Fibromodulin regulates collagen fibrillogenesis during peripheral corneal development
Open accessAbstract
Fibromodulin regulates collagen fibrillogenesis, but its existence/role(s) in the cornea is controversial. We hypothesize that fibromodulin regulates fibrillogenesis during postnatal development of the anterior eye. Fibromodulin is weakly expressed in the limbus at post‐natal day (P) 4, increases and extends into the central cornea at P14, becomes restricted to the limbus at P30, and decreases at P60. This differential spatial and temporal expression of fibromodulin is coordinated with emmetropization; the developmental increase in axial length and globe size. Genetic analysis demonstrated that fibromodulin regulates fibrillogenesis in a region‐specific manner. At the limbus, fibromodulin is dominant in regulating fibril growth during postnatal development. In the posterior peripheral cornea, cooperative interactions of fibromodulin and lumican regulate fibrillogenesis. These data indicate that fibromodulin plays important roles in the regulation of region‐specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis. Developmental Dynamics 239:844–854, 2010. © 2010 Wiley‐Liss, Inc.
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Fibromodulin plays a major role in development of the peripheral cornea but its presence in the normal cornea is uncertain.
“fibromodulin plays a major role in development of the peripheral cornea but its presence in the normal cornea is uncertain (Chen et al., 2010).”
From Corneal structure and transparency (2015) · cites this paper as Chen et al., 2010
The Discussion supports an important role for fibromodulin in peripheral corneal development. But although the Results call its presence in mature corneal stroma controversial, the paper then reports barely detectable levels at P90 and concludes that fibromodulin is not a component of mature corneal stroma. It does not leave its presence in the adult cornea uncertain. (LLM, conf=0.88)
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Research works printed but not linked: 33
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Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
- Authors
- Chen, S., Oldberg, A., Chakravarti, S., & Birk, D. E.
- Affiliations
- University of South Florida (US)
- Johns Hopkins University (US)
- Corresponding author
- Birk, David E.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2010-01-27
- Volume
- 239
- Issue
- 3
- Pages
- 844-854
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- PMC
- PMC2965449
- OpenAlex
- W2117738517
- Cited by
- 60
- References
- 0
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Eye Institute (EY11654, R01EY005129, R01EY011654, EY05129, R56EY011654)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Keywords
- fibromodulin, collagen fibrillogenesis, corneal development, limbus, emmetropization, axial length, lumican, corneal collagen
- MeSH terms
- Lumican, Fibromodulin, Animals, Collagen, Cornea, Extracellular Matrix, Keratan Sulfate, Mice, Transgenic, Models, Genetic, Chondroitin Sulfate Proteoglycans, Proteoglycans, RNA, Messenger, Tendons, Time Factors, Vision, Ocular, Extracellular Matrix Proteins, Gene Expression Regulation, Developmental, Microscopy, Electron, Transmission, Mice
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