The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
Open accessAbstract
Specific regions of the embryonic heart tube differentiate into atrial and ventricular chamber myocardium, whereas the inflow tract, atrioventricular canal, inner curvatures, and outflow tract do not. These regions express Tbx2, a transcriptional repressor. Here, we tested its role in chamber formation. The temporal and spatial pattern of Tbx2 mRNA and protein expression in mouse hearts was found to be complementary to that of chamber myocardium‐specific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human. In vitro, Tbx2 repressed the activity of regulatory fragments of Cx40, Cx43, and Nppa. Hearts of transgenic embryos that expressed Tbx2 in the prechamber myocardium completely failed to form chambers and to express the chamber myocardium‐specific genes Nppa, Cx40, and Chisel, whereas other cardiac genes were normally expressed. These findings provide the first evidence that Tbx2 is a determinant in the local repression of chamber‐specific gene expression and chamber differentiation. Developmental Dynamics 229:763–770, 2004. © 2004 Wiley‐Liss, Inc.
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Jacobs, J. J. L., Keblusek, P., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P. M., van Welsem, T., van de Vijver, M. J., Koh, E. Y., Daley, G. Q., et al. (2000) · Nature Genetics · doi:10.1038/81583 · Cited by 368
Lingbeek, M. E., Jacobs, J. J. L., & van Lohuizen, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200403200 · Cited by 160
Coll, M., Seidman, J. G., & Müller, C. W. (2002) · Structure · doi:10.1016/s0969-2126(02)00722-0 · Cited by 121
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Self-citationThe transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
HOOGAARS, W. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.030 · Cited by 339
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Zhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228
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Metadata
- Authors
- Christoffels, V. M., Hoogaars, W. M. H., Tessari, A., Clout, D. E. W., Moorman, A. F. M., & Campione, M.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2004-02-25
- Volume
- 229
- Issue
- 4
- Pages
- 763-770
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2130207795
- Cited by
- 272
- References
- 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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