Early‐onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

Bo, A.; Thomsen, R.W.; Nielsen, J.S.; Nicolaisen, S.K.; Beck‐Nielsen, H.; Rungby, J.; Sørensen, H.T.; Hansen, T.K.; Søndergaard, J.; Friborg, S.; Lauritzen, T.; Maindal, H.T.

doi:10.1002/dmrr.2968

Cited by 62Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

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Early‐onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

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Bo, A., Thomsen, R.W., Nielsen, J.S., Nicolaisen, S.K., Beck‐Nielsen, H., Rungby, J., Sørensen, H.T., Hansen, T.K., Søndergaard, J., Friborg, S., Lauritzen, T., Maindal, H.T.·2018·Diabetes/Metabolism Research and Reviews

DOI 10.1002/dmrr.2968

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Abstract

Aim: To examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioural risk factors for later complications of diabetes. Methods: We conducted a cross‐sectional study of 5115 persons with incident type 2 DM enrolled during 2010‐2015 in the Danish Centre for Strategic Research in Type 2 Diabetes‐cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early onset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years (late onset). Prevalence ratios (PRs) were computed by using Poisson regression. Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0%) in the early‐, average‐, and late‐onset groups was observed in 12%, 7%, and 1%, respectively (PR 1.70 [95% confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95% CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m 2: 19% vs. 8% vs. 2%; PR 2.41 [95% CI 1.83, 3.18] and 0.21 (95% CI 0.08, 0.57]), dyslipidemia (90% vs. 79% vs. 68%; PR 1.14 [95% CI 1.10, 1.19] and 0.86 [95% CI 0.79, 0.93]), and low‐grade inflammation (C‐reactive protein > 3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 [95% CI 1.12, 1.78] and 0.68 [95% CI 0.42, 1.11]). Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early‐onset type 2 DM. Conclusions: We found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early‐onset type 2 DM need clinical awareness and support.

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Despite an intensive focus on type 2 diabetes in general practice in Denmark, many patients are not treated optimally, nor do they follow recommendations for a healthy lifestyle.
“Despite an intensive focus on T2D in general practice in Denmark, many patients are not treated optimally, nor do they follow recommendations for a healthy lifestyle [6].”
From Long-term Weight Loss in a Primary Care-Anchored eHealth Lifestyle Coaching Program: Randomized Controlled Trial (2022) · cites this paper as [6]

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Authors: Bo, A., Thomsen, R. W., Nielsen, J. S., Nicolaisen, S. K., Beck‐Nielsen, H., Rungby, J., Sørensen, H. T., Hansen, T. K., Søndergaard, J., Friborg, S., Lauritzen, T., & Maindal, H. T.
Affiliations: Aarhus University (DK)
Aarhus University Hospital (DK)
Odense University Hospital (DK)
University of Southern Denmark (DK)
Corresponding author: Bo, A.
ORCID: Bo, A.
Thomsen, R.W.
Nielsen, J.S.
Nicolaisen, S.K.
Beck‐Nielsen, H.
Rungby, J.
Sørensen, H.T.
Hansen, T.K.
Søndergaard, J.
Lauritzen, T.
Maindal, H.T.
Venue: Diabetes/Metabolism Research and Reviews
Publisher: Wiley
Published: 2017-12-21
Volume: 34
Issue: 3
ISSN: 1520-7552 (ISSN-L)
1520-7560
DOI: 10.1002/dmrr.2968
OpenAlex: W2769678239
Cited by: 62
References: 32
Citations by year: 2026: 9 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4
FWCI: 2.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes/Metabolism Research and Reviews (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, other-oa)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Scopus (Elsevier) (submittedVersion)
Funders: Aarhus Universitet
Riisfort Fonden
Sundhedsstyrelsen
Styrelsen for Forskning og Innovation (09‐067009, 09‐075724)
Novo Nordisk UK Research Foundation
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: early-onset type 2 diabetes, age at diagnosis, diabetes risk factors, HbA1c, glycemic control, morbid obesity, dyslipidemia, low-grade inflammation, C-reactive protein, smoking, physical activity, diabetes complications
MeSH terms: Age Factors, Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Risk Factors, Body Mass Index, Age of Onset

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Early‐onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

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