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Metabolism of cocaine in man
Abstract
Following ingestion of [N‐14 CH 3]cocaine (10 mg, 2.3 µCi) by 2 healthy subjects, breath, saliva, serum, and urine samples were collected serially. Labeled CO 2 production was monitored as a measure of N‐demethylation of cocaine. The cumulative excretion of 14 CO 2 in 5 hr was 2.4% and 6.2% of the administered dose with half‐lives of 2.3 and 1.4 hr, respectively. The greater N‐demethylation was found in a subject with lower plasma cholinesterase activity. Radioactivity excreted in 0 to 28 hr urine reached 65% to 75% of the dose. Ecgonine methyl ester, a product of cocaine hydrolysis by plasma cholinesterase, was identified as a major metabolite in the urine of both subjects and accounted for 32% to 49% of the urinary metabolites.
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Citations
Cited by
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Masson, P., & Lockridge, O. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.12.005 · Cited by 233
Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma
Jenkins, A. J., Oyler, J. M., & Cone, E. J. (1995) · Journal of Analytical Toxicology · doi:10.1093/jat/19.6.359 · Cited by 181
Jufer, R. A., Wstadik, A., Walsh, S. L., Levine, B. S., & Cone, E. J. (2000) · Journal of Analytical Toxicology · doi:10.1093/jat/24.7.467 · Cited by 137
Cocaine Metabolism and Urinary Excretion After Different Routes of Administration
Cone, E. J., Tsadik, A., Oyler, J., & Darwin, W. D. (1998) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199810000-00019 · Cited by 112
Metadata
- Authors
- Inaba, T., Stewart, D. J., & Kalow, W.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1978-05
- Volume
- 23
- Issue
- 5
- Pages
- 547-552
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W270755921
- Cited by
- 251
- References
- 0
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Inaba, T., Stewart, D. J., & Kalow, W. (1978). Metabolism of cocaine in man. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt1978235547
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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