Effects of Testosterone Treatment in Older Men
Open accessAbstract
BACKGROUND: Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established. METHODS: We assigned 790 men 65 years of age or older with a serum testosterone concentration of less than 275 ng per deciliter and symptoms suggesting hypoandrogenism to receive either testosterone gel or placebo gel for 1 year. Each man participated in one or more of three trials--the Sexual Function Trial, the Physical Function Trial, and the Vitality Trial. The primary outcome of each of the individual trials was also evaluated in all participants. RESULTS: Testosterone treatment increased serum testosterone levels to the mid-normal range for men 19 to 40 years of age. The increase in testosterone levels was associated with significantly increased sexual activity, as assessed by the Psychosexual Daily Questionnaire (P<0.001), as well as significantly increased sexual desire and erectile function. The percentage of men who had an increase of at least 50 m in the 6-minute walking distance did not differ significantly between the two study groups in the Physical Function Trial but did differ significantly when men in all three trials were included (20.5% of men who received testosterone vs. 12.6% of men who received placebo, P=0.003). Testosterone had no significant benefit with respect to vitality, as assessed by the Functional Assessment of Chronic Illness Therapy-Fatigue scale, but men who received testosterone reported slightly better mood and lower severity of depressive symptoms than those who received placebo. The rates of adverse events were similar in the two groups. CONCLUSIONS: In symptomatic men 65 years of age or older, raising testosterone concentrations for 1 year from moderately low to the mid-normal range for men 19 to 40 years of age had a moderate benefit with respect to sexual function and some benefit with respect to mood and depressive symptoms but no benefit with respect to vitality or walking distance. The number of participants was too few to draw conclusions about the risks of testosterone treatment. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT00799617.).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is accumulating evidence against a link between testosterone therapy and prostate cancer development.
“there is accumulating evidence against a link between testosterone therapy and prostate cancer development.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [24]
The Discussion reports four prostate cancer cases, three in men receiving testosterone, and explicitly says the sample was too small to assess the effect on prostate cancer risk reliably. The Conclusions likewise say there were too few participants to draw conclusions about treatment risks. The paper therefore does not present its findings as evidence against a link. (LLM, conf=0.86)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the Testosterone Trials, testosterone treatment improved 6-minute walk test results versus placebo (20.5% versus 12.6%; P=0.003).
“In the ‘Testosterone Trials’, treatment with testosterone improved participants’ results in the 6 min walk test compared with placebo (20.5% versus 12.6%; P = 0.003)53.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [53]
The Results > Efficacy section reports improved 6-minute walking outcomes with testosterone versus placebo among participants across all three Testosterone Trials, including P = 0.003 for the proportion whose walking distance increased by at least 50 m. Our copy does not give the cited 20.5% versus 12.6% figures. It also reports no significant difference for that outcome among participants in the Physical Function Trial alone. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRandomized controlled trials have shown no significant increase in the rate of prostate cancer diagnosis in older, testosterone deficient men treated with testosterone compared to placebo.
“Randomized controlled trials have shown that there is not a significant increase in the rate of a prostate cancer diagnosis in older, testosterone deficient men who were treated with testosterone compared to placebo.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [24]
The Results (Adverse Events; page not available) report one prostate cancer diagnosis during treatment in the testosterone group, followed by two in that group and one in the placebo group during the subsequent year. The Discussion says the sample was too small to assess reliably whether testosterone affects prostate cancer risk. The paper therefore supports that few diagnoses occurred, but not the stronger claim that the trials established no significant increase in the diagnosis rate. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn trials, patients with low testosterone have demonstrated statistically significant improvements in erectile function, sex drive, anemia, bone mineral density, lean body mass, and depressive symptoms.
“In trials, patients with low testosterone have demonstrated statistically significant improvements in erectile function, 24 sex drive, 24 anemia, 25 bone mineral density, 26 lean body mass, 27 and depressive symptoms. 24”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [24]
Testosterone supplementation benefits other aspects of health, including sexual function, physical function, vitality, quality of life and improved mood.
“Testosterone supplementation is also shown to benefit other aspects of health, including sexual function, physical function, vitality, quality of life and improved mood [109, 111].”
From Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review (2019) · cites this paper as [111]
Improvements in muscle and lean mass may not directly result in improved muscle function.
“Of note, potential improvements in muscle (and lean) mass may not directly result in improved muscle function214,215.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [214]
In the large T Trials, sexual function improved modestly with testosterone treatment.
“In the large T Trials, sexual function improved modestly with testosterone treatment,”
From Hypogonadism and male obesity: Focus on unresolved questions (2018) · cites this paper as [37]
Even older men with a relatively high comorbid burden (37% had diabetes and 15% a previous myocardial infarction) can respond to testosterone.
“suggesting that even older men with a relatively high comorbid burden (37% had diabetes and 15% a previous myocardial infarction) can respond to testosterone.37”
From Hypogonadism and male obesity: Focus on unresolved questions (2018) · cites this paper as [37]
In the Testosterone Trials of stringently selected symptomatic men with a baseline testosterone averaging <9.5 nmol/L for no apparent reason other than age, testosterone treatment had a modest benefit in sexual function, and some benefit with respect to mood and depressive symptoms.
“In the Testosterone Trials of stringently selected symptomatic men with a baseline testosterone averaging < 9.5 nmol/L (275 ng/dL) for no apparent reason other than age, testosterone treatment had a modest benefit in sexual function, and some benefit with respect to mood and depressive symptoms (15).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
In an intensive lifestyle RCT of relatively healthy obese middle-aged men, 15% weight loss increased the mean IIEF score by 3.10, which is clinically meaningful and similar to the increase of 2.64 reported in the Testosterone Trials.
“In an intensive lifestyle randomized controlled trial (RCT) of relatively healthy obese middle-aged men, 15% weight loss increased the mean International Index of Erectile Function (IIEF) score by 3.10, which is clinically meaningful (23) and similar to the increase of 2.64 reported in the Testosterone Trials, although those men were older (15).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
Although head-to-head studies are lacking, the efficacy reported for PDE5 inhibitors is greater than that reported for lifestyle intervention and testosterone treatment.
“Although head-to-head studies are lacking, the efficacy reported for PDE5 inhibitors is greater than that reported for lifestyle intervention and testosterone treatment (15, 25).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
In RCTs of middle-aged and older men, where contraindications were rigorously excluded and treatment carefully monitored, short-term testosterone treatment is associated with a low risk of adverse events.
“In RCTs of middle-aged and older men, where contraindications have been rigorously excluded and treatment was carefully monitored, short-term testosterone treatment has been associated with a low risk of adverse events (15).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
The Testosterone Trials was too small to reliably assess testosterone treatment-associated risks.
“Although the trial was too small to reliably assess testosterone treatment-associated risks (15)”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
The Testosterone Trials provides some assurance about the potential relative short-term safety of testosterone treatment in men without the previously mentioned contraindications.
“it does provide some assurance about the potential relative short-term safety of testosterone treatment in men without the previously mentioned contraindications.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
The Endocrine Society guideline recommendations are consistent with the exclusion criteria specified in the Testosterone Trials.
“These guideline recommendations are consistent with the exclusion criteria specified in the Testosterone Trials (15).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
In the 12-month Testosterone Trials, the rates of adverse events were similar in testosterone- and placebo-treated men.
“In the 12-month Testosterone Trials, the rates of adverse events were similar in the testosterone- and placebo-treated men.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
SF-36 health survey: Manual and interpretation guide
Ware, J. (2003) · Medical Entomology and Zoology · Cited by 11,424 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715 · see citing works
Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350 · see citing works
Two-stage residual inclusion estimation: Addressing endogeneity in health econometric modeling
Terza, J. V., Basu, A., & Rathouz, P. J. (2008) · Journal of Health Economics · doi:10.1016/j.jhealeco.2007.09.009 · Cited by 1,728 · see citing works
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494 · see citing works
Self-citationThe International Index of Erectile Function (IIEF): a state-of-the-science review
Rosen, R., Cappelleri, J. C., & Gendrano, N. (2002) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900857 · Cited by 1,045 · see citing works
Self-citationRedelmeier, D. A., Bayoumi, A. M., Goldstein, R. S., & Guyatt, G. H. (1997) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.155.4.9105067 · Cited by 1,029 · see citing works
Pattern-Mixture Models for Multivariate Incomplete Data
Little, R. J. A. (1993) · Journal of the American Statistical Association · doi:10.1080/01621459.1993.10594302 · Cited by 1,026 · see citing works
Vigen, R. (2013) · JAMA · doi:10.1001/jama.2013.280386 · Cited by 1,003 · see citing works
Assessing Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial
Thompson, I. M., Ankerst, D. P., Chen, C., Goodman, P. J., Tangen, C. M., Lucia, M. S., Feng, Z., Parnes, H. L., & Coltman, C. A. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj131 · Cited by 941 · see citing works
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939 · see citing works
Minimization: A new method of assigning patients to treatment and control groups
Taves, D. R. (1974) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1974155443 · Cited by 891 · see citing works
Cella, D. F., Eton, D. T., Lai, J., Peterman, A. H., & Merkel, D. E. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00529-8 · Cited by 808 · see citing works
Self-citationIncreased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., Fraumeni, J. F., & Hoover, R. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085805 · Cited by 735 · see citing works
Srinivas-Shankar, U., Roberts, S. A., Connolly, M. J., O'Connell, M. D. L., Adams, J. E., Oldham, J. A., & Wu, F. C. W. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1251 · Cited by 629 · see citing works
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1933 · Cited by 566 · see citing works
Self-citationXu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 562 · see citing works
Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2647 · Cited by 531 · see citing works
Self-citationBhasin, S., Pencina, M., Jasuja, G. K., Travison, T. G., Coviello, A., Orwoll, E., Wang, P. Y., Nielson, C., Wu, F., Tajar, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-3012 · Cited by 355 · see citing works
Self-citationSharma, R., Oni, O. A., Gupta, K., Chen, G., Sharma, M., Dawn, B., Sharma, R., Parashara, D., Savin, V. J., Ambrose, J. A., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv346 · Cited by 302 · see citing works
Corona, G., Maseroli, E., Rastrelli, G., Isidori, A. M., Sforza, A., Mannucci, E., & Maggi, M. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.950653 · Cited by 297 · see citing works
An Approximate Generalized Linear Model with Random Effects for Informative Missing Data
Follmann, D. A., & Wu, M. C. (1995) · Biometrics · doi:10.2307/2533322 · Cited by 293 · see citing works
The derogatis interview for sexual functioning (DISF/DISF-SR): An introductory report
Derogatis, L. R. (1997) · Journal of Sex & Marital Therapy · doi:10.1080/00926239708403933 · Cited by 287 · see citing works
Institute of Medicine (2004) · National Academies Press eBooks · doi:10.17226/10852 · Cited by 231 · see citing works
High-Sensitivity Tandem Mass Spectrometry Assay for Serum Estrone and Estradiol
Kushnir, M. M., Rockwood, A. L., Bergquist, J., Varshavsky, M., Roberts, W. L., Yue, B., Bunker, A. M., & Meikle, A. W. (2008) · American Journal of Clinical Pathology · doi:10.1309/lc03bhq5xjpjyekg · Cited by 209 · see citing works
Gray, P. B., Singh, A. B., Woodhouse, L. J., Storer, T. W., Casaburi, R. H., Dzekov, J., Dzekov, C., Sinha‐Hikim, I., & Bhasin, S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0247 · Cited by 203 · see citing works
Self-citationTravison, T. G., Basaria, S., Storer, T. W., Jette, A. M., Miciek, R., Farwell, W. R., Choong, K., Lakshman, K., Mazer, N. A., Coviello, A. D., et al. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr100 · Cited by 160 · see citing works
Self-citationVesper, H. W., Bhasin, S., Wang, C., Tai, S. S., Dodge, L. A., Singh, R. J., Nelson, J., Ohorodnik, S., Clarke, N. J., Salameh, W. A., et al. (2009) · Steroids · doi:10.1016/j.steroids.2009.01.004 · Cited by 152 · see citing works
Self-citationBhasin, S., Jasjua, G. K., Pencina, M. J., D’Agostino, R. B., Coviello, A. D., Vasan, R. S., & Travison, T. G. (2011) · Diabetes Care · doi:10.2337/dc11-0888 · Cited by 120 · see citing works
Self-citationThe Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men
Snyder, P. J., Ellenberg, S. S., Cunningham, G. R., Matsumoto, A. M., Bhasin, S., Barrett-Connor, E. L., Gill, T. M., Farrar, J. T., Cella, D. F., Rosen, R. C., et al. (2014) · Clinical Trials · doi:10.1177/1740774514524032 · Cited by 114 · see citing works
Self-citationVaughan, C. P., Goldstein, F. C., & Tenover, J. L. (2007) · Journal of Andrology · doi:10.2164/jandrol.107.002931 · Cited by 101 · see citing works
A Simple Self‐Report Diary for Assessing Psychosexual Function in Hypogonadal Men
Lee, K. K., Berman, N., Alexander, G. M., Hull, L., Swerdloff, R. S., & Wang, C. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02728.x · Cited by 63 · see citing works
Self-citationTestosterone and aging clinical research directions
Liverman, C. T., Blazer, D. G., & National Research Council (U.S.) (2004) · Cited by 36 · see citing works
Analysis of the efficacy and safety of sildenafil citrate in the geriatric population
Müller, A., Smith, L. J., Parker, M., & Mulhall, J. P. (2007) · British Journal of Urology · doi:10.1111/j.1464-410x.2007.06915.x · Cited by 30 · see citing works
Recruitment and Screening for the Testosterone Trials
Cauley, J. A., Fluharty, L., Ellenberg, S. S., Gill, T. M., Ensrud, K. E., Barrett-Connor, E. L., Cifelli, D., Cunningham, G. R., Matsumoto, A. M., Bhasin, S., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv031 · Cited by 30 · see citing works
Self-citation
Flagged first, then by citations
2 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00229 · Cited by 1,736 · see citing works
Self-citationBreast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A. E., ELIAS, A. D., Farrar, W. B., Forero, A., Giordano, S. H., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0012 · Cited by 1,607 · see citing works
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130 · see citing works
Self-citationCardiovascular Risks Associated with Gender and Aging
Rodgers, J. L., Jones, J., Bolleddu, S. I., Vanthenapalli, S., Rodgers, L. E., Shah, K., Karia, K., & Panguluri, S. K. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6020019 · Cited by 1,081 · see citing works
Welcome to the ICD‐10 code for sarcopenia
Anker, S. D., Morley, J. E., & von Haehling, S. (2016) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12147 · Cited by 983 · see citing works
Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., & Samuels, M. H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2118 · Cited by 945 · see citing works
Evaluation and Management of Testosterone Deficiency: AUA Guideline
Mulhall, J. P., Trost, L. W., Brannigan, R. E., Kurtz, E. G., Redmon, J. B., Chiles, K. A., Lightner, D. J., Miner, M. M., Murad, M. H., Nelson, C. J., et al. (2018) · Journal of Urology · doi:10.1016/j.juro.2018.03.115 · Cited by 766 · see citing works
Cardiovascular Safety of Testosterone-Replacement Therapy
Lincoff, A. M., Bhasin, S., Flevaris, P., Mitchell, L. M., Basaria, S. S., Boden, W. E., Cunningham, G. R., Granger, C. B., Khera, M., Thompson, I. M., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2215025 · Cited by 504 · see citing works
Self-citationCao, L., & Morley, J. E. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.001 · Cited by 424 · see citing works
Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone
Budoff, M. J., Ellenberg, S. S., Lewis, C. E., Mohler, E. R., Wenger, N. K., Bhasin, S., Barrett-Connor, E., Swerdloff, R. S., Stephens-Shields, A., Cauley, J. A., et al. (2017) · JAMA · doi:10.1001/jama.2016.21043 · Cited by 376 · see citing works
Self-citationThe physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349 · see citing works
Wittert, G., Bracken, K., Robledo, K. P., Grossmann, M., Yeap, B. B., Handelsman, D. J., Stuckey, B., Conway, A., Inder, W., McLachlan, R., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30367-3 · Cited by 362 · see citing works
Snyder, P. J., Kopperdahl, D. L., Stephens-Shields, A. J., Ellenberg, S. S., Cauley, J. A., Ensrud, K. E., Lewis, C. E., Barrett-Connor, E., Schwartz, A. V., Lee, D. C., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9539 · Cited by 363 · see citing works
Self-citationSarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355 · see citing works
Sarcopenia and cognitive impairment: A systematic review and meta-analysis
Peng, T., Chen, W., Wu, L.-W., Chang, Y., & Kao, T. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.12.014 · Cited by 334 · see citing works
Travison, T. G., Vesper, H. W., Orwoll, E., Wu, F., Kaufman, J. M., Wang, Y., Lapauw, B., Fiers, T., Matsumoto, A. M., & Bhasin, S. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2935 · Cited by 326 · see citing works
Self-citationPaediatric and adult-onset male hypogonadism
Salonia, A., Rastrelli, G., Hackett, G., Seminara, S. B., Huhtaniemi, I. T., Rey, R. A., Hellstrom, W. J. G., Palmert, M. R., Corona, G., Dohle, G. R., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0087-y · Cited by 286 · see citing works
Lessons From the Testosterone Trials
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00234 · Cited by 280 · see citing works
Self-citationFrailty and the endocrine system
Clegg, A. P., & Hassan-Smith, Z. K. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30110-4 · Cited by 273 · see citing works
Grossmann, M., & Matsumoto, A. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3580 · Cited by 246 · see citing works
Self-citationAssociation of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial
Roy, C. N., Snyder, P. J., Stephens-Shields, A. J., Artz, A. S., Bhasin, S., Cohen, H. J., Farrar, J. T., Gill, T. M., Zeldow, B., Cella, D., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9540 · Cited by 239 · see citing works
Self-citationObesity and cardiovascular health
Welsh, A., Hammad, M., Piña, I. L., & Kulinski, J. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae025 · Cited by 239 · see citing works
Resnick, S. M., Matsumoto, A. M., Stephens-Shields, A. J., Ellenberg, S. S., Gill, T. M., Shumaker, S. A., Pleasants, D. D., Barrett-Connor, E., Bhasin, S., Cauley, J. A., et al. (2017) · JAMA · doi:10.1001/jama.2016.21044 · Cited by 220 · see citing works
Self-citationSex Differences in Muscle Wasting
Anderson, L. J., Liu, H. M., & Garcia, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_9 · Cited by 222 · see citing works
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Testosterone replacement therapy and cardiovascular risk
Gagliano‐Jucá, T., & Basaria, S. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0211-4 · Cited by 197 · see citing works
Self-citationCurrent and investigational medications for the treatment of sarcopenia
Rolland, Y., Dray, C., Vellas, B., & Barreto, P. D. S. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155597 · Cited by 195 · see citing works
Corona, G., Giagulli, V. A., Maseroli, E., Vignozzi, L., Aversa, A., Zitzmann, M., Saad, F., Mannucci, E., & Maggi, M. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0480-2 · Cited by 185 · see citing works
Testosterone treatment and risk of venous thromboembolism: population based case-control study
Martinez, C., Suissa, S., Rietbrock, S., Katholing, A., Freedman, B., Cohen, A. T., & Handelsman, D. J. (2016) · BMJ · doi:10.1136/bmj.i5968 · Cited by 181 · see citing works
Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men
Walther, A., Breidenstein, J., & Miller, R. E. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2734 · Cited by 178 · see citing works
British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men—2017
Hackett, G. I., Kirby, M. G., Wylie, K. R., Heald, A. H., Ossei‐Gerning, N., Edwards, D., & Muneer, A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.01.023 · Cited by 175 · see citing works
Newman, C. B., Blaha, M. J., Boord, J. B., Cariou, B., Chait, A., Fein, H. G., Ginsberg, H. N., Goldberg, I. J., Murad, M. H., Subramanian, S., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa674 · Cited by 180 · see citing works
Storer, T. W., Basaria, S., Traustadottir, T., Harman, S. M., Pencina, K., Li, Z., Travison, T. G., Miciek, R., Tsitouras, P., Hally, K., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2771 · Cited by 174 · see citing works
Self-citationCheetham, T. C., An, J., Jacobsen, S. J., Niu, F., Sidney, S., Quesenberry, C. P., & Eeden, S. K. V. D. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9546 · Cited by 172 · see citing works
Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels
Cunningham, G. R., Stephens-Shields, A. J., Rosen, R. C., Wang, C., Bhasin, S., Matsumoto, A. M., Parsons, J. K., Gill, T. M., Molitch, M. E., Farrar, J. T., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1645 · Cited by 162 · see citing works
Self-citationthe Sarcopenia Guidelines Development group of the Belgian Society of Gerontology and Geriatrics (BSGG), De Spiegeleer, A., Beckwée, D., Bautmans, I., & Petrovic, M. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0566-y · Cited by 160 · see citing works
Hypogonadism and male obesity: Focus on unresolved questions
Grossmann, M. (2018) · Clinical Endocrinology · doi:10.1111/cen.13723 · Cited by 164 · see citing works
Hypogonadotropic Hypogonadism in Men With Diabesity
Dhindsa, S., Ghanim, H., Batra, M., & Dandona, P. (2018) · Diabetes Care · doi:10.2337/dc17-2510 · Cited by 158 · see citing works
Mitochondria as a Target for Mitigating Sarcopenia
Coen, P. M., Musci, R., Hinkley, J., & Miller, B. F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01883 · Cited by 140 · see citing works
Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology
Denlinger, C. S., Sanft, T. B., Baker, K. S., Baxi, S. S., Broderick, G. A., Demark‐Wahnefried, W., Friedman, D. L., Goldman, M. E., Hudson, M. M., Khakpour, N., et al. (2017) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.0146 · Cited by 154 · see citing works
Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis
Elliott, J., Kelly, S., Millar, A. C., Peterson, J., Chen, L., Johnston, A., Kotb, A., Skidmore, B., Bai, Z., Mamdani, M., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015284 · Cited by 151 · see citing works
Isidori, A. M., Aversa, A., Calogero, A. E., Ferlin, A., Francavilla, S., Lanfranco, F., Pivonello, R., Rochira, V., Corona, G., & Maggi, M. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01859-7 · Cited by 162 · see citing works
Testosterone, mood, behaviour and quality of life
Zitzmann, M. (2020) · Andrology · doi:10.1111/andr.12867 · Cited by 154 · see citing works
Ponce, O. J., Spencer-Bonilla, G., Alvarez-Villalobos, N., Serrano, V., Singh-Ospina, N., Rodriguez-Gutierrez, R., Salcido-Montenegro, A., Benkhadra, R., Prokop, L. J., Bhasin, S., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00404 · Cited by 148 · see citing works
Self-citationAging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 145 · see citing works
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism
Jayasena, C. N., Anderson, R. A., Llahana, S., Barth, J. H., MacKenzie, F., Wilkes, S., Smith, N., Sooriakumaran, P., Minhas, S., Wu, F. C. W., et al. (2022) · Clinical Endocrinology · doi:10.1111/cen.14633 · Cited by 147 · see citing works
Aging and sex hormones in males
Decaroli, M. C., & Rochira, V. (2016) · Virulence · doi:10.1080/21505594.2016.1259053 · Cited by 141 · see citing works
Hackett, G. I., Kirby, M. G., Edwards, D., Jones, T. H., Wylie, K. R., Ossei‐Gerning, N., David, J., & Muneer, A. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2017.10.067 · Cited by 145 · see citing works
Testosterone Treatment and Fractures in Men with Hypogonadism
Snyder, P. J., Bauer, D. C., Ellenberg, S. S., Cauley, J. A., Buhr, K. A., Bhasin, S., Miller, M. G., Khan, N., Li, X., & Nissen, S. E. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2308836 · Cited by 139 · see citing works
Self-citationTestosterone and Cardiovascular Risk: Meta-Analysis of Interventional Studies
Corona, G., Rastrelli, G., Di Pasquale, G., Sforza, A., Mannucci, E., & Maggi, M. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.04.641 · Cited by 138 · see citing works
Testosterone and sexual function in men
Rastrelli, G., Corona, G., & Maggi, M. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.04.004 · Cited by 137 · see citing works
The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health
Alemany, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911952 · Cited by 140 · see citing works
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130 · see citing works
Ng Tang Fui, M., Prendergast, L. A., Dupuis, P., Raval, M., Strauss, B. J., Zajac, J. D., & Grossmann, M. (2016) · BMC Medicine · doi:10.1186/s12916-016-0700-9 · Cited by 124 · see citing works
Yeap, B. B., Grossmann, M., McLachlan, R. I., Handelsman, D. J., Wittert, G. A., Conway, A. J., Stuckey, B. G., Lording, D. W., Allan, C. A., Zajac, J. D., et al. (2016) · Medical Journal of Australia · doi:10.5694/mja16.00393 · Cited by 135 · see citing works
Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis
Alexander, G. C., Iyer, G. S., Lucas, E. J., Lin, D. H., & Singh, S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.017 · Cited by 120 · see citing works
Bhasin, S., Apovian, C. M., Travison, T. G., Pencina, K., Moore, L. L., Huang, G., Campbell, W. W., Li, Z., Howland, A. S., Chen, R., et al. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.0008 · Cited by 113 · see citing works
Self-citationThe Role of Testosterone in the Elderly: What Do We Know?
Barone, B., Napolitano, L., Abate, M., Cirillo, L., Reccia, P., Passaro, F., Turco, C., Morra, S., Mastrangelo, F., Scarpato, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073535 · Cited by 120 · see citing works
The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials
Mohler, E. R., Ellenberg, S. S., Lewis, C. E., Wenger, N. K., Budoff, M. J., Lewis, M. R., Barrett-Connor, E. L., Swerdloff, R. S., Stephens‐Shields, A. J., Bhasin, S., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02243 · Cited by 116 · see citing works
Self-citationLayton, J. B., Kim, Y., Alexander, G. C., & Emery, S. (2017) · JAMA · doi:10.1001/jama.2016.21041 · Cited by 116 · see citing works
Hudson, J., Cruickshank, M., Quinton, R., Aucott, L. S., Aceves‐Martins, M., Gillies, K., Bhasin, S., Snyder, P. J., Ellenberg, S. S., Grossmann, M., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00096-4 · Cited by 114 · see citing works
Self-citationManagement of male erectile dysfunction: From the past to the future
Wang, C., Wu, B.-R., Xiang, P., Xiao, J., & Hu, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1148834 · Cited by 108 · see citing works
Self-citationFundamental Concepts Regarding Testosterone Deficiency and Treatment
Morgentaler, A., Zitzmann, M., Traish, A. M., Fox, A. W., Jones, T. H., Maggi, M., Arver, S., Aversa, A., Chan, J. C. N., Dobs, A. S., et al. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.04.007 · Cited by 106 · see citing works
Onasanya, O., Iyer, G. S., Lucas, E. J., Lin, D. H., Singh, S., & Alexander, G. C. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30215-7 · Cited by 104 · see citing works
Lopresti, A. L., Drummond, P. D., & Smith, S. J. (2019) · American Journal of Men s Health · doi:10.1177/1557988319835985 · Cited by 110 · see citing works
Aging of the endocrine system and its potential impact on sarcopenia
Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 106 · see citing works
T hrombotic issues in transgender medicine: A review
Shatzel, J. J., Connelly, K. J., & DeLoughery, T. G. (2016) · American Journal of Hematology · doi:10.1002/ajh.24593 · Cited by 101 · see citing works
Salonia, A., Adaikan, G., Buvat, J., Carrier, S., El-Meliegy, A., Hatzimouratidis, K., McCullough, A., Morgentaler, A., Torres, L. O., & Khera, M. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.324 · Cited by 100 · see citing works
Hormonal therapies and venous thrombosis: Considerations for prevention and management
Lavasseur, C. M., Neukam, S., Kartika, T., Bannow, B. S., Shatzel, J. J., & DeLoughery, T. G. (2022) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12763 · Cited by 103 · see citing works
Treatment of Men for “Low Testosterone”: A Systematic Review
Huo, S., Scialli, A. R., McGarvey, S., Hill, E., Tügertimur, B., Hogenmiller, A., Hirsch, A. I., & Fugh-Berman, A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162480 · Cited by 97 · see citing works
Handelsman, D. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab001 · Cited by 104 · see citing works
Debruyne, F. M. J., Behre, H. M., Roehrborn, C. G., Maggi, M., Wu, F. C. W., Schröder, F. H., Jones, T. H., Porst, H., Hackett, G. I., Wheaton, O. A., et al. (2016) · British Journal of Urology · doi:10.1111/bju.13578 · Cited by 97 · see citing works
Self-citationKhera, M., Broderick, G. A., Carson, C. C., Dobs, A. S., Faraday, M. M., Goldstein, I., Hakim, L. S., Hellstrom, W. J. G., Kacker, R., Köhler, T. S., et al. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.04.022 · Cited by 97 · see citing works
Hackett, G. I., Kirby, M. G., Rees, R. W., Jones, T. H., Muneer, A., Livingston, M. A., Ossei‐Gerning, N., David, J., Foster, J., Kalra, P. A., et al. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.221027 · Cited by 99 · see citing works
Testosterone replacement therapy: for whom, when and how?
Tsametis, C. P., & Isidori, A. M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.007 · Cited by 96 · see citing works
Pencina, K. M., Travison, T. G., Cunningham, G. R., Lincoff, A. M., Nissen, S. E., Khera, M., Miller, M. G., Flevaris, P., Li, X., Wannemuehler, K. A., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad484 · Cited by 98 · see citing works
Self-citationWhy does COVID‐19 kill more elderly men than women? Is there a role for testosterone?
Papadopoulos, V., Li, L., & Samplaski, M. K. (2020) · Andrology · doi:10.1111/andr.12868 · Cited by 94 · see citing works
Bauer, J. M., Cruz-Jentoft, A. J., Fielding, R. A., Kanis, J. A., Reginster, J.-Y., Bruyère, O., Cesari, M., Chapurlat, R., Al-Daghri, N., Dennison, E., et al. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00561-w · Cited by 83 · see citing works
Zuloaga, D. G., Heck, A., Guzman, R. M. D., & Handa, R. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00319-2 · Cited by 96 · see citing works
Hormones and Aging: An Endocrine Society Scientific Statement
Cappola, A. R., Auchus, R. J., Fuleihan, G. E., Handelsman, D. J., Kalyani, R. R., McClung, M. R., Stuenkel, C. A., Thorner, M. O., & Verbalis, J. G. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad225 · Cited by 102 · see citing works
Modifying Risk Factors in the Management of Erectile Dysfunction: A Review
DeLay, K. J., Haney, N. M., & Hellstrom, W. J. G. (2016) · The World Journal of Men s Health · doi:10.5534/wjmh.2016.34.2.89 · Cited by 93 · see citing works
Swerdloff, R. S., Wang, C., White, W. B., Kaminetsky, J. C., Gittelman, M., Longstreth, J. A., Dudley, R. E., & Danoff, T. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa238 · Cited by 87 · see citing works
Self-citationBhasin, S., Ellenberg, S. S., Storer, T. W., Basaria, S. S., Pahor, M., Stephens‐Shields, A. J., Cauley, J. A., Ensrud, K. E., Farrar, J. T., Cella, D. F., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30171-2 · Cited by 87 · see citing works
Self-citationSharma, R., Oni, O. A., Gupta, K., Sharma, M., Sharma, R., Singh, V., Parashara, D., Surineni, K., Dawn, B., Chen, G., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004880 · Cited by 86 · see citing works
Testosterone deficiency in men with Type 2 diabetes: pathophysiology and treatment
Gianatti, E., & Grossmann, M. (2019) · Diabetic Medicine · doi:10.1111/dme.13977 · Cited by 87 · see citing works
Bhasin, S., Lincoff, A. M., Basaria, S. S., Bauer, D. C., Boden, W. E., Cunningham, G. R., Davey, D. A., Dubcenco, E., Fukumoto, S., Garcia, M., et al. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.11.016 · Cited by 85 · see citing works
Self-citationSmooth Muscle Cell–Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With Aging
Kim, S. K., McCurley, A., DuPont, J. J., Aronovitz, M. A., Moss, M. E., Stillman, I. E., Karumanchi, S. A., Christou, D. D., & Jaffe, I. Z. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10437 · Cited by 84 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Haider, K. S., Haider, A., Doros, G. D., & Traish, A. M. (2017) · The Journal of Urology · doi:10.1016/j.juro.2017.07.039 · Cited by 82 · see citing works
Testosterone therapy and venous thromboembolism: A systematic review and meta-analysis
Houghton, D. E., Alsawas, M., Barrioneuvo, P., Tello, M., Farah, W. H., Beuschel, B., Prokop, L. J., Layton, J. B., Murad, M. H., & Moll, S. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.10.023 · Cited by 83 · see citing works
Mechanisms underlying the metabolic actions of testosterone in humans: A narrative review
Dandona, P., Dhindsa, S., Ghanim, H., & Saad, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14206 · Cited by 86 · see citing works
Free Testosterone: Pumping up the Tires or Ending the Free Ride?
Handelsman, D. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00171 · Cited by 78 · see citing works
Age and testosterone mediate influenza pathogenesis in male mice
Steeg, L. G. V., Vermillion, M. S., Hall, O. J., Alam, O., McFarland, R., Chen, H., Zirkin, B. R., & Klein, S. L. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00352.2016 · Cited by 77 · see citing works
Challenges and innovations of drug delivery in older age
Khan, M. S., & Roberts, M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.003 · Cited by 68 · see citing works
Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism
Bhasin, S., Travison, T. G., Pencina, K. M., O’Leary, M. P., Cunningham, G. R., Lincoff, A. M., Nissen, S. E., Lucia, M. S., Preston, M. A., Khera, M., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.48692 · Cited by 76 · see citing works
Self-citationPersonalized medicine in psychiatry
Wium‐Andersen, I. K., Vinberg, M., Kessing, L. V., & McIntyre, R. S. (2016) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2016.1216163 · Cited by 91 · see citing works
Santoro, N. F., Braunstein, G. D., Butts, C. L., Martin, K. A., McDermott, M., & Pinkerton, J. V. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1271 · Cited by 72 · see citing works
Steroid secretion in healthy aging
Fiacco, S., Walther, A., & Ehlert, U. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.035 · Cited by 71 · see citing works
Diem, S. J., Greer, N. L., MacDonald, R. H., McKenzie, L. G., Dahm, P., Ercan-Fang, N. G., Estrada, A., Hemmy, L. S., Rosebush, C. E., Fink, H. A., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m19-0830 · Cited by 72 · see citing works
Self-citation
- Authors
- Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., Ensrud, K. E., Lewis, C. E., Farrar, J. T., Cella, D., Rosen, R. C., Pahor, M., Crandall, J. P., Molitch, M. E., Cifelli, D., Dougar, D., Fluharty, L., Resnick, S. M., Storer, T. W., Anton, S., Basaria, S., Diem, S. J., Hou, X., Mohler, E. R., Parsons, J. K., Wenger, N. K., Zeldow, B., Landis, J. R., & Ellenberg, S. S.
- Affiliations
- University of Pennsylvania (US)
- Brigham and Women's Hospital (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- From the Division of Endocrinology, Diabetes, and Metabolism (P.J.S.), the Department of Biostatistics and Epidemiology (A.J.S.-S., J.T.F., X.H., B.Z., J.R.L., S.S.E.), the Center for Clinical Epidemiology and Biostatistics (D. Cifelli, D.D., L.F.), and the Division of Cardiovascular Disease, Section of Vascular Medicine, Department of Medicine (E.R.M.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Research Program in Men’s Health: Aging and Metabolism, Brigham and Women’s...
- University of Pittsburgh (US)
- Yale University (US)
- University of California San Diego (US)
- The Lundquist Institute (US)
- University of Minnesota (US)
- Northwestern University (US)
- New England Research Institutes (US)
- University of Florida (US)
- Albert Einstein College of Medicine (US)
- National Institutes of Health (US)
- Emory University (US)
- ORCID
- Snyder, Peter J.
- Bhasin, Shalender
- Cunningham, Glenn R.
- Matsumoto, Alvin M.
- Cauley, Jane A.
- Gill, Thomas M.
- Barrett-Connor, Elizabeth
- Swerdloff, Ronald S.
- Wang, Christina
- Ensrud, Kristine E.
- Lewis, Cora E.
- Farrar, John T.
- Cella, David
- Crandall, Jill P.
- Molitch, Mark E.
- Resnick, Susan M.
- Storer, Thomas W.
- Anton, Stephen
- Basaria, Shehzad
- Diem, Susan J.
- Hou, Xiaoling
- Parsons, J. Kellogg
- Wenger, Nanette K.
- Zeldow, Bret
- Landis, J. Richard
- Ellenberg, Susan S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-02-18
- Volume
- 374
- Issue
- 7
- Pages
- 611-624
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC5209754
- OpenAlex
- W2324158400
- Cited by
- 890
- References
- 40
- Citations by year
- 2026: 49 · 2025: 73 · 2024: 73 · 2023: 97 · 2022: 79 · 2021: 65 · 2020: 81 · 2019: 76 · 2018: 103 · 2017: 106 · 2016: 86
- FWCI
- 124.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p60dk079626-05, UL1TR000142)
- National Institute on Aging (U01AG030644, P30-AG013679, R01AG037679, K24AG021507, K07AG043587, R01 AG37679, P30AG024827, P30AG028740, P30AG021342)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK079626, P60-DK-079626, P30DK079626)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- testosterone replacement therapy, older men, hypogonadism, testosterone gel, sexual function, erectile function, sexual desire, physical function, walking distance, vitality, depressive symptoms, mood, adverse events
- MeSH terms
- Aged, Depression, Double-Blind Method, Fatigue, Humans, Libido, Male, Reference Values, Sexual Behavior, Testosterone, Walking, Prostate-Specific Antigen, Hormone Replacement Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
