Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Jones, HM, Chen, Y, Gibson, C, Heimbach, T, Parrott, N, Peters, SA, Snoeys, J, Upreti, VV +2 more·2015·Clinical Pharmacology & Therapeutics

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  3. Drug–Drug Interactions: Computational Approaches
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  4. Views on the Therapeutic Needs of Older Adults
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  5. Human PK Prediction and Modeling
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  6. Role of Systems Modeling in Regulatory Drug Approval
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  7. Stereoselective biosynthesis of 3′-azido-3′-deoxythymidine 5′-O-β-D-ribopyranoside and in vitro evaluation as potential antileishmanial with in silicoADME prediction
    Evilanna Lima Arruda, Elaine Sousa Nunes, Kamila Bohne Japiassu, Paula Letícia de Melo Souza, Kelly Carolina Frauzino Araújo Cordeiro, Marina Clare Vinaud, Valéria de Oliveira · 2019 · Process Biochemistry
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  10. Confidence Assessment of an Absorption Model Using Limited Solubility and Permeability Data for 21 Drugs within a Dynamic Physiologically-Based Pharmacokinetic Simulator
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  11. Application and Impact of Human Dose Projection from Discovery to Early Drug Development
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  12. Applications of Pediatric PBPK Modeling: Current Status for Drug Development Processes and Use in Clinical Settings
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  13. Translational Medicine: Enabling the Proof of Concepts
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  14. Prediction of Human Pharmacokinetics and Pharmacodynamics
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  15. APPLICATION OF PHYSIOLOGICALLY BASED PHARMACOKINETIC AND PHARMACODYNAMIC (PBPK/PD) MODELING COMPRISING TRANSPORTERS
    Matthew D. Harwood, Amin Rostami‐Hodjegan, Sibylle Neuhoff · 2022 · Wiley eBooks
  16. Research and development of nanosized drug containing nasal drug delivery systems to reach systemic and central nerve system effect
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  17. Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects
    Fabio Broccatelli, Vijayabhaskar Veeravalli, Daniel K. Cashion, Javier L. Baylon, Franco Lombardo, Lei Jia · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic
    Bianca M. Liederer, Xingrong Liu, Simon G.W. Wong, Daniel R. Mudra · 2017 · AAPS advances in the pharmaceutical sciences series
  19. EFFECT OF ETHANOL ON GASTROINTESTINAL TIGHT JUNCTIONS AND P-GLYCOPROTEIN EXPRESSION AND FUNCTIONALITY
    Armin Sadighi · 2018
  20. Application Of Quantitative Pharmacological Modeling To Improve Drug Therapy In Older Adults
    Chay Ngee Lim · 2016 · University of Minnesota Digital Conservancy (University of Minnesota)
  21. Mechanistic Physiologically based Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Models to Evaluate the Mutual Relationships between an Acid Pump Antagonist and Intragastric pH in Humans
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  22. Physiologically based pharmacokinetic models to support modernized chemical safety assessment
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  23. Assessment of Exposures in Vulnerable Populations: Exposure and Response Modelling for Environmental Contaminants Through a Lifetime
    Jennifer Ann Lowry · 2019 · Encyclopedia of the UN sustainable development goals
  24. The role of quantitative modeling and simulation in translational science
    Venkatesh Pilla Reddy, Andy Zhu · 2020 · Elsevier eBooks
  25. Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling
    Byeong ill Lee, Jeong-Hyeon Lim, Min‐Ho Park, Seok‐Ho Shin, Jin‐Ju Byeon, Jangmi Choi, Seojin Park, Min-Jae Park, Yuri Park, Young Geun Shin · 2020 · Translational and Clinical Pharmacology
  26. Application Of A Physiologically-Based Pharmacokinetic (PBPK) Model In Predicting Drug Interactions
    Maya P. Radeva-Ilieva, Kaloyan Georgiev · 2020 · Annual for Hospital Pharmacy
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    Megerle L. Scherholz · 2019
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    Miguel David Betancourt López, Nicolás Calderón González · 2013 · Digital Library (University of San Buenaventura Colombia)
  30. Biopharmaceutics to Inform Candidate Drug Selection and Optimisation
    Linette Ruston · 2021
  31. EPILOGUE
    Sheila Annie Peters · 2021
  32. PBPK MODELING AND SIMULATIONS TO EVALUATE CLINICAL DRUG‐DRUG INTERACTIONS
    Sheila Annie Peters · 2021
  33. NONCLINICAL, CLINICAL, AND MODEL‐INFORMED DRUG DEVELOPMENT
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    Sheila Annie Peters · 2021
  35. Regional Intestinal Drug Absorption
    Maria Isabel Gonzalez-Alvarez, Arik Dahan · 2022 · MDPI eBooks
  36. Physiologically Based Pharmacokinetic (PBPK) Modeling: Applications in Drug Development
    Manuel Ibarra, Alejandra Schiavo, Lawrence J. Lesko · 2021 · Springer eBooks
  37. Assessment of Exposures in Vulnerable Populations: Exposure and Response Modelling for Environmental Contaminants Through a Lifetime
    Jennifer Ann Lowry · 2019 · Encyclopedia of the UN sustainable development goals
  38. Physiologically Based Pharmacokinetic (PBPK) Modeling: Model Development and Evaluation
    Manuel Ibarra, Alejandra Schiavo, Lawrence J. Lesko · 2021 · Springer eBooks
  39. Physiologically Based Pharmacokinetic (PBPK) Modeling: Applications in Drug Development
    Manuel Ibarra, Alejandra Schiavo, Lawrence J. Lesko · 2022 · Springer eBooks
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    Caroline Rynn, Arthur J. Van De Vyver, Antje‐Christine Walz, Carina Cantrill, Matthias Wittwer · 2022
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    Ioannis Loisios-Konstantinidis · 2022
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    Huali Lan · 2023 · Applied Mathematics and Nonlinear Sciences
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    Arian Emami Riedmaier · 2023 · Elsevier eBooks
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    Hinke Siebinga · 2023
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    Fabio Broccatelli, Radha Ramakrishnan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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    Emile P. Chen · 2025
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    Saba Khan, Aditi Pandey, Somesh Mishra, Roja Rani Budha, GSN Koteswara Rao · 2025 · Springer eBooks
  52. Advancing Pediatric Drug Safety: The Potential of Physiologically Based Pharmacokinetic Modeling
    Krishna Yadav · 2025 · Drug Metabolism and Bioanalysis Letters
  53. High-resolution fecal pharmacokinetic modeling in mice with orally administered antibiotics
    Rie Maskawa, Lena Takayasu, Hideki Takayasu C, Keiji Watanabe, Shusuke Takemine, Takashi Kakimoto, Kozue Takeshita, Seiko Narushima, Wataru Suda, Misako Takayasu · 2025 · Scientific Reports
  54. Revisiting the Role of Plasma-to-Blood Partitioning in Pharmacokinetics
    Amarinder Singh, Bernd Meibohm · 2025 · European Journal of Drug Metabolism and Pharmacokinetics
  55. Development of PBPK Population Model for End-Stage Renal Disease Patients to Inform OATP1B-, BCRP-, P-gp-, and CYP3A4-Mediated Drug Disposition with Individual Influencing Factors
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    Hua He, Jinwei Zhu, Jiahao Chen, Huijie Guo, Simiao Yu, Huihui Hu, Xiaodan Hong, Hui Yu, Ting Wang, Guangji Wang et al. · 2026 · Drug Metabolism and Disposition
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    T. Megala, P. Aurchana, R. VasanthSelvakumar, Malathy Shanmugam · 2026 · International Conference on Intelligent Data Communication Technologies and Internet of Things (IDCIoT)
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