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Cited by 7Breast Lesions and CarcinomasAI in cancer detectionThyroid Cancer Diagnosis and Treatment

The diagnostic utility of cell block in fine needle aspiration cytology of palpable breast lesions in a Nigerian tertiary health institution

Obiajulu, Fred John Nnaemeka, Daramola, Adetola Olubunmi, Anunobi, Charles Chidozie, Ikeri, Nzechukwu Zimudo, Abdulkareem, Fatimah Biade, Banjo, Adekunbiola Aina·2020·Diagnostic Cytopathology
DOI 10.1002/dc.24576
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Abstract

Background: Although fine needle aspiration cytology (FNAC) is highly accurate for detecting breast malignancies, concerns remain among cytopathologists about false‐positive and false‐negative diagnoses. Cell block (CB) preparations have been advocated by some cytopathologists as one of the methods to improve and consolidate the diagnostic accuracy of FNAC. The aim of this study was to determine the diagnostic utility of CB in FNAC of palpable breast lesions among female patients. Methods: Following FNA, CBs were prepared using 10% neutral‐buffered formalin from the residual breast aspirates of 100 consecutive female patients attending the FNAC clinic. The slides of the conventional smears, CB and excisional biopsies were examined, and results were analysed using the SPSS. Results: Of the 100 patients that had FNAC, 44 (44%) had excisional biopsy performed. An additional 13% diagnostic yield for malignancy was obtained with the use of CB preparations. CB reduced equivocal diagnoses by 25%, corresponding with 90.9% improvement on definitive diagnoses. Conclusion: In our setting, the addition of CB to smear remarkably improved the diagnostic utility of breast FNAC by minimising atypical and suspicious for malignancy diagnostic categories.

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  • FNAB has been further implemented in numerous LMICs for diagnosis and guiding clinical management of palpable breast lesions.

    “With the success of the FNAB in diagnosis and guiding clinical management of palpable breast lesions, this biopsy method has been further implemented in numerous LMICs.[30][31][32][33][34][35]”

    From Fine needle aspiration biopsy in low‐ and <scp>middle‐income</scp> countries (2024) · cites this paper as [35]

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Authors
Obiajulu, F. J. N., Daramola, A. O., Anunobi, C. C., Ikeri, N. Z., Abdulkareem, F. B., & Banjo, A. A.
Affiliations
  • Lagos University Teaching Hospital (NG)
  • University of Lagos (NG)
Corresponding author
Obiajulu, Fred John Nnaemeka
ORCID
Venue
Diagnostic Cytopathology
Publisher
Wiley
Published
2020-08-11
Volume
48
Issue
12
Pages
1300-1306
ISSN
  • 1097-0339 (ISSN-L)
  • 8755-1039
DOI
10.1002/dc.24576
OpenAlex
W3048796838
Cited by
7
References
27
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diagnostic Cytopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
cell block, fine needle aspiration cytology, palpable breast lesions, breast cancer diagnosis, diagnostic accuracy, equivocal cytology, excisional biopsy, Nigerian patients
MeSH terms
Adult, Breast, Breast Neoplasms, Cytodiagnosis, False Negative Reactions, Female, Humans, Nigeria, Prospective Studies, Sensitivity and Specificity, Biopsy, Fine-Needle

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