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Reduced β‐adrenoceptor sensitivity in the elderly
Abstract
The effect of age on sensitivity to both isoproterenol and propranolol has been investigated in 27 male volunteers aged 21 to 73 yr. The dose of isoproterenol (given as a rapid intravenous injection) required to increase the resting heart rate by 25 bpm (I 25) increased with age. The I 25 was repeated during an intravenous infusion of propranolol and the dose ratio (I 25 after propranolol divided by the control I 25) determined. This was related to the concentration of free propranolol in plasma. It was found that the effectiveness of any given free concentration diminished progressively with age. These data are consistent with a diminished responsiveness of the β‐adrenoceptor to both agonist and antagonist drugs with advancing years.
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Cited by
Aging Biology and Geriatric Clinical Pharmacology
McLean, A. J., & Le Couteur, D. G. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.4 · Cited by 771
Rodeheffer, R. J., Gerstenblith, G., Becker, L. C., Fleg, J. L., Weisfeldt, M. L., & Lakatta, E. G. (1984) · Circulation · doi:10.1161/01.cir.69.2.203 · Cited by 657
Greenblatt (1982) · doi:10.1056/nejm198205063061804 · Cited by 584
Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men
Stratton, J. R., Levy, W. C., Cerqueira, M. D., Schwartz, R. S., & Abrass, I. B. (1994) · Circulation · doi:10.1161/01.cir.89.4.1648 · Cited by 449
Maggioni, A. A., Maseri, A., Fresco, C., Franzosi, M. G., Mauri, F., Santoro, E., & Tognoni, G. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292002 · Cited by 396
Metadata
- Authors
- Vestal, R. E., Wood, A. J. J., & Shand, D. G.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1979-08
- Volume
- 26
- Issue
- 2
- Pages
- 181-186
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2414715525
- Cited by
- 612
- References
- 0
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduced β‐adrenoceptor sensitivity in the elderly. https://app.cochat.ai/papers/10.1002/cpt1979262181
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- Vestal, R. E., Wood, A. J. J., & Shand, D. G. (1979). Reduced β‐adrenoceptor sensitivity in the elderly. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt1979262181
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
