Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Jones, HM, Chen, Y, Gibson, C, Heimbach, T, Parrott, N, Peters, SA, Snoeys, J, Upreti, VV +2 more·2015·Clinical Pharmacology & Therapeutics

DOI 10.1002/cpt.37

Cited by (487)

Items 201–300 of 487

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Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid
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Predicting drug-drug interactions with physiologically based pharmacokinetic/pharmacodynamic modelling and optimal dosing of apixaban and rivaroxaban with dronedarone co-administration
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Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor
Y. Amy Siu, Weidong G. Lai · 2016 · Drug Metabolism and Disposition
Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populations: An Example Using Tofacitinib
Susanna Y.H. Tse, Martin E. Dowty, Sujatha S. Menon, Pankaj Kumar Gupta, Sriram Krishnaswami · 2020 · The Journal of Clinical Pharmacology
A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors
Hinke Siebinga, Berlinda J. de Wit–van der Veen, Jos H. Beijnen, M. P. M. Stokkel, Thomas P. C. Dorlo, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx · 2021 · EJNMMI Research
Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition
Parsshava Mehta, Amira Soliman, Leyanis Rodríguez‐Vera, Stephan Schmidt, Paula Muniz, Mónica Rodríguez, Marta Forcadell, Emili Gonzalez-Perez, Valvanera Vozmediano · 2024 · Pharmaceutics
Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects
Yuki Matsumoto, Tamara D. Cabalu, Punam Sandhu, Georgy Hartmann, Takashi Iwasa, Hiroyuki Yoshitsugu, Christopher R. Gibson, Naoto Uemura · 2018 · Clinical Pharmacology & Therapeutics
Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations
Chaozhuang Shen, Wenxin Shao, Wenhui Wang, Hua Sun, Xiaohu Wang, Kuo Geng, Xingwen Wang, Haitang Xie · 2023 · CPT Pharmacometrics & Systems Pharmacology
A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models
Megerle L. Scherholz, James K. Forder, Ioannis P. Androulakis · 2018 · Journal of Pharmacokinetics and Pharmacodynamics
Development and evaluation of a harmonized whole body physiologically based pharmacokinetic (PBPK) model for flutamide in rats and its extrapolation to humans
Raju Prasad Sharma, Vikas Kumar, Marta Schuhmacher, Alexey N. Kolodkin, Hans Victor Westerhoff · 2019 · Environmental Research
Pharmacokinetics and population pharmacokinetics in pediatric oncology
Sebastiaan D. T. Sassen, Christian Michel Zwaan, Inge Margriet van der Sluis, Ron A. A. Mathôt · 2019 · Pediatric Blood & Cancer
In Vivo Predictive Dissolution Testing of Montelukast Sodium Formulations Administered with Drinks and Soft Foods to Infants
Joana Martir, Talia R. Flanagan, James Mann, Nikoletta Fotaki · 2020 · AAPS PharmSciTech
8‐acetoxy‐trisulfopyrene as the first activatable fluorogenic probe for add‐and‐read assessment of Organic anion‐transporting polypeptides, OATP1B1, OATP1B3, and OATP2B1
Orsolya Ungvári, Laura Király, Éva Bakos, Csilla Özvegy‐Laczka · 2021 · The FASEB Journal
A Physiologically Based Pharmacokinetic Model for Predicting Diazepam Pharmacokinetics after Intravenous, Oral, Intranasal, and Rectal Applications
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Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition
Eric D. Eisenmann, Qiang Fu, Elizabeth M. Muhowski, Yan Jin, Muhammad Erfan Uddin, Dominique A. Garrison, Robert H. Weber, Jennifer Ann Woyach, John C. Byrd, Alex Sparreboom et al. · 2021 · Cancer Research Communications
Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration–Time Profile at Infected Tissue
Zhongxia Tan, Youxi Zhang, Chao Wang, Le Sun · 2021 · Frontiers in Pharmacology
Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin
Jing Fan Yang, Xun Gong, Naveed A. Bakh, Kelley M. Carr, Nelson F. B. Phillips, Faramarz Ismail‐Beigi, Michael Aaron Weiss, Michael S. Strano · 2020 · Diabetes
Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
Ryan Takahashi, William F. Forrest, Alexander D. Smith, Justine Badée, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil John Parrott, Stephen M. Fowler · 2021 · Drug Metabolism and Disposition
Effect of a Ketohexokinase Inhibitor (PF‐06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug
David A. Tess, Emi Kimoto, Amanda King‐Ahmad, Manoli Vourvahis, A. David Rodrigues, Arthur J. Bergman, Ruolun Qui, Veena R. Somayaji, Yan Weng, Kari R. Fonseca et al. · 2022 · Clinical Pharmacology & Therapeutics
Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model
Takafumi Kato, Tsuyoshi Mikkaichi, Yasushi Yoshigae, Noriko Okudaira, Takako Shimizu, Takashi Izumi, Shuichi Ando, Yoshiaki Matsumoto · 2021 · International Journal of Pharmaceutics
The MPRINT Hub Data, Model, Knowledge and Research Coordination Center: Bridging the gap in maternal–pediatric therapeutics research through data integration and pharmacometrics
Sara K. Quinney, Robert R. Bies, Shaun J. Grannis, Christopher W. Bartlett, Eneida A. Mendonça, Colin M. Rogerson, Carl H. Backes, Dhaval K. Shah, Emma M. Tillman, Maged M. Costantine et al. · 2023 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach
James Harrison, Tom De Bruyn, Adam S. Darwich, James Brian. Houston · 2018 · Drug Metabolism and Disposition
Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
Andrea Treyer, Mohammed Ullah, Neil John Parrott, Birgit Molitor, Stephen M. Fowler, Per Artursson · 2019 · The AAPS Journal
Facing the challenges of multiscale modelling of bacterial and fungal pathogen–host interactions
Jana Schleicher, Theresia Conrad, Mika Gustafsson, Gunnar Cedersund, Reinhard Guthke, Jörg Linde · 2016 · Briefings in Functional Genomics
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations
Markus Krauß, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan‐Frederik Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert et al. · 2017 · npj Systems Biology and Applications
Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example
Barbara Wiśniowska, Sebastian Polak · 2016 · Journal of Pharmaceutical Sciences
Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools
Xu Zhou, Jiening Dun, Xiao Chen, Bai Xiang, Yunjie Dang, Deying Cao · 2022 · CPT Pharmacometrics & Systems Pharmacology
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research
Xinyi Wu, Jie En Valerie Sia, M. T. Vu Hai, Xuan Lai, Haiyan Li, Cheng Cui, Dongyang Liu · 2023 · Current Drug Metabolism
Abemaciclib pharmacology and interactions in the treatment of HR+/HER2− breast cancer: a critical review
Federica Martorana, Maria Vita Sanò, Maria Rosaria Valerio, Stefano Fogli, Paolo Giovanni Vigneri, Romano Danesi, Vittorio Gebbia · 2024 · Therapeutic Advances in Drug Safety
Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC–MS/MS
Chao Ma, Qiyan Lin, Ya-Fu Xue, Zhengcai Ju, Gang Deng, Wei Liu, Yuting Sun, Huida Guan, Xuemei M. Cheng, Changhong Wang · 2021 · Biomedical Chromatography
Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging
Christopher R. Gibson, Alexa Gleason, Eric J. Messina · 2021 · Pharmacology Research & Perspectives
Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights
Priyanka Arora, Gary A. Gudelsky, Pankaj B. Desai · 2021 · PLoS ONE
Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making
Nassim Djebli, Vincent Buchheit, Neil John Parrott, Elena Guerini, Yumi Cleary, Stephen M. Fowler, Nicolas Frey, Li J. Yu, François Mercier, Alex Phipps et al. · 2021 · European Journal of Drug Metabolism and Pharmacokinetics
Manipulation of Physiological Processes for Pharmaceutical Product Development
Rahul Maheshwari, Kaushik Kuche, Ankita Mane, Yashu Chourasiya, Muktika Tekade, Rakesh Kumar Tekade · 2018 · Elsevier eBooks
Assessment of OATP transporter‐mediated drug–drug interaction using physiologically‐based pharmacokinetic (PBPK) modeling – a case example
Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C. Chen, Edna F. Choo, Srikumar Sahasranaman, Lichuan Liu · 2018 · Biopharmaceutics & Drug Disposition
Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis
Véronique M P de Bruijn, Ivonne M.C.M. Rietjens, Hans Bouwmeester · 2022 · Archives of Toxicology
Saliva Sampling in Therapeutic Drug Monitoring and Physiologically Based Pharmacokinetic Modeling: Review
May Almukainzi · 2022 · Drug Research
Quantitative prediction of human pharmacokinetics and pharmacodynamics of imigliptin, a novel DPP-4 inhibitor, using allometric scaling, IVIVE and PK/PD modeling methods
Dongyang Liu, Xifeng Ma, Yang Liu, Huimin Zhou, Chongtie Shi, Frank Shao-Ying Wu, Ji Jiang, Pei Hu · 2016 · European Journal of Pharmaceutical Sciences
The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling
Amira M. Ghoneim, Suzan M. Mansour · 2020 · Drug Design Development and Therapy
Simplifying the Execution of HepatoPac MetID Experiments: Metabolite Profile and Intrinsic Clearance Comparisons
T. Eric Ballard, Nicole A. Kratochwil, Loretta M. Cox, Mark A. Moen, Florian Klammers, Aynur Ekiciler, Andreas Goetschi, Isabelle Walter · 2020 · Drug Metabolism and Disposition
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP
Lars Kuepfer, Georg Fuellen, Thomas Stahnke · 2023 · CPT Pharmacometrics & Systems Pharmacology
Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models
Makiko Yamada, Tomoko Ishizuka, Shin‐ichi Inoue, Veronika Rozehnal, Thomas Fischer, Daisuke Sugiyama · 2020 · Drug Metabolism and Disposition
Pharmacists in Australian general practice: an opportunity for expertise in precision medicine
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Physiologically based pharmacokinetic modeling and simulation to predict drug–drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia
Chandra Prakash, Bin Fan, Alice Ban Ke, Kha N. Le, Hua Yang · 2020 · Cancer Chemotherapy and Pharmacology
An overview of current alternative models in the context of ocular surface toxicity
Noémie Bonneau, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Françoise Brignole‐Baudouin · 2021 · Journal of Applied Toxicology
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Qiuyu Jia, Qingfeng He, Yao Li, Min Li, Jiaying Lin, Zhijia Tang, Xiao Zhu, Xiaoqiang Xiang · 2022 · Molecules
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Lu Gaohua, Mian Zhang, Caroline J. Sychterz, Ming Chang, Brian James Schmidt · 2023 · International Journal of Molecular Sciences
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Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou · 2025 · Clinical and Translational Science
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Quantitative aspects of drug permeation across in vitro and in vivo barriers
Stefanie D. Krämer · 2015 · European Journal of Pharmaceutical Sciences
Extrapolation of Elementary Rate Constants of P-glycoprotein–Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells
Zhou Meng, Harma M. Ellens, Joe Bentz · 2016 · Drug Metabolism and Disposition
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor
Nicole A. Kratochwil, Miriam Triyatni, Martina B. Mueller, Florian Klammers, Brian Leonard, Dan Turley, Josephine Schmaler, Aynur Ekiciler, Birgit Molitor, Isabelle Walter et al. · 2018 · Journal of Pharmacology and Experimental Therapeutics
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Rauf-ur-Rehman, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Talha Saleem, Faaiza Qazi, Momina Zarish Khan, Asma Irshad, Lubna Bashir et al. · 2023 · Frontiers in Pharmacology
Enterohepatic Circulation Effect in Physiologically Based Pharmacokinetic Models: The Sorafenib Case
Roberto Andrea Abbiati, Davide Manca · 2017 · Industrial & Engineering Chemistry Research
Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
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European Regulatory Perspective on Pediatric Physiologically Based Pharmacokinetic Models
Susan M. Cole, Justin L. Hay, Elisa Luzon, Anna Nordmark, Ine Skottheim Rusten · 2017 · International Journal of Pharmacokinetics
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Modeling of the Nanoparticles Absorption Under a Gastrointestinal Simulated Ambient Condition
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Identification of solubility-limited absorption of oral anticancer drugs using PBPK modeling based on rat PK and its relevance to human
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Biliary Excretion–Mediated Food Effects and Prediction
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PBPK Analysis to Study the Impact of Genetic Polymorphism of NAT2 on Drug-Drug Interaction Potential of Isoniazid
Ankit Balhara, Saranjit Singh · 2021 · Pharmaceutical Research
Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex
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Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
Kenta J. Yoshida, Kazuya Maeda, Akihiko Konagaya, Hiroyuki Kusuhara · 2018 · Drug Metabolism and Disposition
Pharmacokinetics of Coencapsulated Antiretrovirals with Ingestible Sensors
Honghu Liu, Eric S. Daar, Yan Wang, Lisa Siqueiros, Kayla M. Campbell, Jie Shen, Mario Guerrero, Meng-Wei Ko, Di Xiong, John Dao et al. · 2019 · AIDS Research and Human Retroviruses
Stochastic modeling of human papillomavirusearly promoter gene regulation
Alberto Giaretta, GIANNA MARIA TOFFOLO, Timothy C. Elston · 2019 · Journal of Theoretical Biology
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PBPK Modeling of Slightly Soluble Silver Nanomaterials and Regulatory Acceptance
Frederick C. Klaessig · 2020 · Small
Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method
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Assessing interindividual variability by Bayesian-PBPK modeling
Markus Krauß, Andreas Schuppert · 2016 · Drug Discovery Today Disease Models
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J. Gerry Kenna, John C. Waterton, Andreas R. Baudy, Aleksandra Galetin, Catherine D. G. Hines, Paul D. Hockings, Manishkumar R. Patel, Daniel Scotcher, Steven P. Sourbron, Sabina Ziemian et al. · 2018 · Methods in pharmacology and toxicology
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Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach
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Mo’tasem M. Alsmadi, Nour Aldaoud, Rana Obaidat, Niazy Abu Farsakh · 2022 · AAPS PharmSciTech
Physiologically Based Pharmacokinetic (PBPK) Modelling
Ankit Balhara, Sumeet Kale, Saranjit Singh · 2022 · Springer eBooks
ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application
He-Qun Li, Fazila Bunglawala, N. Hewitt, R. Pendlington, R. Cubberley, B. Nicol, S. Spriggs, M. Baltazar, S. Cable, M. Dent · 2023 · Toxicological Sciences
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Pharmacodynamic Drug–Drug Interactions
Ming Zheng · 2018 · Springer eBooks
Assessment and Confirmation of Species Difference in Nonlinear Pharmacokinetics of Atipamezole with Physiologically Based Pharmacokinetic Modeling
Zheng Li, You Gao, Chunmiao Yang, Yanan Xiang, Wenpeng Zhang, Tianhong Zhang, Ruibin Su, Chuang Lu, Xiaomei Zhuang · 2019 · Drug Metabolism and Disposition
Role of transporters in drug disposition and drug-drug interactions
Xiaomin Liang, Kelly MacLennan Staiger, Ellen Riddle, Hao Jia, Yurong Lai · 2020 · Elsevier eBooks
Quantitation of Plasma Membrane Drug Transporters in Kidney Tissue and Cell Lines Using a Novel Proteomic Approach Enabled a Prospective Prediction of Metformin Disposition
Ryota Kikuchi, William J.H. Chiou, Kenneth R. Durbin, John P. Savaryn, Junli Ma, Arian Emami Riedmaier, Sonia M. de Morais, Gary J. Jenkins, Daniel A.J. Bow · 2021 · Drug Metabolism and Disposition
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Evolution of human pharmacokinetics prediction methods: from allometry to artificial intelligence
Nayoung Choi, Beom Soo Shin, Soyoung Shin · 2026 · Journal of Pharmaceutical Investigation
Pharmacokinetic and metabolism study of ginsenoside Rb2 in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry
Wan Wang, Li Ha, Xinyuan Li, Zheng Wei-wan, Encheng Yang · 2021 · Biomedical Chromatography