The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Aging Biology and Geriatric Clinical Pharmacology
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Citations
Cites
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785 · cited 1×
“No relationship has been found between age and the activities and content of various cytochrome P450 enzymes determined from microsomal preparations from liver resection specimens (Shimada et al., 1994).”
BackgroundLakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774
Harman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902
Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01059688 · Cited by 797 · cited 4×
“” On the other hand, the metabolism of poorly extracted medications is described as capacity-limited because it is influenced mostly by intrinsic clearance (the metabolizing capacity) and in some cases, protein binding (Branch et al., 1973; Wilkinson and Shand, 1975; Pang and Rowland, 1977).”
BackgroundInfluentialDoes oxidative damage to DNA increase with age?
Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768
Barazzoni, R., Short, K. R., & Nair, K. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3343 · Cited by 367
Genetic and functional changes in mitochondria associated with aging
Ozawa, T. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.425 · Cited by 312 · cited 1×
“Such respiratory chain defects lead to increased reactive oxygen species production, thus establishing a “vicious cycle” with aging (Papa, 1996; Ozawa, 1997).”
Background
Cited by
Pharmacokinetics and drug metabolism in the elderly
Klotz, U. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530902722679 · Cited by 826
Nobili, A., Garattini, S., & Mannucci, P. M. (2011) · Journal of Comorbidity · doi:10.15256/joc.2011.1.4 · Cited by 300
The clinical implications of ageing for rational drug therapy
Shi, S., Mörike, K., & Klotz, U. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0422-1 · Cited by 244
Drug Metabolism in Older People--A Key Consideration in Achieving Optimal Outcomes With Medicines
McLachlan, A. J., & Pont, L. G. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr118 · Cited by 172
Drug-induced liver injury in older people
Lucena, M. I., Sanabria, J., García-Cortes, M., Stephens, C., & Andrade, R. J. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(20)30006-6 · Cited by 77
Metadata
- Authors
- McLean, A. J., & Le Couteur, D. G.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 56
- Issue
- 2
- Pages
- 163-184
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2146270980
- Cited by
- 771
- References
- 9
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Aging Biology and Geriatric Clinical Pharmacology. https://app.cochat.ai/papers/10.1124/pr.56.2.4
- The paper
- McLean, A. J., & Le Couteur, D. G. (2004). Aging Biology and Geriatric Clinical Pharmacology. Pharmacological Reviews. https://doi.org/10.1124/pr.56.2.4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
