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Clinical pharmacology and pharmacokinetics of clonidine
Abstract
A 300‐µg oral dose of clonidine was administered to 5 normal volunteers and measurements of plasma concentration and effects upon blood pressure, heart rate, circulatory reflexes, sedation, and dry mouth were made for the following 8 hr. The plasma concentration rose to a peak of 1.02 ± 0.52 ng/ml (SD) at 90 min andfell with a mean half‐life of 12.7 hr. Blood pressure of the group fell from 111.0/77.0 to 87.2/60.4 after 3 hr and was 95.2/62.2 mm Hg at 8 hr. Heart rate in recumbency was slowed. Marked sedation and a fall in sativary flow followed the same time‐course as the plasma concentration. The cold pressor response was reduced but the Valsalva overshoot was tiftle affected.
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Cited by
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Kobinger, W. (1978) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0034091 · Cited by 507
Influence of yohimbine on blood pressure, autonomic reflexes, and plasma catecholamines in humans.
Goldberg, M. R., Hollister, A. S., & Robertson, D. (1983) · Hypertension · doi:10.1161/01.hyp.5.5.772 · Cited by 127
Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity
Toce, M. S., Chai, P. R., Burns, M. M., & Boyer, E. W. (2018) · Journal of Medical Toxicology · doi:10.1007/s13181-018-0685-1 · Cited by 90
Metadata
- Authors
- Dollery, C. T., Davies, D. S., Draffan, G. H., Dargie, H. J., Dean, C. R., Reid, J. L., Clare, R. A., & Murray, S.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1976-01
- Volume
- 19
- Issue
- 1
- Pages
- 11-17
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W130740266
- Cited by
- 268
- References
- 0
- FWCI
- 19.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical pharmacology and pharmacokinetics of clonidine. https://app.cochat.ai/papers/10.1002/cpt197619111
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- Dollery, C. T., Davies, D. S., Draffan, G. H., Dargie, H. J., Dean, C. R., Reid, J. L., Clare, R. A., & Murray, S. (1976). Clinical pharmacology and pharmacokinetics of clonidine. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt197619111
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