A Tlx2-Cre mouse line uncovers essential roles for hand1 in extraembryonic and lateral mesoderm

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

Danielian, P. S., Muccino, D. R., Rowitch, D. H., Michael, S. K., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00562-3 · Cited by 1,295 · see citing works

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

Riley, P. R., Anaon-Cartwight, L., & Cross, J. C. (1998) · Nature Genetics · doi:10.1038/ng0398-271 · Cited by 536 · see citing works

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., & Olson, E. N. (1998) · Nature Genetics · doi:10.1038/ng0398-266 · Cited by 387 · see citing works

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner

McFadden, D. G., Barbosa, A. C. C., Richardson, J. A., Schneider, M. D., Srivastava, D., & Olson, E. N. (2004) · Development · doi:10.1242/dev.01562 · Cited by 344 · see citing works

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

Mao, X., Fujiwara, Y., & Orkin, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5037 · Cited by 332 · see citing works

Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice

Kothary, R., Clapoff, S., Darling, S. M., Perry, M. D., Moran, L. A., & Rossant, J. (1989) · Development · doi:10.1242/dev.105.4.707 · Cited by 323 · see citing works

Expression of the Novel Basic Helix-Loop-Helix Gene eHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

Cserjesi, P., Brown, D. R., Lyons, G. E., & Olson, E. N. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1245 · Cited by 250 · see citing works

BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium

Stottmann, R. W., Choi, M., Mishina, Y. M., Meyers, E. N., & Klingensmith, J. (2004) · Development · doi:10.1242/dev.01086 · Cited by 186 · see citing works

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development

Tang, S. J., Hoodless, P. A., Lü, Z., Breitman, M. L., McInnes, R. R., Wrana, J. L., & Buchwald, M. (1998) · Development · doi:10.1242/dev.125.10.1877 · Cited by 103 · see citing works

Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding

McFadden, D. G., McAnally, J., Richardson, J. A., Charité, J., & Olson, E. N. (2002) · Development · doi:10.1242/dev.129.13.3077 · Cited by 102 · see citing works

Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system

Morikawa, Y., D’Autréaux, F., Gershon, M. D., & Cserjesi, P. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.027 · Cited by 100 · see citing works

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

Morikawa, Y., Zehir, A., Maska, E. L., Deng, C., Schneider, M. D., Mishina, Y. M., & Cserjesi, P. (2009) · Development · doi:10.1242/dev.038133 · Cited by 99 · see citing works

Extra-embryonic vasculature development is regulated by the transcription factor HAND1

Morikawa, Y., & Cserjesi, P. (2004) · Development · doi:10.1242/dev.01091 · Cited by 86 · see citing works

Hand2is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia

D’Autréaux, F., Morikawa, Y., Cserjesi, P., & Gershon, M. D. (2007) · Development · doi:10.1242/dev.003814 · Cited by 80 · see citing works

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field Development

Morikawa, Y., & Cserjesi, P. (2008) · Circulation Research · doi:10.1161/circresaha.108.180083 · Cited by 78 · see citing works

Hand2 is required in the epithelium for palatogenesis in mice

Xiong, W., He, F., Morikawa, Y., Yu, X., Zhang, Z., Lan, Y., Jiang, R., Cserjesi, P., & Chen, Y. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.03.021 · Cited by 76 · see citing works

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme

Barbosa, A. C. C., Funato, N., Chapman, S. L., McKee, M. D., Richardson, J. A., Olson, E. N., & Yanagisawa, H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.07.036 · Cited by 66 · see citing works

Ncx , a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells

Hatano, M., Iitsuka, Y., Yamamoto, H., Dezawa, M., Yusa, S.-I., Kohno, Y., & Tokuhisa, T. (1997) · Anatomy and Embryology · doi:10.1007/s004290050061 · Cited by 52 · see citing works

Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1−/− mice1 1The authors thank Carmen Booth for technical assistance and Kristy Seidel for statistical analysis.

Parisi, M. A., Baldessari, A. E., Iida, M. H. K., Clarke, C. M., Doggett, B., Shirasawa, S., & Kapur, R. P. (2003) · Gastroenterology · doi:10.1016/j.gastro.2003.08.021 · Cited by 28 · see citing works

Targeted expression of Cre recombinase to myelinating cells of the central nervous system in transgenic mice

Niwa‐Kawakita, M., Abramowski, V., Kalamarides, M., Thomas, G. D., & Giovannini, M. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 22 · see citing works

cHox11L2, a Hox11 related gene, is expressed in the peripheral nervous system and subpopulation of the spinal cord during chick development

Uchiyama, K., Otsuka, R., & Hanaoka, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00637-0 · Cited by 13 · see citing works

An Enhancer Element for Expression of the Ncx (Enx, Hox11L1) Gene in Neural Crest-derived Cells

Iitsuka, Y., Shimizu, H., Kang, M. M., Sasagawa, K., Sekiya, S., Tokuhisa, T., & Hatano, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24401 · Cited by 12 · see citing works

Hox11L1 Expression by Precursors of Enteric Smooth Muscle: An Alternative Explanation for Megacecum in Hox11L1-/- Mice

Kapur, R. P., Clarke, C. M., Doggett, B., Taylor, B. E., Baldessari, A. E., Parisi, M. A., & Howe, D. G. (2005) · Pediatric and Developmental Pathology · doi:10.1007/s10024-005-1126-0 · Cited by 9 · see citing works

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra‐embryonic, and lateral mesoderm derivatives

Barnes, R. M., Firulli, B. A., Conway, S. J., Vincentz, J. W., & Firulli, A. B. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22428 · Cited by 103 · see citing works

Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages

Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86 · see citing works

The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development

Ritter, N. J., Ali, T., Kopitchinski, N., Schuster, P., Beisaw, A., Hendrix, D. A., Schulz, M. H., Müller-McNicoll, M., Dimmeler, S., & Grote, P. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.07.013 · Cited by 85 · see citing works

Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

Palpant, N. J., Pabon, L., Redd, M. A., Hadland, B., Jones, D. C., Jones, C., Moon, R. T., Ruzzo, W. L., Bernstein, I. D., Zheng, Y. Y., et al. (2015) · Development · doi:10.1242/dev.117010 · Cited by 64 · see citing works

Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages

Sun, Y., Wang, L., Zhu, T., Wu, B., Wang, G., Luo, Z., Li, C., Wei, W., & Liu, Z. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110542 · Cited by 46 · see citing works

Identification of Thymosin β4 as an effector of Hand1-mediated vascular development

Smart, N., Dubé, K. N., & Riley, P. R. (2010) · Nature Communications · doi:10.1038/ncomms1041 · Cited by 39 · see citing works

The developmental origins and lineage contributions of endocardial endothelium

Nakano, A., Nakano, H., Smith, K., & Palpant, N. J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.022 · Cited by 36 · see citing works

The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice

Firulli, B. A., Toolan, K. P., Harkin, J., Millar, H., Pineda, S. B., & Firulli, A. B. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx166 · Cited by 17 · see citing works

Gastrulation-stage gene expression in Nipbl +/− mouse embryos foreshadows the development of syndromic birth defects

Chea, S., Kreger, J., Lopez‐Burks, M. E., MacLean, A. L., Lander, A. D., & Calof, A. L. (2024) · Science Advances · doi:10.1126/sciadv.adl4239 · Cited by 13 · see citing works

The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer

Hu, D., Scott, I. C., Snider, F., Geary-Joo, C., Zhao, X., Simmons, D. G., & Cross, J. C. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.07.025 · Cited by 11 · see citing works

Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology

Formstone, C. J., Aldeiri, B., Davenport, M., & Francis‐West, P. H. (2024) · Developmental Dynamics · doi:10.1002/dvdy.735 · Cited by 7 · see citing works

Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screensPreprint

Regalado, S. G., Qiu, C., Lalanne, J., Martin, B., Duran, M., Trapnell, C., Keith, A., Domcke, S., & Shendure, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.23.655669 · Cited by 6 · see citing works

Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently of mesothelial fate

Alsukari, S. H., Ng, H. T., Lang, L., Lunn, S., Beglinger, S., Carr, L., Boyes, M., Turner, D. A., & Wilm, B. (2025) · Development · doi:10.1242/dev.204332 · Cited by 3 · see citing works

A show of Hands : Novel and conserved expression patterns of teleost hand paralogs during craniofacial, heart, fin, peripheral nervous system and gut development

Reynolds, S., Pierce, C., Powell, B., Kite, A., Hall‐Ruiz, N., Schilling, T. F., & Pabic, P. L. (2021) · Developmental Dynamics · doi:10.1002/dvdy.380 · Cited by 3 · see citing works

Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects

Firulli, B. A., Ferguson, C. A., Vries, C. D. G.-D., Podicheti, R., Rusch, D. B., Christoffels, V. M., Rubart, M., & Firulli, A. B. (2025) · Development · doi:10.1242/dev.204963 · Cited by 2 · see citing works

Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation

Yu, Y., Mu, C., Xu, Y., Li, Y., Ren, S., Kong, S., Deng, W., Wang, Y., Wang, H., & Lu, J. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103753 · Cited by 1 · see citing works

Differential requirement of Hand1 during differentiation of lateral plate mesoderm lineages in Xenopus laevis

Deveau, V. A., Willson, J. A., Carleton, J., & Drysdale, T. A. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.06.005

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., & Olson, E. N. (1998) · Nature Genetics · doi:10.1038/ng0398-266 · Cited by 387 · see citing works

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability

Firulli, B. A., McConville, D. P., Byers, J. S., Vincentz, J. W., Barnes, R. M., & Firulli, A. B. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22402 · Cited by 27 · see citing works

Differential requirement of Hand1 during differentiation of lateral plate mesoderm lineages in Xenopus laevis

Deveau, V. A., Willson, J. A., Carleton, J., & Drysdale, T. A. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.06.005

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra‐embryonic, and lateral mesoderm derivatives

Barnes, R. M., Firulli, B. A., Conway, S. J., Vincentz, J. W., & Firulli, A. B. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22428 · Cited by 103 · see citing works

Early Exclusion of Hand1-Deficient Cells from Distinct Regions of the Left Ventricular Myocardium in Chimeric Mouse Embryos

Riley, P. R., Gertsenstein, M., Dawson, K. M., & Cross, J. C. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9864 · Cited by 60 · see citing works