Effects of glucocorticoids on carbohydrate metabolism
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Claims the paper makes
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The mechanism(s) responsible for cortisol-induced insulin resistance are poorly understood.
“However, the mechanism(s) responsible for cortisolinduced insulin resistance are poorly understood (28,41).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [28]
Excess cortisol induces hepatic and extrahepatic insulin resistance and alters insulin action.
“Previous studies have demonstrated that excess cortisol induces hepatic and extrahepatic insulin resistance (3,18,20,28,41,42,48).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [28]
Cortisol impairs insulin sensitivity with a latency of four to six hours.
“Cortisol impairs insulin sensitivity with a latency of four to six hours.56,58,59”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [58]
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References 121 · Cited by 390
- Authors
- Mcmahon, M., Gerich, J., & Rizza, R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Rizza, R.
- ORCID
- Mcmahon, M.
- Venue
- Diabetes/Metabolism Reviews
- Publisher
- Wiley
- Published
- 1988-02
- Volume
- 4
- Issue
- 1
- Pages
- 17-30
- ISSN
- 0742-4221 (ISSN-L)
- 1099-0895
- OpenAlex
- W1993073314
- Semantic Scholar
- 5291debdecf7c68c09a79ffeb76c6063c774cbd7
- Cited by
- 390
- References
- 121
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 9 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 18 · 2015: 16 · 2014: 10 · 2013: 25 · 2012: 15
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes/Metabolism Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am020411-09, AM29957)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- glucocorticoids, carbohydrate metabolism, glucose metabolism
- MeSH terms
- Insulin Secretion, Animals, Diabetes Mellitus, Glucagon, Glucocorticoids, Humans, Insulin, Liver, Carbohydrate Metabolism
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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