The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
2‐Methyltetrahydrofuran (2‐MeTHF): A Biomass‐Derived Solvent with Broad Application in Organic Chemistry
Abstract
2‐Methyl‐tetrahydrofuran (2‐MeTHF) can be derived from renewable resources (e.g., furfural or levulinic acid) and is a promising alternative solvent in the search for environmentally benign synthesis strategies. Its physical and chemical properties, such as its low miscibility with water, boiling point, remarkable stability compared to other cyclic‐based solvents such as THF, and others make it appealing for applications in syntheses involving organometallics, organocatalysis, and biotransformations or for processing lignocellulosic materials. Interestingly, a significant number of industries have also started to assess 2‐MeTHF in several synthetic procedures, often with excellent results and prospects. Likewise, preliminary toxicology assessments suggest that the use of 2‐MeTHF might even be extended to more processes in pharmaceutical chemistry. This Minireview describes the properties of 2‐MeTHF, the state‐of‐the‐art of its use in synthesis, and covers several outstanding examples of its application from both industry and academia.
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Cites
Synthesis of Transportation Fuels from Biomass: Chemistry, Catalysts, and Engineering
Huber, G. W., Iborra, S., & Corma, A. (2006) · Chemical Reviews · doi:10.1021/cr068360d · Cited by 7,664
Chemical Routes for the Transformation of Biomass into Chemicals
Corma, A., Iborra, S., & Velty, A. (2007) · Chemical Reviews · doi:10.1021/cr050989d · Cited by 5,970
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Anastas, P., & Eghbali, N. (2010) · Chem. Soc. Rev. · doi:10.1039/b918763b · Cited by 5,256
What is a green solvent? A comprehensive framework for the environmental assessment of solvents
Capello, C., Fischer, U., & Hungerbühler, K. (2007) · Green Chemistry · doi:10.1039/b617536h · Cited by 1,917
Green solvents for sustainable organic synthesis: state of the art
Sheldon, R. A. (2005) · Green Chemistry · doi:10.1039/b418069k · Cited by 1,711
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Asymmetric Aminocatalysis—Gold Rush in Organic Chemistry
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Henderson, R. K., Jiménez-González, C., Constable, D. J. C., Alston, S. R., Inglis, G. G. A., Fisher, G., Sherwood, J., Binks, S. P., & Curzons, A. D. (2011) · Green Chemistry · doi:10.1039/c0gc00918k · Cited by 1,140
Cited by
Green and sustainable solvents in chemical processes
Clarke, C. J., Tu, W.-C., Levers, O., Bröhl, A., & Hallett, J. P. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00571 · Cited by 2,071
Furfural: a renewable and versatile platform molecule for the synthesis of chemicals and fuels
Mariscal, R., Maireles-Torres, P., Ojeda, M., Sádaba, I., & López Granados, M. (2016) · Energy & Environmental Science · doi:10.1039/c5ee02666k · Cited by 1,642
Gu, Y., & Jérôme, F. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60241a · Cited by 668
Synthesis and utilisation of sugar compounds derived from lignocellulosic biomass
Kobayashi, H., & Fukuoka, A. (2013) · Green Chemistry · doi:10.1039/c3gc00060e · Cited by 489
Solvents and sustainable chemistry
Welton, T. (2015) · Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rspa.2015.0502 · Cited by 412
Metadata
- Authors
- Pace, V., Hoyos, P., Castoldi, L., Domínguez de María, P., & Alcántara, A. R.
- Venue
- ChemSusChem
- Publisher
- Wiley
- Published
- 2012-08
- Volume
- 5
- Issue
- 8
- Pages
- 1369-1379
- ISSN
- 1864-5631 (ISSN-L)
- 1864-564X
- OpenAlex
- W1974131570
- Cited by
- 699
- References
- 48
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 2‐Methyltetrahydrofuran (2‐MeTHF): A Biomass‐Derived Solvent with Broad Application in Organic Chemistry. https://app.cochat.ai/papers/10.1002/cssc.201100780
- The paper
- Pace, V., Hoyos, P., Castoldi, L., Domínguez de María, P., & Alcántara, A. R. (2012). 2‐Methyltetrahydrofuran (2‐MeTHF): A Biomass‐Derived Solvent with Broad Application in Organic Chemistry. ChemSusChem. https://doi.org/10.1002/cssc.201100780
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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