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Minimization: A new method of assigning patients to treatment and control groups
Abstract
This paper describes a new method of assigning patients to treatment and control groups to minimize differences between the groups, not only in the number of patients but in patient characteristics. Testing the method by computer simulations, using data on 40 patients with 15 variates each, demonstrates a four‐ to fivefold reduction of the probability of severe imbalance, relative to randomization. Minimization can maintain tight control of one variate, comparable to the currently acceptable experimental design of blocking, while reduCing the probability of severe imbalance in the other 14 variates by a factor of 3. It also compares favorably with accepted methods regarding susceptibility to experimenter bias. Therefore, it is suggested that minimization should replace randomization in assigning patients in clinical trials.
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Gianni, L., Eiermann, W., Semiglazov, V., Manikhas, A., Lluch, A., Tjulandin, S., Zambetti, M., Vazquez, F., Byakhow, M., Lichinitser, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61964-4 · Cited by 1,255
Effects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890
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The method of minimization for allocation to clinical trials
Scott, N. W., McPherson, G. C., Ramsay, C. R., & Campbell, M. K. (2002) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00242-8 · Cited by 651
Metadata
- Authors
- Taves, D. R.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1974-05
- Volume
- 15
- Issue
- 5
- Pages
- 443-453
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2467022164
- Cited by
- 891
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taves, D. R. (1974). Minimization: A new method of assigning patients to treatment and control groups. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt1974155443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
