Autoantibodies against complement component C1q in systemic lupus erythematosus
Open accessAbstract
Systemic lupus erythematosus (SLE) is the archetype of a systemic autoimmune disease, but the multifaceted pathogenic mechanisms leading to inflammation and organ damage are not fully understood. Homozygous deficiency of complement C1q, the first component of the classical pathway of complement, is strongly associated with the development of SLE, thus pointing at a primarily protective role of C1q. However, while most SLE patients do not have hereditary C1q deficiency, there is indirect evidence for the importance of C1q in the inflammatory processes of the disease, including hypocomplementemia as a result of activation via the classical pathway, deposition of C1q in affected tissues and the occurrence of autoantibodies against C1q (anti‐C1q). The growing body of knowledge on anti‐C1q led to the establishment of a biomarker that is used in the routine clinical care of SLE patients. Exploring the binding characteristics of anti‐C1q allows to understand the mechanisms, that lead to the expression of relevant autoantigenic structures and the role of genetic as well as environmental factors. Lastly, the analysis of the pathophysiological consequences of anti‐C1q is of importance because C1q, the target of anti‐C1q, is a highly functional molecule whose downstream effects are altered by the binding of the autoantibody. This review summarises current study data on anti‐C1q and their implications for the understanding of SLE.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Routine detection of AMA is performed either by indirect immunofluorescence or ELISA.
“Routine detection of AMA is performed either by indirect immunofluorescence or ELISA (48).”
From Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus (2022) · cites this paper as [48]
The Characteristics of anti-C1q section describes an ELISA for detecting anti-C1q antibodies, not AMA. A search for AMA, antimitochondrial antibodies, and indirect immunofluorescence found no passage addressing the claimed routine detection methods. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Casciola-Rosen, L. A., Anhalt, G. J., & Rosen, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1317 · Cited by 1,723 · see citing works
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434 · see citing works
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148 · see citing works
Complement-dependent Clearance of Apoptotic Cells by Human Macrophages
Mevorach, D., Mascarenhas, J., Gershov, D., & Elkon, K. (1998) · Journal of Experimental Medicine · doi:10.1084/jem.188.12.2313 · Cited by 776 · see citing works
Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724 · see citing works
Korb, L. C., & Ahearn, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4525 · Cited by 659 · see citing works
Autoimmunity and organ damage in systemic lupus erythematosus
Tsokos, G. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0677-6 · Cited by 589 · see citing works
Systemic Lupus Erythematosus, Complement Deficiency, and Apoptosis
Pickering, M. C., Botto, M., Taylor, P. R., Lachmann, P. J., & Walport, M. J. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)76021-x · Cited by 538 · see citing works
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
McClain, M. T., Heinlen, L. D., Dennis, G. J., Roebuck, J., Harley, J. B., & James, J. A. (2004) · Nature Medicine · doi:10.1038/nm1167 · Cited by 442 · see citing works
Paleolog, E. M., Young, S., Stark, A. C., McCloskey, R. V., Feldmann, M., & Maini, R. N. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199807)41:7 · Cited by 318 · see citing works
Type I interferon in the pathogenesis of systemic lupus erythematosus
Postal, M., Vivaldo, J. F., Fernandez‐Ruiz, R., Paredes, J. L., Appenzeller, S., & Niewold, T. B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.10.014 · Cited by 309 · see citing works
Agnello, V., Koffler, D., Eisenberg, J. W., WINCHESTER, R. J., & Kunkel, H. G. (1971) · The Journal of Experimental Medicine · doi:10.1084/jem.134.3.228 · Cited by 303 · see citing works
C1q, Autoimmunity and Apoptosis
Botto, M. (2002) · Immunobiology · doi:10.1078/0171-2985-00141 · Cited by 291 · see citing works
Navratil, J. S., Watkins, S. C., Wisnieski, J. J., & Ahearn, J. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3231 · Cited by 262 · see citing works
Hypocomplementemic Urticarial Vasculitis Syndrome: Clinical and Serologic Findings in 18 Patients
Wisnieski, J. J., Baer, A. N., Christensen, J., Cupps, T. R., Flagg, D., Jones, J. V., Katzenstein, P. L., McFadden, E. R., McMillen, J. J., Pick, M. A., et al. (1995) · Medicine · doi:10.1097/00005792-199501000-00003 · Cited by 256 · see citing works
Structure and activation of the C1 complex of complement: unraveling the puzzle
Gaboriaud, C., Thielens, N. M., Gregory, L., Rossi, V., Fontecilla-Camps, J. C., & Arlaud, G. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.04.008 · Cited by 248 · see citing works
Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A., & Tenner, A. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103760 · Cited by 245 · see citing works
Trouw, L. A., Groeneveld, T. W. L., Seelen, M. A., Duijs, J. M. G. J., Bajema, I. M., Prins, F. A., Kishore, U., Salant, D. J., Verbeek, J. S., van Kooten, C., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421075 · Cited by 244 · see citing works
Trouw, L. A., Groeneveld, T. W. L., Seelen, M. A., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21075 · Cited by 207 · see citing works
Lood, C., Gullstrand, B., Truedsson, L., Olin, A. I., Alm, G. V., Rönnblom, L., Sturfelt, G. K., Eloranta, M., & Bengtsson, A. A. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24852 · Cited by 202 · see citing works
C1q restrains autoimmunity and viral infection by regulating CD8 <sup>+</sup> T cell metabolism
Ling, G. S., Crawford, G., Buang, N., Bartok, I., Tian, K., Thielens, N. M., Bally, I., Harker, J. A., Ashton-Rickardt, P. G., Rutschmann, S., et al. (2018) · Science · doi:10.1126/science.aao4555 · Cited by 199 · see citing works
Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis
Moroni, G. L., Trendelenburg, M., Papa, N. D., Quaglini, S., Raschi, E., Panzeri, P., Testoni, C., Tincani, A., Banfi, G., Balestrieri, G., et al. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.22071 · Cited by 181 · see citing works
Self-citationHigh prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis
Trendelenburg, M., López‐Trascasa, M., Potluková, E., Moll, S., Regenass, S., Frémeaux‐Bacchi, V., Martínez-Ara, J., Jančová, E., Picazo, M. L., Honsová, E., et al. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl436 · Cited by 180 · see citing works
Self-citationYing, S. C., Gewurz, A. T., Jiang, H., & Gewurz, H. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.1.169 · Cited by 167 · see citing works
Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
Bhatia, V. K., Yun, S., Leung, V. W. Y., Grimsditch, D. C., Benson, G. M., Botto, M., Boyle, J. J., & Haskard, D. O. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060406 · Cited by 166 · see citing works
Maturation of dendritic cells abrogates C1q production in vivo and in vitro
Castellano, G., Woltman, A. M., Nauta, A. J., Roos, A., Trouw, L. A., Seelen, M. A., Schena, F. P., Daha, M. R., & van Kooten, C. (2004) · Blood · doi:10.1182/blood-2003-09-3046 · Cited by 164 · see citing works
Fraser, D. A., Laust, A. K., Nelson, E. L., & Tenner, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902232 · Cited by 163 · see citing works
Bijl, M., Reefman, E., Horst, G., Limburg, P. C., & Kallenberg, C. G. M. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.035733 · Cited by 161 · see citing works
Siegert, C. E. H., Daha, M. R., Westedt, M. L., van der Voort, E., & Breedveld, F. C. (1991) · PubMed · Cited by 155 · see citing works
Santer, D. M., Hall, B. E., George, T. C., Tangsombatvisit, S., Liu, C. L., Arkwright, P. D., & Elkon, K. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001731 · Cited by 151 · see citing works
Intrarenal synthesis of complement
Zhou, W., Marsh, J. E., & Sacks, S. H. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041227.x · Cited by 144 · see citing works
Tas, S. W., Quartier, P., Botto, M., & Fossati-Jimack, L. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.037143 · Cited by 144 · see citing works
Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus.
Siegert, C. E. H., Daha, M. R., Tseng, C. M., Coremans, I. E. M., van Es, L. A., & Breedveld, F. C. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.12.851 · Cited by 134 · see citing works
McClain, M. T., Poole, B. D., Bruner, B. F., Kaufman, K. M., Harley, J. B., & James, J. A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21682 · Cited by 134 · see citing works
Wisnieski, J. J., & Jones, S. M. (1969) · Boletín Mexicano de Derecho Comparado · doi:10.22201/iij.24484873e.1969.4.609 · Cited by 132 · see citing works
Antes, U., Heinz, H., & Loos, M. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310401 · Cited by 125 · see citing works
Hanlon, P., Avenell, A., Aucott, L. S., & Vickers, M. A. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4429 · Cited by 119 · see citing works
Clinical presentation of human C1q deficiency: How much of a lupus?
Stegert, M., Bock, M., & Trendelenburg, M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.007 · Cited by 117 · see citing works
Self-citationUwatoko, S., & Mannik, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113684 · Cited by 117 · see citing works
Mannik, M., & Wener, M. H. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400819 · Cited by 111 · see citing works
Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments
Poole, B. D., Gross, T. F., Maier, S. M., Harley, J. B., & James, J. A. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.08.007 · Cited by 111 · see citing works
DNA binds and activates complement via residues 14-26 of the human C1q A chain.
Jiang, H., Cooper, B. J., Robey, F. A., & Gewurz, H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74082-4 · Cited by 109 · see citing works
Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation.
Chen, A., Gaddipati, S., Hong, Y., Volkman, D. J., Peerschke, E. I. B., & Ghebrehiwet, B. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1430 · Cited by 106 · see citing works
Jiang, H., Robey, F. A., & Gewurz, H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.5.1373 · Cited by 106 · see citing works
Reid, K. B. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00764 · Cited by 102 · see citing works
Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles
Haseley, L. A., Wisnieski, J. J., Denburg, M., Michael-Grossman, A. R., Ginzler, E. M., Gourley, M. F., Hoffman, J. H., Kimberly, R. P., & Salmon, J. E. (1997) · Kidney International · doi:10.1038/ki.1997.464 · Cited by 98 · see citing works
Antibodies against C1q in patients with systemic lupus erythematosus
Trendelenburg, M. (2005) · Springer Seminars in Immunopathology · doi:10.1007/s00281-005-0007-y · Cited by 93 · see citing works
Self-citationGolan, M. D., Bürger, R., & Loos, M. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.2.445 · Cited by 90 · see citing works
Immunohistopathologic Evaluation of C1q in 800 Renal Biopsy Specimens
Jennette, J. C., & Hipp, C. G. (1985) · American Journal of Clinical Pathology · doi:10.1093/ajcp/83.4.415 · Cited by 88 · see citing works
Wisnieski, J. J., & Jones, S. M. (1992) · PubMed · Cited by 87 · see citing works
Cardiogenic hypertrophic osteoarthropathy.
Siegert, C. E., Daha, M. R., Halma, C., van der Voort, E. A., & Breedveld, F. C. (1992) · PubMed · Cited by 82 · see citing works
Cell death in the diseased glomerulus
Harrison, D. J. (1988) · Histopathology · doi:10.1111/j.1365-2559.1988.tb01995.x · Cited by 81 · see citing works
IgG and IgA antibodies to the collagen‐like region of C1q in rheumatoid vasculitis
Siegert, C. E. H., Daha, M. R., der Voort, E. A. M. P.-V., & Breedveld, F. C. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780331107 · Cited by 78 · see citing works
Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells
Bigler, C., Schaller, M. M., Perahud, I., Osthoff, M. F., & Trendelenburg, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803573 · Cited by 77 · see citing works
Self-citationDendritic cells in the arterial wall express C1q: potential significance in atherogenesis
Cao, W. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00345-6 · Cited by 73 · see citing works
Antibodies Elicited in Response to EBNA-1 May Cross-React with dsDNA
Yadav, P. D., Tran, H., Ebegbe, R., Gottlieb, P., Wei, H. A., Lewis, R. H., Mumbey-Wafula, A., Kaplan, A., Kholdarova, E., & Spatz, L. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014488 · Cited by 69 · see citing works
Horváth, L., Czirják, L., Fekete, B., Jakab, L., Pozsonyi, T., Kalabay, L., Romics, L., Miklós, K., Varga, L. Á., Prohászka, Z., et al. (2001) · PubMed · Cited by 68 · see citing works
Anti-C1q Antibodies as a Follow-Up Marker in SLE Patients
Bock, M., Heijnen, I., & Trendelenburg, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123572 · Cited by 64 · see citing works
Self-citationRenal Macrophages and Dendritic Cells in SLE Nephritis
Maria, N. I., & Davidson, A. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0708-y · Cited by 63 · see citing works
Trouw, L. A., Seelen, M. A., Duijs, J. M. G. J., Benediktsson, H., van Kooten, C., & Daha, M. R. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02108.x · Cited by 62 · see citing works
Castellano, G., Trouw, L. A., Fiore, N., Daha, M. R., Schena, F., & van Kooten, C. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.006 · Cited by 57 · see citing works
Santer, D. M., WIEDEMAN, A. E., Teal, T. H., Ghosh, P., & Elkon, K. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102797 · Cited by 57 · see citing works
Pang, Y., Yang, X.-W., Song, Y., Yu, F., & Zhao, M. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.07.004 · Cited by 53 · see citing works
Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits
Uwatoko, S., Gauthier, V., & Mannik, M. (1991) · Clinical Immunology and Immunopathology · doi:10.1016/s0090-1229(05)80030-3 · Cited by 53 · see citing works
Prada, A. E., & Strife, C. F. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90097-8 · Cited by 53 · see citing works
Siegert, C. E. H., Daha, M. R., Swaak, A. J. G., Voort, E. A. M. V. D., & Breedveld, F. C. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1066 · Cited by 53 · see citing works
Autoantibodies against C1q in Systemic Lupus Erythematosus Are Antigen-Driven
Schaller, M. M., Bigler, C., Danner, D., Ditzel, H. J., & Trendelenburg, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902642 · Cited by 53 · see citing works
Self-citationHypocomplementemic urticarial vasculitis or systemic lupus erythematosus?
Trendelenburg, M., Courvoisier, S., Späth, P., Moll, S., Mihatsch, M. J., Itin, P. H., & Schifferli, J. A. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70402-6 · Cited by 52 · see citing works
Self-citationGunnarsson, I., Rönnelid, J., Huang, Y., Rogberg, S., Nilsson, B., Lundberg, I. E., & Klareskog, L. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.1.32 · Cited by 52 · see citing works
Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus
Martin, M., Smoląg, K. I., Björk, A., Gullstrand, B., Okrój, M., Leffler, J., Jönsen, A., Bengtsson, A. A., & Blom, A. M. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1470-2 · Cited by 52 · see citing works
Frémeaux‐Bacchi, V., Weiss, L., Demouchy, C., Blouin, J., & Kazatchkine, M. D. (1996) · Lupus · doi:10.1177/096120339600500309 · Cited by 49 · see citing works
Csorba, K., Schirmbeck, L. A., Tuncer, E., Ribi, C., Roux‐Lombard, P., Chizzolini, C., Huynh‐Do, U., Vanhecke, D., & Trendelenburg, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02619 · Cited by 48 · see citing works
Self-citationUltraviolet-Radiation-Induced Keratinocyte Apoptosis in C1q-Deficient Mice
Pickering, M. C., Fischer, S., Lewis, M., Walport, M. J., Botto, M., & Cook, H. T. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01381.x · Cited by 46 · see citing works
Mårtensson, U., Sjöholm, A. G., Sturfelt, G. K., Truedsson, L., & Laurell, A. (1992) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1992.tb02982.x · Cited by 46 · see citing works
Sjöwall, C., Olin, A. I., Skogh, T., Wetterö, J., Mörgelin, M., Nived, O., Sturfelt, G. K., & Bengtsson, A. A. (2013) · Autoimmunity · doi:10.3109/08916934.2013.764992 · Cited by 43 · see citing works
Vanhecke, D., Roumenina, L. T., Wan, H., Osthoff, M. F., Schaller, M. M., & Trendelenburg, M. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34605 · Cited by 42 · see citing works
Self-citationIsolation and characterization of maerophage‐derived C1q and its similarities to serum C1q
Rabs, U., Martin, H., Hitschold, T., Golan, M. D., Heinz, H., & Loos, M. (1986) · European Journal of Immunology · doi:10.1002/eji.1830160926 · Cited by 42 · see citing works
Tsacheva, I., Radanova, M. A., Todorova, N. H., Аргирова, Т., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.09.009 · Cited by 40 · see citing works
Thanei, S., Vanhecke, D., & Trendelenburg, M. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.06.014 · Cited by 38 · see citing works
Self-citationClinical Value of Autoantibodies Against C1q in Children With Glomerulonephritis
Kazyra, I. A., Perahud, I., Sadallah, S., Sukalo, A. V., Titov, L. P., Schifferli, J. A., & Trendelenburg, M. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1148 · Cited by 38 · see citing works
Self-citationSjöholm, A. G., Mårtensson, U., & Sturfelt, G. K. (1997) · PubMed · Cited by 34 · see citing works
Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling
Kölm, R., Schaller, M. M., Roumenina, L. T., Niemiec, I., Hovinga, J. A. K., Khanicheh, E., Kaufmann, B. A., Hopfer, H., & Trendelenburg, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501876 · Cited by 33 · see citing works
Self-citationZhao, N., Wu, J., Xiong, S., Zhang, L., Lu, X., Chen, S., Wu, Q., Wang, H., Liu, Y., Chen, Z., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201601200rr · Cited by 33 · see citing works
Thanei, S., & Trendelenburg, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501659 · Cited by 31 · see citing works
Self-citation“Kill” the messenger: Targeting of cell-derived microparticles in lupus nephritis
Nielsen, C. T., Rasmussen, N. S., Heegaard, N. H. H., & Jacobsen, S. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.03.009 · Cited by 30 · see citing works
Donat, C., Thanei, S., & Trendelenburg, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02712 · Cited by 28 · see citing works
Self-citationPang, Y., Tan, Y. C. R. S., Li, Y., Zhang, J., Guo, Y., Guo, Z., Zhang, C., Yu, F., & Zhao, M. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.010 · Cited by 27 · see citing works
Siegert, C. E. H., Daha, M. R., Lobatto, S., Voort, E. A. M. V. D., & Breedveld, F. C. (1992) · Immunologic Research · doi:10.1007/bf02918613 · Cited by 26 · see citing works
Potluková, E., Jiskra, J., Limanova, Z., Králíková, P., Smutek, D., Marečková, H., Antošová, M., & Trendelenburg, M. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03670.x · Cited by 25 · see citing works
Self-citationKoenig, K., Ribi, C., Radosavac, M., Zulewski, H., Trendelenburg, M., & (SSCS), S. S. C. S. (2014) · Lupus · doi:10.1177/0961203314550223 · Cited by 24 · see citing works
Self-citationAutoantibodies against complement C1q in acute post-streptococcal glomerulonephritis
Kazyra, I. A., Коростелева, Л. Б., Chernoshej, D., Danner, D., Sukalo, A. V., & Trendelenburg, M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.04.005 · Cited by 22 · see citing works
Self-citationMårtensson, U., Thiel, S., Jensenius, J. C., & Sjöholm, A. G. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-48.x · Cited by 22 · see citing works
Hunnangkul, S., Nitsch, D., Rhodes, B., Chadha, S., Roberton, C. A., Pessôa‐Lopes, P., Norsworthy, P. J., Fernando, M. M. A., Charles, P. J., Mackworth-Young, C. G., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23400 · Cited by 18 · see citing works
Thanei, S., & Trendelenburg, M. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a1215-535r · Cited by 17 · see citing works
Self-citationRenal cell apoptosis in human lupus nephritis: a histological study
Faurschou, M., Penkowa, M., Andersen, C. Y., Starklint, H., & Jacobsen, S. (2009) · Lupus · doi:10.1177/0961203309106175 · Cited by 14 · see citing works
Wu, W., Tan, Y., Liu, X., Yu, F., & Zhao, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00848 · Cited by 11 · see citing works
Functional domains of the human C1q A-chain.
Trinder, P. K. E., Maeurer, M. J., Kaul, M., Petry, E., & Loos, M. (1993) · PubMed · Cited by 10 · see citing works
Ghebrehiwet, B., Kandov, E., Kishore, U., & Peerschke, E. I. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00162 · Cited by 10 · see citing works
Some Speculations on the Origins of Autoantibodiesa
Schwartz, R. S. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb51278.x · Cited by 6 · see citing works
- Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [48]Siegert CE, Daha MR, Halma C, van der Voort EA, Breedveld FC. IgG and IgA autoantibodies to C1q in systemic and renal diseases. Clin Exp Rheumatol 1992; 10: 19– 23. 1348021
Cited by
Sorted by citations
Complement as a Biomarker for Systemic Lupus Erythematosus
Ayano, M., & Horiuchi, T. (2023) · Biomolecules · doi:10.3390/biom13020367 · Cited by 100 · see citing works
Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells
Bigler, C., Schaller, M. M., Perahud, I., Osthoff, M. F., & Trendelenburg, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803573 · Cited by 77 · see citing works
Self-citationGoldbach‐Mansky, R. T., Alehashemi, S., & de Jesus, A. A. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01184-8 · Cited by 47 · see citing works
Expanding Horizons in Complement Analysis and Quality Control
Frazer‐Abel, A. A., Kirschfink, M., & Prohászka, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697313 · Cited by 42 · see citing works
Understanding the contextual functions of C1q and LAIR-1 and their applications
Son, M. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00774-4 · Cited by 42 · see citing works
Anti-C1q antibodies: a biomarker for diagnosis and management of lupus nephritis. A narrative review
Calatroni, M., Moroni, G. L., Conte, E., Stella, M., Reggiani, F., & Ponticelli, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1410032 · Cited by 27 · see citing works
Becker, Y. L. C., Gagné, J., Julien, A., Lévesque, T., Allaeys, I., Gougeard, N., Rubio, V., Boisvert, F., Jean, D., Wagner, E., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42082 · Cited by 26 · see citing works
Autoantibodies in Systemic Lupus Erythematosus: Diagnostic and Pathogenic Insights
Pagkopoulou, E., Loutradis, C., Papaioannou, M., Daoudaki, M., Stangou, M. J., & Dimitroulas, T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14165714 · Cited by 24 · see citing works
Karlsson, J., Wetterö, J., Weiner, M., Rönnelid, J., Fernandez-Botrán, R., & Sjöwall, C. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02831-9 · Cited by 23 · see citing works
Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse
Gaboriaud, C., Lorvellec, M., Rossi, V., Dumestre‐Pérard, C., & Thielens, N. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869720 · Cited by 23 · see citing works
Radanova, M. A., Vasilev, V. V., Mihaylova, G., Kosturkova, M., Kishore, U., & Roumenina, L. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169281 · Cited by 19 · see citing works
Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases
Li, Q., Liu, H., Yin, G., & Xie, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28399 · Cited by 17 · see citing works
Castro‐Marrero, J., Zacarés, M., Almenar‐Pérez, E., Alegre, J., & Oltra, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184171 · Cited by 15 · see citing works
The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases
Nasonov, E. L., Avdeeva, A. S., Reshetnyak, T. M., Aleksankin, A. P., & Rubtsov, Y. P. (2023) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2023-513-530 · Cited by 15 · see citing works
Heijke, R., Ahmad, A., Frodlund, M., Wirestam, L., Dahlström, Ö., Dahle, C., Kechagias, S., & Sjöwall, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173820 · Cited by 12 · see citing works
Overview on the role of complement-specific autoantibodies in diseases
Matola, A. T., Józsi, M., & Uzonyi, B. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.08.011 · Cited by 11 · see citing works
Larsen, M. L., Troldborg, A., Toonen, E. J. M., Hurler, L., Prohászka, Z., Cervenak, L., Hansen, A. G., & Thiel, S. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad070 · Cited by 7 · see citing works
Jia, Z., Yu, W., Li, J., Zhang, M., Zhan, B., Yan, L., Ming, Z., Cheng, Y., Tian, X., Shao, S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1404752 · Cited by 7 · see citing works
Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review
Lyu, Q., Zou, H., & Hu, S. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09119-1 · Cited by 5 · see citing works
Lan, W., Lu, Q., Jiang, Z., Ma, W., Hou, L., Li, D., Rui, X., & Tang, F. (2026) · iScience · doi:10.1016/j.isci.2026.115738 · Cited by 5 · see citing works
Early diagnosis and clinical application of systemic lupus erythematosus based on a nomogram model
Yang, Y., Huang, D., Liu, C., Zhong, N., Peng, Y., Wang, L., Xiao, L., & Zhao, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24523 · Cited by 4 · see citing works
Maueröder, C., Gillis, C. M., & Ravichandran, K. S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-92785-0_2 · Cited by 5 · see citing works
Genes, Antibodies, and Cytokines in Systemic Lupus Erythematosus: Update of Potential Biomarkers
Zaripova, L. N., Baigenzhin, A. K., Boltanova, A., Iglikov, T., Solomadin, M., Makimova, D., Kozina, L., & Chuvakova, E. (2024) · Journal of Clinical Medicine of Kazakhstan · doi:10.23950/jcmk/14641 · Cited by 4 · see citing works
Zeb, R., Chinome, D. V. C., Chacon, M., Singh, T., Chowdary, M. M., Vidals, C. J. M., Mehnaz, S., Medina, A. F. T., Gadde, P. S., lingamgunta, R. P. K., et al. (2024) · Cureus · doi:10.7759/cureus.76478 · Cited by 3 · see citing works
Cholakova, G., Stankova, S., Kapogianni, A., Gendzhova, M., Ivanova, D., Petrova, S., & Tsacheva, I. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e130210 · Cited by 1 · see citing works
Xie, S., Liang, Y., Zhu, W., Jia, X., Wei, Q., Zhou, W., Lu, C., & Jiang, Y. (2025) · Lupus Science & Medicine · doi:10.1136/lupus-2025-001701 · Cited by 1 · see citing works
Tuncer, E., Moll, S., Dubler, D., Schulz, K., & Trendelenburg, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1710424 · Cited by 1 · see citing works
Self-citationClinical implications and mechanism of complement C1q in polymyositis
Wu, D., Cui, Y., Cao, Y., Wang, Y., Zhang, J., Guo, Y., & Yuan, B. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04692-7 · Cited by 1 · see citing works
Davidson, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93232-5.00029-0 · Cited by 1 · see citing works
Gómez-Sifontes, A. E., Diaz-Tablero, J. A., & Rodriguez, Y. J. G. G. (2025) · OALib · doi:10.4236/oalib.1112987 · Cited by 1 · see citing works
Clinical Importance of C1q Antibodies in Systemic Lupus Patients With and Without Nephritis
Salah, M. A., mahdy, A., Rashed, S., & Zahran, A. (2022) · Journal of Recent Advances in Medicine/Journal of Recent Advances in Medicine · doi:10.21608/jram.2022.142823.1171
Early Diagnosis and Clinical Application of Systemic Lupus 2 Erythematosus Based on Nomograph ModelPreprint
Yang, Y.-L., Zhao, W., Xiao, L., Liu, C., Huang, D., Peng, Y., & Wang, L. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4486887
Abnormalities in clearance of immune complexes and dying cells in lupus
Su, V. L., & Means, T. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93232-5.00025-3
Molina, V., Gómez-Galán, M. A., Mejía, M., Toquica, A., & Bernal‐Macías, S. (2024) · Lupus · doi:10.1177/09612033241253156
Markers of Autoimmune Rheumatic Diseases
Baldovino, S., Cecchi, I., Radin, M., & Menegatti, E. (2024) · Rare diseases of the immune system · doi:10.1007/978-3-031-60855-1_20
Fava, A., Wagner, C. A., & James, J. A. (2024) · Arthritis & Rheumatology · doi:10.1002/art.43033
Jost, L., Helmchen, B., Osthoff, M. F., & Nigg, L. (2024) · Cureus · doi:10.7759/cureus.72113
Kleer, J. S., Kieninger‐Gräfitsch, A., Chizzolini, C., Huynh‐Do, U., Ribi, C., & Trendelenburg, M. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70028
Self-citationAtanasova, A., Cholakova, G., Kapogianni, A., Donev, V., Ivanova, D., Yordanova, A. D., Bogoeva, V. P., & Tsacheva, I. (2025) · Antibodies · doi:10.3390/antib14040094
Karlsson, J., Wetterö, J., Weiner, M., Rönnelid, J., Fernandez-Botran, R., & Sjöwall, C. (2022) · Figshare · doi:10.6084/m9.figshare.20056769
Karlsson, J., Wetterö, J., Weiner, M., Rönnelid, J., Fernandez-Botran, R., & Sjöwall, C. (2022) · Figshare · doi:10.6084/m9.figshare.20056763
Karlsson, J., Wetterö, J., Weiner, M., Rönnelid, J., Fernandez-Botran, R., & Sjöwall, C. (2022) · Figshare · doi:10.6084/m9.figshare.20056766
Holzhausen, F., Spitzenberg, C., Pauly, D., & Baeumner, A. J. (2026) · Talanta · doi:10.1016/j.talanta.2026.130079
Al-Karawi, A. S., & Kadhim, A. S. (2026) · Human Immunology · doi:10.1016/j.humimm.2026.112039
Chougule, D., Jose, A., Jamale, T., Mehta, K. C., Rajadhyaksha, A., Bajpai, D., Thakare, S. B., Madkaikar, M. R., & Pradhan, V. (2026) · Immunobiology · doi:10.1016/j.imbio.2026.153246
Pisetsky, D. S., Zhao, Y., Engelhard, M., Eudy, A. M., Tedeschi, P., O’Malley, T., Alexander, R. V., Clowse, M., Criscione‐Schreiber, L. G., Doss, J., et al. (2026) · Clinical Immunology · doi:10.1016/j.clim.2026.110779
Mathematical model of the chronic stage of SLE including the complement protein C1q
Suvandjieva, V., Acotto, F., Tsacheva, I., & Rashkov, P. (2026) · Mathematical Biosciences · doi:10.1016/j.mbs.2026.109832
- Authors
- Trendelenburg, M.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Trendelenburg, Marten
- Venue
- Clinical & Translational Immunology
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 10
- Issue
- 4
- Pages
- e1279-e1279
- ISSN
- 2050-0068 (ISSN-L)
- PMC
- PMC8082710
- OpenAlex
- W3158333192
- Cited by
- 48
- References
- 101
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 5 · 2022: 10 · 2021: 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical & Translational Immunology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (172965, 310030)
- Idorsia Pharmaceuticals
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- systemic lupus erythematosus, C1q, anti-C1q autoantibodies, C1q deficiency, classical complement pathway, hypocomplementemia, autoantigens, biomarkers, lupus pathogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
