Connexins: Key Mediators of Endocrine Function

Rho GTPases in cell biology

Etienne‐Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,796 · see citing works

Geometric Control of Cell Life and Death

Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,628 · see citing works

Physiology of Local Renin-Angiotensin Systems

Paul, M., Poyan Mehr, A., & Kreutz, R. (2006) · Physiological Reviews · doi:10.1152/physrev.00036.2005 · Cited by 1,739 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Islet cell failure in type 2 diabetes

Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690 · see citing works

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Culver, K. W., Ram, Z., Walbridge, S., Ishii, H., Oldfield, E. H., & Blaese, R. M. (1992) · Science · doi:10.1126/science.1317968 · Cited by 1,506 · see citing works

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

Lumelsky, N. L., Blondel, O., Laeng, P., Velasco, I., Ravin, R., & McKay, R. D. G. (2001) · Science · doi:10.1126/science.1058866 · Cited by 1,453 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Microfossils of the early Archean apex chert: New evidence of the antiquity of life

Schopf, J. W. (1993) · Science · doi:10.1126/science.260.5108.640 · Cited by 1,363 · see citing works

Cardiac Malformation in Neonatal Mice Lacking Connexin43

Reaume, A. G., Sousa, P. A. D., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,243 · see citing works

Cellular Heterogeneity: Do Differences Make a Difference?

Altschuler, S. J., & Wu, L. F. (2010) · Cell · doi:10.1016/j.cell.2010.04.033 · Cited by 1,214 · see citing works

Evolvability

Kirschner, M., & Gerhart, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8420 · Cited by 1,129 · see citing works

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

Chong, J. A., Tapia-Ramı́rez, J., Kim, S. S. Y., Toledo‐Aral, J. J., Zheng, Y., Boutros, M., Altshuller, Y. M., Frohman, M. A., Kraner, S. D., & Mandel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90298-8 · Cited by 1,089 · see citing works

The Neuron-Restrictive Silencer Factor (NRSF): A Coordinate Repressor of Multiple Neuron-Specific Genes

Schoenherr, C. J., & Anderson, D. J. (1995) · Science · doi:10.1126/science.7871435 · Cited by 1,088 · see citing works

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

Bruneau, B. G., Nemer, G. M., Schmitt, J. P., Charron, F., Robitaille, L., Caron, S., Conner, D. A., Gessler, M., Nemer, M. J., Seidman, C. E., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00493-7 · Cited by 1,048 · see citing works

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

Eizirik, D. L., Colli, M. L., & Ortis, F. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.21 · Cited by 1,011 · see citing works

Gap junctions and the connexin protein family

Söhl, G. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.013 · Cited by 986 · see citing works

Multicolor and Electron Microscopic Imaging of Connexin Trafficking

Gaietta, G. M., Deerinck, T. J., Adams, S., Bouwer, J. C., Tour, O., Laird, D. W., Sosinsky, G. E., Tsien, R. Y., & Ellisman, M. H. (2002) · Science · doi:10.1126/science.1068793 · Cited by 909 · see citing works

Mechanisms regulating renin release

Davis, J. O., & Freeman, R. H. (1976) · Physiological Reviews · doi:10.1152/physrev.1976.56.1.1 · Cited by 882 · see citing works

Regulation of insulin release by calcium.

Wollheim, C. B., & Sharp, G. W. (1981) · Physiological Reviews · doi:10.1152/physrev.1981.61.4.914 · Cited by 849 · see citing works

A molecular basis for bidirectional communication between the immune and neuroendocrine systems.

Blalock, J. E. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.1.1 · Cited by 847 · see citing works

Electrical Coupling and Neuronal Synchronization in the Mammalian Brain

Bennett, M. V. L., & Zukin, R. S. (2004) · Neuron · doi:10.1016/s0896-6273(04)00043-1 · Cited by 819 · see citing works

Emerging issues of connexin channels: biophysics fills the gap

Harris, A. L. (2001) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583501003705 · Cited by 800 · see citing works

Life cycle of connexins in health and disease

Laird, D. W. (2006) · Biochemical Journal · doi:10.1042/bj20051922 · Cited by 794 · see citing works

Pannexins, a family of gap junction proteins expressed in brain

Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 776 · see citing works

Female infertility in mice lacking connexin 37

Simon, A. M., Goodenough, D. A., Li, E., & Paul, D. L. (1997) · Nature · doi:10.1038/385525a0 · Cited by 732 · see citing works

Beyond the gap: functions of unpaired connexon channels

Goodenough, D. A., & Paul, D. L. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1072 · Cited by 729 · see citing works

Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques.

Musil, L. S., & Goodenough, D. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1357 · Cited by 706 · see citing works

Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release

Ye, Z., Wyeth, M. S., Tekkök, S. B., & Ransom, B. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03588.2003 · Cited by 706 · see citing works

Shape-Dependent Control of Cell Growth, Differentiation, and Apoptosis: Switching between Attractors in Cell Regulatory Networks

Huang, S., & Ingber, D. E. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5044 · Cited by 606 · see citing works

Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.

Paul, D. L., Ebihara, L., TAKEMOTO, L. J., Swenson, K. I., & Goodenough, D. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.4.1077 · Cited by 606 · see citing works

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

Sáez, J. C., Connor, J. A., Spray, D. C., & Bennett, M. V. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2708 · Cited by 595 · see citing works

Gap junction adhesion is necessary for radial migration in the neocortex

Elias, L., Wang, D. D., & Kriegstein, A. R. (2007) · Nature · doi:10.1038/nature06063 · Cited by 587 · see citing works

Expression and functions of neuronal gap junctions

Söhl, G., Maxeiner, S., & Willecke, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1627 · Cited by 578 · see citing works

Ischemia Opens Neuronal Gap Junction Hemichannels

Thompson, R. J., Zhou, N., & MacVicar, B. A. (2006) · Science · doi:10.1126/science.1126241 · Cited by 560 · see citing works

Connexin43 phosphorylation: structural changes and biological effects

Solan, J. L., & Lampe, P. D. (2009) · Biochemical Journal · doi:10.1042/bj20082319 · Cited by 556 · see citing works

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

Contreras, J. E., Sánchez, H. A., Eugenín, E. A., Speidel, D., Theis, M., Willecke, K., Bukauskas, F. F., Bennett, M. V. L., & Sáez, J. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012589799 · Cited by 543 · see citing works

Impaired Pulsatile Secretion of Insulin in Relatives of Patients with Non-Insulin-Dependent Diabetes

O'Rahilly, S., Turner, R. C., & Matthews, D. R. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181902 · Cited by 540 · see citing works

The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds

Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G. A., Pereira, E., Chaudhari, N., & Roper, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611280104 · Cited by 533 · see citing works

Adaptation of Islets of Langerhans to Pregnancy: β-Cell Growth, Enhanced Insulin Secretion and the Role of Lactogenic Hormones

Sorenson, R., & Brelje, T. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979040 · Cited by 531 · see citing works

Connexin 43 Hemichannels Are Permeable to ATP

Kang, J., Kang, N., Lovatt, D., Torres, A., Zhao, Z., Lin, J. H.-C., & Nedergaard, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5048-07.2008 · Cited by 507 · see citing works

Gap junctions in the brain: where, what type, how many and why?

Dermietzel, R., & Spray, D. C. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90151-b · Cited by 501 · see citing works

The Origin and Evolution of Mammals

Kemp, T. S. (2004) · Oxford University Press eBooks · doi:10.1093/oso/9780198507604.001.0001 · Cited by 497 · see citing works

Transmission of hormonal stimulation by cell-to-cell communication

Lawrence, T. S., Beers, W. H., & Gilula, N. B. (1978) · Nature · doi:10.1038/272501a0 · Cited by 489 · see citing works

Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions

Shaw, R. M., Fay, A. J., Puthenveedu, M. A., von Zastrow, M., Jan, Y. N., & Jan, L. Y. (2007) · Cell · doi:10.1016/j.cell.2006.12.037 · Cited by 487 · see citing works

Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia

Retamal, M. A., Froger, N., Palacios‐Prado, N., Ezan, P., Sáez, P. J., Sáez, J. C., & Giaume, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2042-07.2007 · Cited by 476 · see citing works

Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons

Condorelli, D. F., Parenti, R., Spinella, F., Salinaro, A. T., Belluardo, N., Cardile, V., & Cicirata, F. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00163.x · Cited by 473 · see citing works

Ion Channels and Disease

(2000) · Elsevier eBooks · doi:10.1016/b978-0-12-065310-2.x5000-0 · Cited by 472 · see citing works

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes

Bruzzone, R., Barbe, M. T., Jakob, N. J., & Monyer, H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02947.x · Cited by 463 · see citing works

COMMENTARY: Role of connexin genes in growth control

Yamasaki, H., & Naus, C. C. G. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1199 · Cited by 458 · see citing works

Axo-Axonal Coupling

Schmitz, D., Schuchmann, S., Fisahn, A., Draguhn, A., Buhl, E. H., Petrasch‐Parwez, E., Dermietzel, R., Heinemann, U., & Traub, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00410-x · Cited by 456 · see citing works

The origins of multicellularity

Bonner, J. T. (1998) · Integrative Biology Issues News and Reviews · doi:10.1002/(sici)1520-6602(1998)1:1 · Cited by 455 · see citing works

Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia

Bergfeld, G. R., & Forrester, T. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.1.40 · Cited by 453 · see citing works

Gating and regulation of connexin 43 (Cx43) hemichannels

Contreras, J. E., Sáez, J. C., Bukauskas, F. F., & Bennett, M. V. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434298100 · Cited by 438 · see citing works

Cells, Embryos and Evolution

Gerhart, J. C., & Kirschner, M. W. (1997) · Cited by 437 · see citing works

Electrical synapses between Gaba-Releasing interneurons

Galarreta, M., & Hestrin, S. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077566 · Cited by 434 · see citing works

Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.056 · Cited by 434 · see citing works

In Vitro Evidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSV tk Retroviral Gene Therapy

Bi, W., Parysek, L. M., Warnick, R. E., & Stambrook, P. J. (1993) · Human Gene Therapy · doi:10.1089/hum.1993.4.6-725 · Cited by 416 · see citing works

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K., & Yamasaki, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1831 · Cited by 411 · see citing works

Connexin-based gap junction hemichannels: Gating mechanisms

Sáez, J. C., Retamal, M. A., Basilio, D., Bukauskas, F. F., & Bennett, M. V. L. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.01.014 · Cited by 411 · see citing works

The gap junction cellular internet: connexin hemichannels enter the signalling limelight

Evans, W. H., Vuyst, E. D., & Leybaert, L. (2006) · Biochemical Journal · doi:10.1042/bj20060175 · Cited by 409 · see citing works

The theory of facilitated variation

Gerhart, J. C., & Kirschner, M. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701035104 · Cited by 404 · see citing works

GENETIC DISEASES AND GENE KNOCKOUTS REVEAL DIVERSE CONNEXIN FUNCTIONS

White, T. W., & Paul, D. L. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.283 · Cited by 398 · see citing works

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

Steinberg, T. H., Newman, A. S., Swanson, J. A., & Silverstein, S. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47497-2 · Cited by 397 · see citing works

Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice

Kirchhoff, S., Nelles, E., Hagendorff, A., Krüger, O., Traub, O., & Willecke, K. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70114-9 · Cited by 391 · see citing works

Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.

Nelles, E., Bützler, C., Jung, D., Temme, A., Gabriel, H., Dahl, U., Traub, O., Stümpel, F. T., Jungermann, K. A., Zielasek, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9565 · Cited by 387 · see citing works

Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block

Simon, A. M., Goodenough, D. A., & Paul, D. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70113-7 · Cited by 385 · see citing works

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

Hoogaars, W. M., Tessari, A., Moorman, A., de Boer, P. D., Hagoort, J., Soufan, A., Campione, M., & Christoffels, V. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.030 · Cited by 378 · see citing works

Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.

Sanderson, M. J., Charles, A. C., & Dirksen, E. R. (1990) · Cell Regulation · doi:10.1091/mbc.1.8.585 · Cited by 375 · see citing works

Update on connexins and gap junctions in neurons and glia in the mammalian nervous system

Nagy, J. I., Dudek, F. E., & Rash, J. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.005 · Cited by 375 · see citing works

Defective vascular development in connexin 45-deficient mice

Krüger, O., Plum, A., Kim, J.-S., Winterhager, E., Maxeiner, S., Hallas, G., Kirchhoff, S., Traub, O., Lamers, W. H., & Willecke, K. (2000) · Development · doi:10.1242/dev.127.19.4179 · Cited by 364 · see citing works

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

Kulkarni, R. N., Holzenberger, M., Shih, D. Q., Özcan, U., Stoffel, M., Magnuson, M. A., & Kahn, C. R. (2002) · Nature Genetics · doi:10.1038/ng872 · Cited by 363 · see citing works

Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release

Ravier, M. A., Güldenagel, M., Charollais, A., Gjinovci, A., Caille, D., Söhl, G., Wollheim, C. B., Willecke, K., Henquin, J.-C., & Meda, P. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1798 · Cited by 360 · see citing works

The preparation of, and studies on, free cell suspensions from mouse pancreatic islets

Lernmark, Å. (1974) · Diabetologia · doi:10.1007/bf01221634 · Cited by 360 · see citing works

Interplay of Nutrients and Hormones in the Regulation of Insulin Release*

PIPELEERS, D. G., Schuit, F. C., Veld, P. I. '., Maes, E., Hooghe-Peters, E. L., Winkel, M. V. D., & Gepts, W. (1985) · Endocrinology · doi:10.1210/endo-117-3-824 · Cited by 358 · see citing works

ATP Release From Activated Neutrophils Occurs via Connexin 43 and Modulates Adenosine-Dependent Endothelial Cell Function

Eltzschig, H. K., Eckle, T. D. L. G., Mager, A., Küper, N., Karcher, C., Weissmüller, T., Boengler, K., Schulz, R., Robson, S. C., & Colgan, S. P. (2006) · Circulation Research · doi:10.1161/01.res.0000250174.31269.70 · Cited by 354 · see citing works

Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins

Garfield, R. E., Kannan, M., & Daniel, E. E. (1980) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1980.238.3.c81 · Cited by 353 · see citing works

Gap junctions and ovarian folliculogenesis

Kidder, G. M., & Mhawi, A. (2002) · Reproduction · doi:10.1530/rep.0.1230613 · Cited by 347 · see citing works

Impaired conduction of vasodilation along arterioles in connexin40-deficient mice

de Wit, C., Roos, F., Bolz, S.-S., Kirchhoff, S., Krüger, O., Willecke, K., & Pohl, U. (2000) · Circulation Research · doi:10.1161/01.res.86.6.649 · Cited by 338 · see citing works

Gap Junctions: Their Presence and Necessity in Myometrium During Parturition

Garfield, R. E., Sims, S., & Daniel, E. E. (1977) · Science · doi:10.1126/science.929182 · Cited by 329 · see citing works

Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells.

Li, H., Liu, T. F., Lazrak, A., Peracchia, C., Goldberg, G. S., Lampe, P. D., & Johnson, R. G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1019 · Cited by 329 · see citing works

Metabolic co-operation between biochemically marked mammalian cells in tissue culture

Subak-Sharpe, H., Bürk, R. R., & Pitts, J. D. (1969) · Journal of Cell Science · doi:10.1242/jcs.4.2.353 · Cited by 328 · see citing works

Functional connexin “hemichannels”: A critical appraisal

Spray, D. C., Ye, Z., & Ransom, B. R. (2006) · Glia · doi:10.1002/glia.20429 · Cited by 319 · see citing works

Regulation of connexin biosynthesis, assembly, gap junction formation, and removal

Segretain, D., & Falk, M. M. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.01.007 · Cited by 318 · see citing works

Cells into Organs: The Forces That Shape the Embryo

Trinkaus, J. P. (1970) · DigitalGeorgetown (Georgetown University Library) · Cited by 315 · see citing works

Uterine contraction and physiological mechanisms of modulation

Wray, S. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.1.c1 · Cited by 315 · see citing works

The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development

Rokas, A. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091513 · Cited by 312 · see citing works

EphA-Ephrin-A-Mediated β Cell Communication Regulates Insulin Secretion from Pancreatic Islets

Konstantinova, I., Nikolova, G. V., Ohara‐Imaizumi, M., Meda, P., Kučera, T., Zarbalis, K. S., Wurst, W., Nagamatsu, S., & Lammert, E. (2007) · Cell · doi:10.1016/j.cell.2007.02.044 · Cited by 310 · see citing works

Intercellular calcium signaling via gap junctions in glioma cells.

Charles, A. C., Naus, C. C. G., Zhu, D., Kidder, G. M., Dirksen, E. R., & Sanderson, M. J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.1.195 · Cited by 309 · see citing works

Structure-activity relations of the cardiac gap junction channel

Spray, D. C., & Burt, J. M. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.2.c195 · Cited by 309 · see citing works

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

Schuit, F. C., In't Veld, P. A., & Pipeleers, D. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3865 · Cited by 308 · see citing works

Selective transfer of endogenous metabolites through gap junctions composed of different connexins

Goldberg, G. S., Lampe, P. D., & Nicholson, B. J. (1999) · Nature Cell Biology · doi:10.1038/15693 · Cited by 308 · see citing works

Physiological Role of Gap-Junctional Hemichannels

Quist, A. P., Rhee, S. K., Lin, H., & Lal, R. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.1063 · Cited by 304 · see citing works

Connexin phosphorylation as a regulatory event linked to gap junction channel assembly

Solan, J. L., & Lampe, P. D. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.09.013 · Cited by 296 · see citing works

T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers

Christoffels, V., Hoogaars, W. M., Tessari, A., Clout, D., Moorman, A., & Campione, M. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10487 · Cited by 295 · see citing works

Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43

Rash, J. E., Staines, W. A., Yasumura, T., Patel, D., Furman, C. S., Stelmack, G. L., & Nagy, J. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7573 · Cited by 293 · see citing works

Gap Junctions in the Control of Vascular Function

Figueroa, X. F., & Duling, B. R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2117 · Cited by 293 · see citing works

Functional Properties of Channels Formed by the Neuronal Gap Junction Protein Connexin36

Srinivas, M., Rozental, R., Kojima, T., Dermietzel, R., Mehler, M., Condorelli, D. F., Kessler, J. A., & Spray, D. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09848.1999 · Cited by 290 · see citing works

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

Stennard, F. A., Costa, M. W., Elliott, D. A., Rankin, S. A., Haast, S. J. P., Lai, D., McDonald, L., Niederreither, K., Dollé, P., Bruneau, B. G., et al. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00385-3 · Cited by 289 · see citing works

Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels

Orellana, J. A., Shoji, K. F., Abudara, V., Ezan, P., Amigou, E., Sáez, P. J., Jiang, J. X., Naus, C. C. G., Sáez, J. C., & Giaume, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6417-10.2011 · Cited by 286 · see citing works

Hemi‐gap‐junction channels in solitary horizontal cells of the catfish retina.

DeVries, S. H., & Schwartz, E. A. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp018920 · Cited by 279 · see citing works

Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

Roith, D. L., Shiloach, J., Roth, J., & Lesniak, M. A. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.10.6184 · Cited by 279 · see citing works

Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

Swenson, K. I., Piwnica-Worms, H. M., McNamee, H., & Paul, D. L. (1990) · Cell Regulation · doi:10.1091/mbc.1.13.989 · Cited by 278 · see citing works

A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill

Groenewegen, W. A., Firouzi, M., Bezzina, C. R., Vliex, S., van Langen, I. M., Sandkuijl, L. A., Smits, J. P. P., Hulsbeek, M. M. F., Rook, M. B., Jongsma, H. J., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000050585.07097.d7 · Cited by 277 · see citing works

Pannexin1 Channels Contain a Glycosylation Site That Targets the Hexamer to the Plasma Membrane

Boassa, D., Ambrosi, C., Qiu, F., Dahl, G., Gaietta, G. M., & Sosinsky, G. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702422200 · Cited by 276 · see citing works

Gap Junctions in Vascular Tissues

Christ, G. J., Spray, D. C., El-Sabban, M. E., Moore, L. K., & Brink, P. R. (1996) · Circulation Research · doi:10.1161/01.res.79.4.631 · Cited by 273 · see citing works

Renin Cells Are Precursors for Multiple Cell Types that Switch to the Renin Phenotype When Homeostasis Is Threatened

Sequeira-Lόpez, M. L. S., Pentz, E. S., Nomasa, T., Smithies, O., & Gómez, R. A. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00134-0 · Cited by 268 · see citing works

Visual Transmission Deficits in Mice with Targeted Disruption of the Gap Junction Gene Connexin36

Güldenagel, M., Ammermüller, J., Feigenspan, A., Teubner, B., Degen, J., Söhl, G., Willecke, K., & Weiler, R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06036.2001 · Cited by 267 · see citing works

Connexin-43 Hemichannels Opened by Metabolic Inhibition

John, S., Kondo, R. P., Wang, S., Goldhaber, J. I., & Weiss, J. N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.236 · Cited by 265 · see citing works

GJA1mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype

Paznekas, W. A., Karczeski, B. A., Vermeer, S., Lowry, R. B., Delatycki, M. B., Faivre, L. O., Koivisto, P. A., Maldergem, L. V., Boyadjiev, S. A., Bodurtha, J. N., et al. (2009) · Human Mutation · doi:10.1002/humu.20958 · Cited by 265 · see citing works

Selectivity of Connexin-Specific Gap Junctions Does Not Correlate With Channel Conductance

Veenstra, R. D., Wang, H.-Z., Beblo, D. A., Chilton, M. G., Harris, A. L., Beyer, E. C., & Brink, P. R. (1995) · Circulation Research · doi:10.1161/01.res.77.6.1156 · Cited by 262 · see citing works

Physiology of Kidney Renin

Castrop, H., Höcherl, K., Kurtz, A., Schweda, F., Todorov, V., & Wagner, C. (2010) · Physiological Reviews · doi:10.1152/physrev.00011.2009 · Cited by 260 · see citing works

Electrophysiology of the pancreas.

Petersen, O. H., & Findlay, I. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.3.1054 · Cited by 259 · see citing works

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

Aa, E., Saavedra, A., Zhang, H., Kucharczuk, J. C., Dc, S., Fishman, G. I., Km, A., Kaiser, L. R., & Albelda, S. (1996) · PubMed · Cited by 259 · see citing works

Innexins: members of an evolutionarily conserved family of gap-junction proteins

Phelan, P. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.10.004 · Cited by 258 · see citing works

Unique and shared functions of different connexins in mice

Plum, A., Hallas, G., Magin, T. M., Dombrowski, F., Hagendorff, A., Schumacher, B. M., Wolpert, C., Kim, J.-S., Lamers, W. H., Evert, M., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00690-4 · Cited by 255 · see citing works

Modulation of gap junction transcript and protein expression during pregnancy in the rat.

Risek, B., Guthrie, S., Kumar, N. M., & Gilula, N. B. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.2.269 · Cited by 255 · see citing works

Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells

Salomon, D., & Meda, P. (1986) · Experimental Cell Research · doi:10.1016/0014-4827(86)90354-x · Cited by 252 · see citing works

Ancient origin of the integrin-mediated adhesion and signaling machinery

Sebé-Pedrós, A., Roger, A. J., Lang, B. F., King, N., & Ruiz‐Trillo, I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002257107 · Cited by 250 · see citing works

Connexin Family Members Target to Lipid Raft Domains and Interact with Caveolin-1

Schubert, A.-L., Schubert, W., Spray, D. C., & Lisanti, M. P. (2002) · Biochemistry · doi:10.1021/bi0121656 · Cited by 249 · see citing works

Rhythmicity without Synchrony in the Electrically Uncoupled Inferior Olive

Long, M. A., Deans, M. R., Paul, D. L., & Connors, B. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10898.2002 · Cited by 249 · see citing works

Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice

Liao, Y., Day, K. H., Damon, D. N., & Duling, B. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171305298 · Cited by 246 · see citing works

Contribution of connexins to the function of the vascular wall

Haefliger, J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.015 · Cited by 242 · see citing works

Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

Mori, Y., Otabe, S., Christian Dina, C., Yasuda, K., Populaire, C., Lecœur, C., Vatin, V., Durand, E., Hara, K., Okada, T., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1247 · Cited by 242 · see citing works

Size and selectivity of gap junction channels formed from different connexins

Veenstra, R. D. (1996) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110109 · Cited by 240 · see citing works

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

Benninger, R. K. P., Zhang, M., Head, W. S., Satin, L. S., & Piston, D. W. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.140863 · Cited by 240 · see citing works

The Premetazoan Ancestry of Cadherins

Sigg, M. A., & King, N. (2008) · Science · doi:10.1126/science.1151084 · Cited by 239 · see citing works

Cooperation and conflict in the evolution of multicellularity

Michod, R. E., & Roze, D. (2001) · Heredity · doi:10.1046/j.1365-2540.2001.00808.x · Cited by 235 · see citing works

Glucose-induced insulin release depends on functional cooperation between islet cells.

PIPELEERS, D. G., Veld, P. I. '., Maes, E., & Winkel, M. V. D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7322 · Cited by 234 · see citing works

A receptor tyrosine kinase from choanoflagellates: Molecular insights into early animal evolution

King, N., & Carroll, S. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261477698 · Cited by 234 · see citing works

Gap Junctions between Cells Expressing Connexin 43 or 32 Show Inverse Permselectivity to Adenosine and ATP

Goldberg, G. S., Moreno, A. P., & Lampe, P. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109797200 · Cited by 233 · see citing works

Connexin and pannexin mediated cell–cell communication

Scemes, E., Suadicani, S. O., Dahl, G., & Spray, D. C. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000069 · Cited by 233 · see citing works

Non‐syndromic, autosomal‐recessive deafness

Petersen, M., & Willems, P. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00613.x · Cited by 231 · see citing works

Structural diversity of gap junctions. A review

Larsen, W. J. (1977) · Tissue and Cell · doi:10.1016/0040-8166(77)90001-5 · Cited by 230 · see citing works

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

Kutlu, B., Cardozo, A. K., Darville, M. I., Kruhøffer, M., Magnusson, N. E., Orntoft, T. F., & Eizirik, D. L. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2701 · Cited by 230 · see citing works

The Evolutionary Origins of Hormones, Neurotransmitters, and Other Extracellular Chemical Messengers

Bleich, H. L., Moore, M. J., Roth, J., LeRoith, D., Shiloach, J., Rosenzweig, J. L., Lesniak, M. A., & Havránková, J. (1982) · New England Journal of Medicine · doi:10.1056/nejm198203043060907 · Cited by 229 · see citing works

Novel therapies for scar reduction and regenerative healing of skin wounds

Rhett, J. M., Ghatnekar, G. S., Palatinus, J. A., O’Quinn, M. P., Yost, M. J., & Gourdie, R. G. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2007.12.007 · Cited by 227 · see citing works

Innexins get into the gap

Phelan, P., & Starich, T. A. (2001) · BioEssays · doi:10.1002/bies.1057 · Cited by 226 · see citing works

Gap junctional communication in the post-implantation mouse embryo

Lo, C. W., & Gilula, N. B. (1979) · Cell · doi:10.1016/0092-8674(79)90060-6 · Cited by 225 · see citing works

The crystalline lens. A system networked by gap junctional intercellular communication

Goodenough, D. A. (1992) · Seminars in Cell Biology · doi:10.1016/s1043-4682(10)80007-8 · Cited by 224 · see citing works

Gap junctional complexes: From partners to functions

Hervé, J., Bourmeyster, N., Sarrouilhe, D., & Duffy, H. S. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2007.03.010 · Cited by 223 · see citing works

Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions

Xu, X. Y., Li, W., Huang, G., Meyer, R., Chen, T., Luo, Y., Thomas, M., Radice, G. L., & Lo, C. W. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105047 · Cited by 223 · see citing works

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

Orellana, J. A., Sáez, P. J., Shoji, K. F., Schalper, K. A., Palacios‐Prado, N., Velarde, V., Giaume, C., Bennett, M. V. L., & Sáez, J. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2130 · Cited by 222 · see citing works

Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate

Niessen, H., Harz, H., Bedner, P., Krämer, K., & Willecke, K. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.8.1365 · Cited by 219 · see citing works

Heterogeneity in Pancreatic β-cell Population

PIPELEERS, D. G. (1992) · Diabetes · doi:10.2337/diab.41.7.777 · Cited by 214 · see citing works

Quinine blocks specific gap junction channel subtypes

Srinivas, M., Hopperstad, M. G., & Spray, D. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191206198 · Cited by 212 · see citing works

Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly.

Lampe, P. D. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1895 · Cited by 212 · see citing works

Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies

Juszczak, G. R., & Swiergiel, A. H. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.014 · Cited by 211 · see citing works

Evolution of gap junction proteins – the pannexin alternative

Panchin, Y. V. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01547 · Cited by 210 · see citing works

Folliculostellate cell network: A route for long-distance communication in the anterior pituitary

Fauquier, T., Guérineau, N. C., McKinney, R. A., Bauer, K., & Mollard, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151339598 · Cited by 208 · see citing works

The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

Fick, J. R., Barker, F. G., Dazin, P. F., Westphale, E. M., Beyer, E. C., & Israel, M. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11071 · Cited by 206 · see citing works

Quantitative Subcellular Imaging of Glucose Metabolism within Intact Pancreatic Islets

Bennett, B. D., Jetton, T. L., Ying, G., Magnuson, M. A., & Piston, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3647 · Cited by 203 · see citing works

Connexin40 Is Essential for the Pressure Control of Renin Synthesis and Secretion

Wagner, C., de Wit, C., Kurtz, L., Grünberger, C., Kurtz, A., & Schweda, F. (2007) · Circulation Research · doi:10.1161/01.res.0000258856.19922.45 · Cited by 202 · see citing works

Differential expression of gap junction connexins in endocrine and exocrine glands

Meda, P., Pepper, M. S., Traub, O., Willecke, K., Gros, D. B., Beyer, E. C., Nicholson, B., Paul, D. L., & Orci, L. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404689 · Cited by 199 · see citing works

Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40

Simon, A. M., & McWhorter, A. R. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0826 · Cited by 197 · see citing works

Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells

Christ, G. J., Moreno, A. P., Melman, A., & Spray, D. C. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.2.c373 · Cited by 197 · see citing works

Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth

Mehta, P. P., Hotz‐Wagenblatt, A., Rose, B., Shalloway, D. I., & Loewenstein, W. R. (1991) · The Journal of Membrane Biology · doi:10.1007/bf01994355 · Cited by 196 · see citing works

Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

Hussain, M. J., Peakman, M., Gallati, H., Lo, S. S. S., Hawa, M. I., Viberti, G. C., Watkins, P., Leslie, R. D., & Vergani, D. (1996) · Diabetologia · doi:10.1007/bf00400414 · Cited by 196 · see citing works

A germline-specific gap junction protein required for survival of differentiating early germ cells

Tazuke, S. I., Schulz, C., Gilboa, L., Fogarty, M., Mahowald, A. P., Guichet, A., Ephrussi, A., Wood, C. G., Lehmann, R., & Fuller, M. T. (2002) · Development · doi:10.1242/dev.129.10.2529 · Cited by 193 · see citing works

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

Meier, J., Lin, J. C., Butler, A., Galasso, R., Martinez, D., & Butler, P. (2006) · Diabetologia · doi:10.1007/s00125-006-0308-2 · Cited by 192 · see citing works

Connexin45 (?6) expression delineates an extended conduction system in the embryonic and mature rodent heart

Coppen, S. R., Severs, N. J., & Gourdie, R. G. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)24:1/2 · Cited by 191 · see citing works

Metabolic Inhibition Activates a Non-selective Current Through Connexin Hemichannels in Isolated Ventricular Myocytes

Kondo, R. P., Wang, S., John, S., Weiss, J. N., & Goldhaber, J. I. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1220 · Cited by 190 · see citing works

Connexins, pannexins, innexins: novel roles of “hemi-channels”

Scemes, E., Spray, D. C., & Meda, P. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0591-5 · Cited by 190 · see citing works

Drebrin Is a Novel Connexin-43 Binding Partner that Links Gap Junctions to the Submembrane Cytoskeleton

Butkevich, E., Hülsmann, S., Wenzel, D., Shirao, T., Duden, R., & Majoul, I. V. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.063 · Cited by 190 · see citing works

Oscillatory control of insulin secretion

Tengholm, A., & Gylfe, E. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.009 · Cited by 188 · see citing works

Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene

Watanabe, M., Iwashita, M., Ishii, M., Kurachi, Y., Kawakami, A., Kondo, S., & Okada, N. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400757 · Cited by 186 · see citing works

The connexin43 gene is responsive to oestrogen

Yu, W., Dahl, G., & Werner, R. (1994) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1994.0018 · Cited by 185 · see citing works

Association of Human Connexin40 Gene Polymorphisms With Atrial Vulnerability as a Risk Factor for Idiopathic Atrial Fibrillation

Firouzi, M., Ramanna, H., Kok, B., Jongsma, H. J., Koeleman, B. P. C., Doevendans, P. A., Groenewegen, W. A., & Hauer, R. N. W. (2004) · Circulation Research · doi:10.1161/01.res.0000141134.64811.0a · Cited by 180 · see citing works

Pannexins and gap junction protein diversity

Shestopalov, V. I., & Panchin, Y. V. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7200-1 · Cited by 176 · see citing works

Expression of Connexin-43 and Connexin-26 in the Rat Myometrium during Pregnancy and Labor Is Differentially Regulated by Mechanical and Hormonal Signals*

Ou, C., Orsino, A., & Lye, S. J. (1997) · Endocrinology · doi:10.1210/endo.138.12.5624 · Cited by 176 · see citing works

Evidence for the participation of actin microfilaments and bristle coats in the internalization of gap junction membrane.

Larsen, W. J., Tung, H. N., Murray, S., & Swenson, C. A. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.3.576 · Cited by 175 · see citing works

Why Size Matters

Bonner, J. T. (2007) · Princeton University Press eBooks · doi:10.1515/9781400837557 · Cited by 173 · see citing works

Connexins: functions without junctions

Stout, C. E., Goodenough, D. A., & Paul, D. L. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.07.014 · Cited by 172 · see citing works

Pannexin: To gap or not to gap, is that a question?

Dahl, G., & Locovei, S. (2006) · IUBMB Life · doi:10.1080/15216540600794526 · Cited by 172 · see citing works

Electrophysiological evidence for coupling between β cells of pancreatic islets

Meissner, H. P. (1976) · Nature · doi:10.1038/262502a0 · Cited by 172 · see citing works

Population robustness arising from cellular heterogeneity

Paszek, P., Ryan, S., Ashall, L., Sillitoe, K., Harper, C. V., Spiller, D. G., Rand, D. A. J., & White, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913798107 · Cited by 172 · see citing works

Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells

Xu, X. Y., Francis, R. J. B., Wei, C. J., Linask, K. L., & Lo, C. W. (2006) · Development · doi:10.1242/dev.02543 · Cited by 169 · see citing works

Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process

Piehl, M., Lehmann, C., Gumpert, A. M., Denizot, J., Segretain, D., & Falk, M. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0487 · Cited by 168 · see citing works

Heterogeneity in glucose sensitivity among pancreatic beta‐cells is correlated to differences in glucose phosphorylation rather than glucose transport.

Heimberg, H., Vos, A. D., Vandercammen, A., SCHAFTINGEN, E. V., PIPELEERS, D. G., & Schuit, F. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05949.x · Cited by 167 · see citing works

Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells.

Bosco, D., Orci, L., & Meda, P. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90365-0 · Cited by 167 · see citing works

The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication

Azarnia, R., Reddy, S., Kmiecik, T. E., Shalloway, D. I., & Loewenstein, W. R. (1988) · Science · doi:10.1126/science.2447651 · Cited by 167 · see citing works

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Yamagata, K., Nammo, T., Moriwaki, M., Ihara, A., Iizuka, K., Yang, Q., Satoh, T., Li, M., Uenaka, R., Okita, K., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.1.114 · Cited by 167 · see citing works

Control mechanisms of the oscillations of insulin secretion in vitro and in vivo.

Gilon, P., Ravier, M., Jonas, J., & Henquin, J. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s144 · Cited by 166 · see citing works

Cx36-Mediated Coupling Reduces β-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics

Speier, S., Gjinovci, A., Charollais, A., Meda, P., & Rupnik, M. (2007) · Diabetes · doi:10.2337/db06-0232 · Cited by 166 · see citing works

Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43

Leithe, E., & Rivedal, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.00951 · Cited by 165 · see citing works

Ubiquitination and Down-regulation of Gap Junction Protein Connexin-43 in Response to 12-O-Tetradecanoylphorbol 13-Acetate Treatment

Leithe, E., & Rivedal, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402006200 · Cited by 164 · see citing works

Cx36 preferentially connects beta-cells within pancreatic islets.

Serre‐Beinier, V., Gurun, S. L., Belluardo, N., Salinaro, A. T., Charollais, A., Haefliger, J., Condorelli, D. F., & Meda, P. (2000) · Diabetes · doi:10.2337/diabetes.49.5.727 · Cited by 164 · see citing works

Connexin30 deficiency causes instrastrial fluid–blood barrier disruption within the cochlear stria vascularis

Cohen‐Salmon, M., Regnault, B., Cayet, N., Caille, D., Demuth, K., Hardelin, J., Janel, N., Meda, P., & Petit, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605108104 · Cited by 163 · see citing works

Gap-Junction Channels Dysfunction in Deafness and Hearing Loss

Martı́nez, A. D., Acuña, R. A., Figueroa, V. A., Maripillán, J., & Nicholson, B. J. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2138 · Cited by 163 · see citing works

Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels

Martin, P. E., Blundell, G. K., Ahmad, S., Errington, R. J., & Evans, W. H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.21.3845 · Cited by 163 · see citing works

Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential

Retamal, M. A., Schalper, K. A., Shoji, K. F., Bennett, M. V. L., & Sáez, J. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702456104 · Cited by 162 · see citing works

Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity.

Kiekens, R., Veld, P. I. '. '., Mahler, T., Schuit, F., van de Winkel, M., & Pipeleers, D. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115551 · Cited by 161 · see citing works

Silencing is golden: negative regulation in the control of neuronal gene transcription

Schoenherr, C. J., & Anderson, D. J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80060-3 · Cited by 160 · see citing works

Connexins are mechanosensitive

Li, B., Sachs, F., & Dahl, G. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00220.2004 · Cited by 159 · see citing works

Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion.

Mêda, P., Perrelet, A., & Orci, L. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.82.2.441 · Cited by 158 · see citing works

Calcium wave of tubuloglomerular feedback

Peti‐Peterdi, J. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00425.2005 · Cited by 157 · see citing works

Deformation of Network Connectivity in the Inferior Olive of Connexin 36-Deficient Mice Is Compensated by Morphological and Electrophysiological Changes at the Single Neuron Level

Zeeuw, C. I. D., Chorev, E., Devor, A., Manor, Y., van der Giessen, R. S., de Jeu, M. T. G., Hoogenraad, C. C., Bijman, J., Ruigrok, T. J. H., French, P. J., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04700.2003 · Cited by 156 · see citing works

Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications.

Sáez, J. C., Berthoud, V. M., Moreno, A. P., & Spray, D. C. (1993) · PubMed · Cited by 155 · see citing works

Rapid engineering of bacterial artificial chromosomes using oligonucleotides

Swaminathan, S., Ellis, H. M., Waters, L. S., Yu, D., Lee, E.-C., Court, D. L., & Sharan, S. K. (2000) · genesis · doi:10.1002/1526-968x(200101)29:1 · Cited by 154 · see citing works

Activity‐dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells.

Kiss, J. Z., Wang, C., Olive, S., Rougon, G. N., Lang, J., Baetens, D., Harry, D., & Pralong, W. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06862.x · Cited by 153 · see citing works

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works

Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells

Spéder, P., & Brand, A. H. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.05.021 · Cited by 160 · see citing works

Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

Esfandyari, S., Elkafas, H., Chugh, R. M., Park, H.-S., Navarro, A., & Al-Hendy, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042165 · Cited by 157 · see citing works

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

Benninger, R. K. P., & Piston, D. W. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.005 · Cited by 145 · see citing works

Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

Billaud, M., Lohman, A. W., Johnstone, S. R., Biwer, L. A., Mutchler, S. M., & Isakson, B. E. (2014) · Pharmacological Reviews · doi:10.1124/pr.112.007351 · Cited by 110 · see citing works

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

Tirosh, A., Tuncman, G., Calay, E. S., RATHAUS, M., Ron, I., Tirosh, A., Yalçın, A., Lee, Y. G., Livne, R., Ron, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.009 · Cited by 104 · see citing works

Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier

Branca, J. J. V., Maresca, M., Morucci, G., Mello, T., Becatti, M., Pazzagli, L., Colzi, I., Gonnelli, C., Carrino, D., Paternostro, F., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236010 · Cited by 96 · see citing works

Extracellular Nucleotides and P2 Receptors in Renal Function

Vallon, V., Unwin, R. J., Inscho, E. W., Leipziger, J., & Kishore, B. K. (2019) · Physiological Reviews · doi:10.1152/physrev.00038.2018 · Cited by 92 · see citing works

New insights into the role of connexins in pancreatic islet function and diabetes

Farnsworth, N. L., & Benninger, R. K. P. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.035 · Cited by 86 · see citing works

Regulation of Blood–Testis Barrier (BTB) Dynamics during Spermatogenesis via the “Yin” and “Yang” Effects of Mammalian Target of Rapamycin Complex 1 (mTORC1) and mTORC2

Mok, K., Mruk, D. D., & Cheng, C. Y. (2013) · International review of cytology · doi:10.1016/b978-0-12-407704-1.00006-3 · Cited by 82 · see citing works

Mechanisms of Connexin-Related Lymphedema

Castorena‐Gonzalez, J. A., Zawieja, S. D., Li, M., Srinivasan, R. S., Simon, A. M., de Wit, C., de la Torre, R. A., Martinez‐Lemus, L. A., Hennig, G. W., & Davis, M. J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312576 · Cited by 78 · see citing works

Is pannexin the pore associated with the P2X7 receptor?

Alberto, A. V. P., Faria, R. X., Couto, C. G. C., Ferreira, L. G. B., Souza, C. A. M., Teixeira, P. C. N., Fróes, M. M., & Alves, L. A. (2013) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-013-0868-x · Cited by 78 · see citing works

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice

Carvalho, C. P. D. F., de Oliveira, R. B., Britan, A., Santos-Silva, J. C., Boschero, A. C., Meda, P., & Collares‐Buzato, C. B. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00489.2011 · Cited by 77 · see citing works

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

Johnson, K. E., Mitra, S., Katoch, P., Kelsey, L. S., Johnson, K. R., & Mehta, P. P. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-07-0537 · Cited by 70 · see citing works

Connexins protect mouse pancreatic β cells against apoptosis

Klee, P., Allagnat, F., Pontes, H., Cederroth, M., Charollais, A., Caille, D., Britan, A., Haefliger, J., & Meda, P. (2011) · Journal of Clinical Investigation · doi:10.1172/jci40509 · Cited by 67 · see citing works

The Role of cAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling

Stožer, A., Leitgeb, E. P., Pohorec, V., Dolenšek, J., Bombek, L. K., Gosak, M., & Klemen, M. S. (2021) · Cells · doi:10.3390/cells10071658 · Cited by 64 · see citing works

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

Rutter, G., & Hodson, D. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1755-4 · Cited by 65 · see citing works

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Price, G. W., Chadjichristos, C. E., Kavvadas, P., Tang, S. C. W., Yiu, W. H., Green, C. R., Potter, J. A., Siamantouras, E., Squires, P. E., & Hills, C. E. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00558-1 · Cited by 58 · see citing works

Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis

Xu, H., Wang, M., Li, Y., Shi, M., Wang, Z., Cao, C., Hong, Y. A., Hu, B., Zhu, H. J., Zhao, Z., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04910-w · Cited by 56 · see citing works

Lineage determinants in early endocrine development

Rieck, S., Bankaitis, E., & Wright, C. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.06.005 · Cited by 56 · see citing works

Extracellular vesicle mediated molecular signaling in ovarian follicle: Implication for oocyte developmental competence

Tesfaye, D., Hailay, T., Salilew‐Wondim, D., Hoelker, M., Bitseha, S., & Gebremedhn, S. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.01.075 · Cited by 54 · see citing works

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

Guo-Parke, H., McCluskey, J. T., Kelly, C., Hamid, M., McClenaghan, N. H., & Flatt, P. R. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0188 · Cited by 52 · see citing works

Review: Novel insights into the regulation of vascular tone by sphingosine 1-phosphate

Kerage, D., Brindley, D. N., & Hemmings, D. G. (2013) · Placenta · doi:10.1016/j.placenta.2013.12.006 · Cited by 51 · see citing works

Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells

Lebreton, F., Pirog, A., Belouah, I., Bosco, D., Berney, T., Meda, P., Bornat, Y., Catargi, B., Renaud, S., Raoux, M., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3558-z · Cited by 49 · see citing works

Regulation of cardiovascular connexins by mechanical forces and junctions

Meens, M. J. P. M. T., Pfenniger, A., Kwak, B. R., & Delmar, M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt095 · Cited by 49 · see citing works

Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin

Wakae-Takada, N., Xuan, S., Watanabe, K., Meda, P., & Leibel, R. L. (2013) · Diabetologia · doi:10.1007/s00125-012-2824-6 · Cited by 47 · see citing works

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Desarménien, M. G., Jourdan, C., Toutain, B., Vessières, E., Hormuzdi, S. G., & Guérineau, N. C. (2013) · Nature Communications · doi:10.1038/ncomms3938 · Cited by 48 · see citing works

Connexins and β-cell functions

Cigliola, V., Chellakudam, V., Arabieter, W., & Meda, P. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.10.016 · Cited by 47 · see citing works

Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion

Alonso, F., Domingos‐Pereira, S., Gal, L. L., Derré, L., Meda, P., Jichlinski, P., Nardelli‐Haefliger, D., & Haefliger, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7370 · Cited by 47 · see citing works

Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices

Stožer, A., Klemen, M. S., Gosak, M., Bombek, L. K., Pohorec, V., Rupnik, M. S., & Dolenšek, J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2021 · Cited by 45 · see citing works

Protein-Mediated Interactions of Pancreatic Islet Cells

Meda, P. (2013) · Scientifica · doi:10.1155/2013/621249 · Cited by 50 · see citing works

Broad Gap Junction Blocker Carbenoxolone Disrupts Uterine Preparation for Embryo Implantation in Mice1

Diao, H., Xiao, S., Howerth, E. W., Zhao, F., Li, R., Ard, M. B., & Ye, X. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.110106 · Cited by 45 · see citing works

Connexins in lymphatic vessel physiology and disease

Meens, M. J., Sabine, A., Petrova, T. V., & Kwak, B. R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.01.011 · Cited by 44 · see citing works

Connexin 43: a New Therapeutic Target Against Chronic Kidney Disease

Prakoura, N., Kavvadas, P., & Chadjichristos, C. E. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493230 · Cited by 42 · see citing works

Mathematical modeling of gap junction coupling and electrical activity in human β -cells

Loppini, A., Braun, M., Filippi, S., & Pedersen, M. G. (2015) · Physical Biology · doi:10.1088/1478-3975/12/6/066002 · Cited by 39 · see citing works

Contribution of Pannexin 1 and Connexin 43 Hemichannels to Extracellular Calcium–Dependent Transport Dynamics in Human Blood-Brain Barrier Endothelial Cells

Kaneko, Y., Tachikawa, M., Akaogi, R., Fujimoto, K., Ishibashi, M., Uchida, Y., Couraud, P., Ohtsuki, S., Hosoya, K., & Terasaki, T. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220210 · Cited by 41 · see citing works

Gap junction proteins are key drivers of endocrine function

Meda, P. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.005 · Cited by 41 · see citing works

Retinoids Regulate the Formation and Degradation of Gap Junctions in Androgen-Responsive Human Prostate Cancer Cells

Kelsey, L. S., Katoch, P., Johnson, K. E., Batra, S. K., & Mehta, P. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032846 · Cited by 38 · see citing works

Heterogeneity and Delayed Activation as Hallmarks of Self-Organization and Criticality in Excitable Tissue

Stožer, A., Markovič, R., Dolenšek, J., Perc, M., Marhl, M., Rupnik, M. S., & Gosak, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00869 · Cited by 36 · see citing works

Restoration of Connexin 40 (Cx40) in Renin-Producing Cells Reduces the Hypertension of Cx40 Null Mice

Gal, L. L., Alonso, F., Wagner, C., Germain, S., Nardelli‐Haefliger, D., Meda, P., & Haefliger, J. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02976 · Cited by 36 · see citing works

Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release

Meens, M. J. P. M. T., Alonso, F., Gal, L. L., Kwak, B. R., & Haefliger, J. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0110-1 · Cited by 35 · see citing works

Assessing Different Temporal Scales of Calcium Dynamics in Networks of Beta Cell Populations

Zmazek, J., Klemen, M. S., Markovič, R., Dolenšek, J., Marhl, M., Stožer, A., & Gosak, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.612233 · Cited by 34 · see citing works

Functional Chromaffin Cell Plasticity in Response to Stress: Focus on Nicotinic, Gap Junction, and Voltage-Gated Ca2+ Channels

Guérineau, N. C., Desarménien, M. G., Carabelli, V., & Carbone, E. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9707-7 · Cited by 35 · see citing works

Roles of connexins and pannexins in (neuro)endocrine physiology

Hodson, D. J., Legros, C., Desarménien, M. G., & Guérineau, N. C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1967-2 · Cited by 34 · see citing works

Connexin Mutations and Hereditary Diseases

Qiu, Y., Zheng, J., Chen, S., & Sun, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084255 · Cited by 34 · see citing works

Connexin 36, a key element in pancreatic beta cell function

Pérez-Armendáriz, E. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.015 · Cited by 34 · see citing works

Plasticity of the Prolactin (PRL) Axis: Mechanisms Underlying Regulation of Output in Female Mice

Tissier, P. L., Hodson, D. J., Martin, A., Romanò, N., & Mollard, P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-12114-7_6 · Cited by 33 · see citing works

Novel Targets for Therapy of Renal Fibrosis

Prakoura, N., Hadchouel, J., & Chatziantoniou, C. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419849386 · Cited by 32 · see citing works

NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis

Šterk, M., Bombek, L. K., Klemen, M. S., Rupnik, M. S., Marhl, M., Stožer, A., & Gosak, M. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009002 · Cited by 29 · see citing works

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

Stožer, A., Sterk, M., Leitgeb, E. P., Markovič, R., Klemen, M. S., Ellis, C., Bombek, L. K., Dolenšek, J., Macdonald, P., & Gosak, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.922640 · Cited by 28 · see citing works

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

Hill, T. G., Gao, R., Benrick, A., Kothegala, L., Rorsman, N., Santos, C., Acreman, S., Briant, L. J., Dou, H., Gandasi, N. R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01139-z · Cited by 30 · see citing works

Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis

Dolenšek, J., Spelic, D., Klemen, M. S., Žalik, B., Gosak, M., Rupnik, M. S., & Stožer, A. (2015) · Italian National Conference on Sensors · doi:10.3390/s151127393 · Cited by 27 · see citing works

Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity

Allagnat, F., Klee, P., Cardozo, A. K., Meda, P., & Haefliger, J. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.134 · Cited by 29 · see citing works

Targeting Cx40 (Connexin40) Expression or Function Reduces Angiogenesis in the Developing Mouse Retina

Haefliger, J., Allagnat, F., Hamard, L., Gal, L. L., Meda, P., Nardelli‐Haefliger, D., Genot, E. M., & Alonso, F. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310072 · Cited by 30 · see citing works

Learning Theories Reveal Loss of Pancreatic Electrical Connectivity in Diabetes as an Adaptive Response

Goel, P., & Mehta, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070366 · Cited by 30 · see citing works

The In Vivo β-to-β-Cell Chat Room: Connexin Connections Matter

Meda, P. (2012) · Diabetes · doi:10.2337/db12-0336 · Cited by 29 · see citing works

Extracellular Vesicles as Mediators of Environmental and Metabolic Stress Coping Mechanisms During Mammalian Follicular Development

Gebremedhn, S., Ali, A., Gad, A. Y., Procházka, R., & Tesfaye, D. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.602043 · Cited by 28 · see citing works

Mitochondrial Dysfunction in Pancreatic Alpha and Beta Cells Associated with Type 2 Diabetes Mellitus

Grubelnik, V., Zmazek, J., Markovič, R., Gosak, M., & Marhl, M. (2020) · Life · doi:10.3390/life10120348 · Cited by 28 · see citing works

The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans

Striegel, D., Hara, M., & Periwal, V. (2015) · PLoS Comput. Biol. · doi:10.1371/journal.pcbi.1004423 · Cited by 27 · see citing works

The molecular and immunochemical expression of innexins in the yellow fever mosquito, Aedes aegypti: Insights into putative life stage- and tissue-specific functions of gap junctions

Calkins, T. L., Acevedo, M. A. W., Hildebrandt, O., & Piermarini, P. M. (2015) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2014.11.013 · Cited by 27 · see citing works

Intercellular Communication in the Islet of Langerhans in Health and Disease

Ng, X. W., Chung, Y. H., & Piston, D. W. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200026 · Cited by 39 · see citing works

Transcellular Neuroligin-2 Interactions Enhance Insulin Secretion and Are Integral to Pancreatic β Cell Function

Suckow, A. T., Zhang, C., Egodage, S., Comoletti, D., Taylor, P., Miller, M. T., Sweet, I. R., & Chessler, S. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.280537 · Cited by 26 · see citing works

Mind the gap: connexins and cell–cell communication in the diabetic kidney

Hills, C. E., Price, G. W., & Squires, P. E. (2014) · Diabetologia · doi:10.1007/s00125-014-3427-1 · Cited by 25 · see citing works

Connexin-dependent signaling in neuro-hormonal systems

Potolicchio, I., Cigliola, V., Velázquez-García, S., Klee, P., Valjevac, A., Kapić, D., Ćosović, E., Lepara, O., Hadžović-Džuvo, A., Mornjacovic, Z., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.09.022 · Cited by 25 · see citing works

Connexins, important players in the dissemination of prostate cancer cells

Boucher, J., Monvoisin, A., Vix, J., Mesnil, M., Thuringer, D., Debiais, F., & Cronier, L. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.06.020 · Cited by 25 · see citing works

Functional characteristics of hub and wave-initiator cells in β cell networks

Šterk, M., Dolenšek, J., Klemen, M. S., Bombek, L. K., Leitgeb, E. P., Kerčmar, J., Perc, M., Rupnik, M. S., Stožer, A., & Gosak, M. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.01.039 · Cited by 26 · see citing works

Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture

Liu, X., Yan, F., Yao, H., Chang, M., Qin, J., Li, Y., Wang, Y., & Pei, X. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1961-2 · Cited by 23 · see citing works

Current knowledge and the future potential of extracellular vesicles in mammalian reproduction

Tesfaye, D., Menjivar, N. G., & Gebremedhn, S. (2021) · Reproduction Fertility and Development · doi:10.1071/rd21277 · Cited by 23 · see citing works

HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes

Si, R., Cabrera, J. T. O., Tsuji‐Hosokawa, A., Guo, R., Watanabe, M., Gao, L., Lee, Y. S., Moon, J.-S., Scott, B. T., Wang, J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147982 · Cited by 23 · see citing works

Role of Connexins and Pannexins in the Pancreas

Cigliola, V., Allagnat, F., Berchtold, L. A., Lamprianou, S., Haefliger, J., & Meda, P. (2015) · Pancreas · doi:10.1097/mpa.0000000000000378 · Cited by 23 · see citing works

Exosome‐based intercellular communication in female reproductive microenvironments

Ranjbaran, A., Latifi, Z., Nejabati, H. R., Abroon, S., Mihanfar, A., Sadigh, A. R., Fattahi, A., Nouri, M., & Raffel, N. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28668 · Cited by 23 · see citing works

Connexins as therapeutic targets in neurological and neuropsychiatric disorders

Charvériat, M., Mouthon, F., Rein, W., & Verkhratsky, A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166098 · Cited by 22 · see citing works

Multilayer network representation of membrane potential and cytosolic calcium concentration dynamics in beta cells

Gosak, M., Dolenšek, J., Markovič, R., Rupnik, M., Marhl, M., & Stožer, A. (2015) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2015.06.009 · Cited by 20 · see citing works

Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles

Haefliger, J., Martin, D. J., Favre, D., Petremand, Y., Mazzolai, L., Abderrahmani, A., Meda, P., Waeber, G., & Allagnat, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055198 · Cited by 22 · see citing works

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

Haefliger, J., Rohner‐Jeanrenaud, F., Caille, D., Charollais, A., Meda, P., & Allagnat, F. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0054 · Cited by 22 · see citing works

Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells

Tachikawa, M., Murakami, K., Akaogi, R., Akanuma, S., Terasaki, T., & Hosoya, K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104600 · Cited by 21 · see citing works

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

Cigliola, V., Populaire, C., Pierri, C. L., Deutsch, S., Haefliger, J., Fadista, J., Lyssenko, V., Groop, L., Rueedi, R., Thorel, F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150880 · Cited by 20 · see citing works

Vitamin D3 Regulates the Formation and Degradation of Gap Junctions in Androgen-Responsive Human Prostate Cancer Cells

Kelsey, L. S., Katoch, P., Ray, A., Mitra, S., Chakraborty, S., Lin, M., & Mehta, P. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106437 · Cited by 20 · see citing works

Rational design of new NO and redox sensitivity into connexin26 hemichannels

Meigh, L., Cook, D., Zhang, J., & Dale, N. (2015) · Open Biology · doi:10.1098/rsob.140208 · Cited by 21 · see citing works

Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

Rozas-Villanueva, M. F., Casanello, P. C., & Retamal, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134698 · Cited by 21 · see citing works

Gap junction proteins: Master regulators of the planarian stem cell response to tissue maintenance and injury

Peiris, T. H., & Oviedo, N. J. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.03.005 · Cited by 18 · see citing works

Risky communication in atherosclerosis and thrombus formation

Meens, M. J. P. M. T., Pfenniger, A., & Kwak, B. R. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13553 · Cited by 18 · see citing works

Altered Pancreatic Islet Function and Morphology in Mice Lacking the Beta-Cell Surface Protein Neuroligin-2

Zhang, C., Suckow, A. T., & Chessler, S. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065711 · Cited by 18 · see citing works

The Carboxyl Tail of Connexin32 Regulates Gap Junction Assembly in Human Prostate and Pancreatic Cancer Cells

Katoch, P., Mitra, S., Ray, A., Kelsey, L. S., Roberts, B. J., Wahl, J. K., Johnson, K. R., & Mehta, P. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586057 · Cited by 17 · see citing works

Exosomes as Potential Biomarkers for Erectile Dysfunction, Varicocele, and Testicular Injury

Khodamoradi, K., Golan, R., Dullea, A. D., & Ramasamy, R. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.10.001 · Cited by 17 · see citing works

CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes

Yang, Y., Li, J., Zhang, L., Lin, Z., Xiao, H., Sun, X., Zhang, M., Liu, P., & Huang, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105333 · Cited by 16 · see citing works

DNMT1-mediated NR3C1 DNA methylation enables transcription activation of connexin40 and augments angiogenesis during colorectal cancer progression

Zhai, P. C., Zhang, H., Li, Q., Yang, M. W., Guo, Y., & Xing, C. (2023) · Gene · doi:10.1016/j.gene.2023.147887 · Cited by 16 · see citing works

The Intercellular Synchronization of Ca2+ Oscillations Evaluates Cx36-Dependent Coupling

Bavamian, S., Pontes, H., Cancela, J., Charollais, A., Startchik, S., Ville, D. V. D., & Meda, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041535 · Cited by 15 · see citing works

Structure of an innexin gap junction channel and cryo-EM sample preparation

Oshima, A. (2017) · Microscopy · doi:10.1093/jmicro/dfx035 · Cited by 15 · see citing works

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!

Leroy, J., Meulders, B., Moorkens, K., Xhonneux, I., Slootmans, J., Keersmaeker, L. D., Smits, A., Pascottini, O. B., & Marei, W. F. A. (2022) · Reproduction Fertility and Development · doi:10.1071/rd22204 · Cited by 15 · see citing works

Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model perspective

Šterk, M., Barać, U., Stožer, A., & Gosak, M. (2023) · Physical review. E · doi:10.1103/physreve.108.054409 · Cited by 16 · see citing works

Connexin‐mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?

Price, G. W., Potter, J. A., Williams, B. M., Cliff, C. L., Squires, P. E., & Hills, C. E. (2019) · Experimental Physiology · doi:10.1113/ep087770 · Cited by 15 · see citing works

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

Potter, J. A., Price, G. W., Cliff, C. L., Green, C. R., Squires, P. E., & Hills, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073644 · Cited by 15 · see citing works

Antagonistic Functions of Connexin 43 during the Development of Primary or Secondary Bone Tumors

Talbot, J., Dupuy, M., Morice, S., Rédiní, F., & Verrecchia, F. (2020) · Biomolecules · doi:10.3390/biom10091240 · Cited by 14 · see citing works

Glucose-stimulated insulin secretion: the hierarchy of its multiple cellular and subcellular mechanisms

Meda, P., & Schuit, F. C. (2013) · Diabetologia · doi:10.1007/s00125-013-3073-z · Cited by 14 · see citing works

Weight of time: exploring the link between obesity and aging

Ragusa, F. S., Tanaka, T., Veronese, N., Mansueto, P., Dominguez, L. J., Barbagallo, M., & Ferrucci, L. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03106-4 · Cited by 13 · see citing works

Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions

Ray, A., Katoch, P., Jain, N., & Mehta, P. P. (2018) · Journal of Cell Science · doi:10.1242/jcs.207340 · Cited by 13 · see citing works

Comparative genomic analysis of eutherian connexin genes

Premzl, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-53458-x · Cited by 13 · see citing works

Targeting connexin37 alters angiogenesis and arteriovenous differentiation in the developing mouse retina

Hamard, L., Santoro, T., Allagnat, F., Meda, P., Nardelli‐Haefliger, D., Alonso, F., & Haefliger, J. (2020) · The FASEB Journal · doi:10.1096/fj.202000257r · Cited by 13 · see citing works

Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney

Squires, P. E., Price, G. W., Mouritzen, U., Potter, J. A., Williams, B. M., & Hills, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062809 · Cited by 13 · see citing works

Connexin-dependent signaling in neuro-hormonal systems

Potolicchio, I., Cigliola, V., Velázquez-García, S., Klee, P., Valjevac, A., Kapić, D., Ćosović, E., Lepara, O., Hadžović-Džuvo, A., Mornjacovic, Z., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.09.022 · Cited by 25 · see citing works

Gap junction proteins are key drivers of endocrine function

Meda, P. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.005 · Cited by 41 · see citing works

Jonctions communicantes et sécrétion

Haefliger, J., Allagnat, F., Krattinger, N., Martin, D., Waeber, G., & Meda, P. (2005) · JMIG · doi:10.53738/revmed.2005.1.17.1134

Cx36 and the Function of Endocrine Pancreas

Calabrese, A., Güldenagel, M., Charollais, A., Mas, C., Caton, D., Bauquis, J., Serre‐Beinier, V., Caille, D., Söhl, G., Teubner, B., et al. (2001) · Cell Communication & Adhesion · doi:10.3109/15419060109080759 · Cited by 19 · see citing works

Beta-cell crosstalk: a further dimension in the stimulus-secretion coupling of glucose-induced insulin release.

Caton, D., Calabrese, A., Mas, C., Serre‐Beinier, V., Wonkam, A., & Meda, P. (2002) · PubMed · Cited by 26 · see citing works