Cited by 672Stress Responses and CortisolTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

Plotsky, Paul M., Owens, Michael J., Nemeroff, Charles B.·1998·Psychiatric Clinics of North America

Abstract

Among the more consistent observations in patients with major depression is dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis presenting as elevation of basal cortisol, dexamethasone-mediated negative feedback resistance, increased cerebrospinal fluid levels of corticotropin-releasing factor (CRF), and a blunted adrenocorticotropic hormone (ACTH) response to challenge with exogenous CRF. These features appear to be state, rather than trait markers, and are normalized upon successful treatment. These pathophysiologic adaptations may arise from defects in central drive to the neuroendocrine hypothalamus, disruption of normal adrenocortical hormone receptor function or a modification of HPA axis function at any level. Functional assessment of the HPA axis is thought to provide a window into central nervous system operation that may be of diagnostic value in this and other affective disorders regardless of whether CRF and glucocorticoids are directly involved in the origin of major depression or merely exacerbate the consequences of other primary defects.

Integrity signals

Registry

Crossref · 10.1016/s0193-953x(05)70006-x

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B.
Affiliations
Emory University (US)
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
1998-06
Volume
21
Issue
2
Pages
293-307
ISSN
0193-953X (ISSN-L)
OpenAlex
W3240440
Cited by
672
References
144
Citations by year
2026: 6 · 2025: 5 · 2024: 14 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 22 · 2018: 18 · 2017: 11 · 2016: 16 · 2015: 19 · 2014: 26 · 2013: 28 · 2012: 35
FWCI
10.42
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
major depressive disorder, psychoneuroendocrinology, diathesis-stress model, genetic susceptibility, epigenetic factors, life events, neuroplasticity, developmental neuroscience, psychoanalytic theory, anxiety disorders, perinatal period, peripubertal period
MeSH terms
Depression, Female, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Receptors, Glucocorticoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review