disease in Kidney Allograft Recipients

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Exploring the neuroregenerative potential of tacrolimus

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Immunosuppression-related neurological disorders in kidney transplantation

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Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism

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Individualized Dosage of Tacrolimus for Renal Transplantation Patients Based on Pharmacometabonomics

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Determining Plasma Tacrolimus Concentrations Using High-Performance LC-MS/MS in Renal Transplant Recipients

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INSIGHT INTO THE POTENTIAL INFLUENCE OF INTER- AND INTRA-INDIVIDUAL VARIABILITY OF TACROLIMUS EXPOSURE ON GRAFT FUNCTION DECLINE IN THREE-YEAR PERIOD FOLLOWING KIDNEY TRANSPLANTATION

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Therapeutic Drug Monitoring (TDM) and Toxicological Studies in Alternative Biological Matrices

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Renal Transplantation: Immunosuppression and Managing Allograft Rejection

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Tacrolimus’s Time Below Therapeutic Range Is Associated With Acute Pancreatic Graft Rejection and the Development of De Novo Donor-specific Antibodies

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Development and Validation of A Liquid Chromatography–Tandem Mass Spectrometry Method to Simultaneously Measure Tacrolimus and Everolimus Concentrations in Kidney Allograft Biopsies After Kidney Transplantation

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Conversion from Twice-Daily Prograf® to Once-Daily Advagraf® in Multi-ethnic Asian Adult Renal Transplant Recipients With or Without Concomitant Use of Diltiazem: Impact of CYP3A5 and MDR1 Genetic Polymorphisms on Tacrolimus Exposure

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Concentration-dependent blood binding: assessing implications through physiologically based Pharmacokinetic modeling of tacrolimus as a case example

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New-Onset Diabetes After Transplantation in Renal Recipients: A Pilot Comparative Study of Immediate vs. Extended-Release Tacrolimus Formulation

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Maintenance Immunosuppression in Solid Organ Transplantation: Integrating Novel Pharmacodynamic Biomarkers to Inform Calcineurin Inhibitor Dose Selection

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Exploring the Association Between Torquetenovirus Viral Load and Immunosuppressive Drug Exposure in Lung Transplantation

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Exploring Net Immunosuppressive Status with Torque Teno Virus Viral Load in Kidney Transplant Recipients with High Molecular Injury

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The Future of Paediatric Nephrology—Genomics and Personalised Precision Medicine

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Role of serum CXCL9 and CXCL13 in predicting infection after kidney transplant

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Progress in tacrolimus monitoring in organ transplantation : a multidisciplinary approach

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Dosing Tacrolimus Based on CYP3A5 Genotype: Will It Improve Clinical Outcome?

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Monitoring Intra-cellular Tacrolimus Concentrations in Solid Organ Transplantation: Use of Peripheral Blood Mononuclear Cells and Graft Biopsy Tissue

Sallustio, B. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.733285 · Cited by 25 · see citing works

Tacrolimus—why pharmacokinetics matter in the clinic

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Therapeutic drug monitoring of tacrolimus in kidney transplantation

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