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Eye regeneration at the molecular age
Open accessAbstract
Eye tissues such as the lens and the retina possess remarkable regenerative abilities. In amphibians, a complete lens can be regenerated after lentectomy. The process is a classic example of transdifferentiation of one cell type to another. Likewise, retina can be regenerated, but the strategy used to replace the damaged retina differs, depending on the animal system and the age of the animal. Retina can be regenerated by transdifferentiation or by the use of stem cells. In this review, we present a synthesis on the regenerative capacity of eye tissues in different animals with emphasis on the strategy and the molecules involved. In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances. Developmental Dynamics 226:211–224, 2003. © 2003 Wiley‐Liss, Inc.
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Cited by
Bridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
Merrell, A. J., & Stanger, B. Z. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.24 · Cited by 369
Bharti, K., Nguyen, M. T., Skuntz, S., Bertuzzi, S., & Arnheiter, H. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00318.x · Cited by 237
Susaki, K., & Chiba, C. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2007.00407.x · Cited by 48
Metadata
- Authors
- Rio‐Tsonis, K. D., & Tsonis, P. A.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2003-01-22
- Volume
- 226
- Issue
- 2
- Pages
- 211-224
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2092927664
- Cited by
- 178
- References
- 0
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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