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Toward the operational identification of adverse drug reactions
Abstract
The evaluation of adverse drug reactions in clinical practice is somewhat arbitrary and is characterized by considerable differences of opinion. This report presents a decision table algorithm approach toward the development of an operational system for the identification of adverse drug reactions. The algorithm incorporates an estimate of the certainty of the link between the untoward clinical event and the suspect drug, and examines the underlying causes of the identified drug reactions. Use of such a system is a first step toward reducing ambiguity in the evaluation of adverse drug reactions.
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Cited by
Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02397.x · Cited by 4,877
Danan, G., & Benichou, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90101-6 · Cited by 1,481
Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis
Oscanoa, T. J., Lizaraso, F., & Carvajal, A. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-017-2225-3 · Cited by 382
Methods for Causality Assessment of Adverse Drug Reactions: A Systematic Review
Agbabiaka, T. B., Savović, J., & Ernst, E. (2008) · Drug Safety · doi:10.2165/00002018-200831010-00003 · Cited by 366
Comparison of Two Clinical Scales for Causality Assessment in Hepatotoxicity
Lucena, M. I., Camargo, R., Andrade, R. J., Perez-Sanchez, C. J., & De La Cuesta, F. S. (2001) · Hepatology · doi:10.1053/jhep.2001.20645 · Cited by 212
Metadata
- Authors
- Karch, F. E., & Lasagna, L.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1977-03
- Volume
- 21
- Issue
- 3
- Pages
- 247-254
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2410676106
- Cited by
- 460
- References
- 0
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Karch, F. E., & Lasagna, L. (1977). Toward the operational identification of adverse drug reactions. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt1977213247
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