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Acute adverse reactions to prednisone in relation to dosage
Abstract
Among 718 consecutively monitored hospitalized medical patients who received prednisone, adverse reactions were recorded in 121 (16.9 per cent). Of these, 82 experienced acute reactions (11.4 per cent of the total series), and 39 (5.4 per cent) had a more gradual onset of the reactions. The daily dose of prednisone was analyzed in 594 patients in whom adverse reactions were not recorded and in the 82 patients with acute reactions. While there was a striking dose‐response relationship for acute psychiatric reactions, there was no correlation between dose and gastrointestinal side effects, diabetes, superinfections, and leukocytosis.
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Cited by
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586
Steroid-induced psychiatric syndromes
Lewis, D. A., & Smith, R. E. (1983) · Journal of Affective Disorders · doi:10.1016/0165-0327(83)90022-8 · Cited by 528
Fardet, L., Petersen, I., & Nazareth, I. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11071009 · Cited by 287
Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158
Metadata
- Authors
- Program, T. B. C. D. S.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1972-09
- Volume
- 13
- Issue
- 5part1
- Pages
- 694-698
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W4254755517
- Cited by
- 335
- References
- 0
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
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