The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
Abstract
Summary: To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy. The overall framework of the definition has two “hierarchical” levels: Level 1 provides a general scheme to categorize response to each therapeutic intervention, including a minimum dataset of knowledge about the intervention that would be needed; Level 2 provides a core definition of drug resistant epilepsy using a set of essential criteria based on the categorization of response (from Level 1) to trials of antiepileptic drugs. It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. This definition can be further refined when new evidence emerges. The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided.
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Citations
Cites
Early Identification of Refractory Epilepsy
Kwan, P., & Brodie, M. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420503 · Cited by 5,204
Self-citationAdverse drug reactions: definitions, diagnosis, and management
Edwards, I. R., & Aronson, J. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02799-9 · Cited by 2,979
If nothing goes wrong, is everything all right? Interpreting zero numerators
Hanley, J. A. (1983) · JAMA · doi:10.1001/jama.249.13.1743 · Cited by 1,197
If Nothing Goes Wrong, Is Everything All Right?: Interpreting Zero Numerators
Hanley, J. A. (1983) · JAMA · doi:10.1001/jama.1983.03330370053031 · Cited by 1,043
Jacoby, A., Baker, G. A., Steen, N., Potts, P., & Chadwick, D. W. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb00006.x · Cited by 633
Toward the operational identification of adverse drug reactions
Karch, F. E., & Lasagna, L. (1977) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1977213247 · Cited by 460
Effectiveness of First Antiepileptic Drug
Kwan, P., & Brodie, M. J. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.04501.x · Cited by 432
Self-citationEarly development of intractable epilepsy in children: A prospective study
Berg, A. T., Shinnar, S., Levy, S. R., Testa, F. M., Smith–Rapaport, S., & Beckerman, B. (2001) · Neurology · doi:10.1212/wnl.56.11.1445 · Cited by 379
Self-citationDiagnosing refractory epilepsy: response to sequential treatment schedules
Mohanraj, R., & Brodie, M. J. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01215.x · Cited by 340
Self-citationResults of treatment changes in patients with apparently drug‐resistant chronic epilepsy
Luciano, A. L., & Shorvon, S. D. (2007) · Annals of Neurology · doi:10.1002/ana.21064 · Cited by 325
Cited by
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., Scheffer, I. E., Thiele, E. A., & Wright, S. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611618 · Cited by 1,711
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
The epidemiology of drug‐resistant epilepsy: A systematic review and meta‐analysis
Kalilani, L., Sun, X., Pelgrims, B., Noack‐Rink, M., & Villanueva, V. (2018) · Epilepsia · doi:10.1111/epi.14596 · Cited by 587
Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers
Tang, F., Hartz, A. M. S., & Bauer, B. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00301 · Cited by 482
Wilmshurst, J. M., Gaillard, W. D., Vinayan, K. P., Tsuchida, T. N., Plouin, P., Van Bogaert, P., Carrizosa, J., Elia, M., Craiu, D., Jovic, N. J., et al. (2015) · Epilepsia · doi:10.1111/epi.13057 · Cited by 418
Metadata
- Authors
- Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 51
- Issue
- 6
- Pages
- 1069-1077
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1920696238
- Cited by
- 4,877
- References
- 33
- FWCI
- 51.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kwan, P., Arzimanoglou, A., Berg, A. T., Brodie, M. J., Allen Hauser, W., Mathern, G., Moshé, S. L., Perucca, E., Wiebe, S., & French, J. (2010). Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. https://doi.org/10.1111/j.1528-1167.2009.02397.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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