The 5-HTTLPR polymorphism and eating disorders: A meta-analysis
Abstract
OBJECTIVE: Eating disorders are influenced by both environmental factors and genes. The 5-HTTLPR polymorphism of serotonin transporter gene has been suggested as a good candidate. This meta-analysis was undertaken: (1) to investigate the association between 5-HTTLPR and eating disorders considered as a whole, including anorexia (AN), bulimia (BN), and binge eating disorder (BED); (2) to extend recently reported findings on the association between 5-HTTLPR and AN-BN. METHOD: PubMed, ISI, and PsycINFO databases were searched for studies published until October 2009. Fifteen studies have been included. Data were analyzed with the Cochrane Collaboration Review Manager Software. Quality of studies and publication bias were assessed. RESULTS: An association between S allele and eating disorders, in particular AN, has been found. DISCUSSION: To be carrier of the 5-HTTLPR S allele seem to represent a risk factor for eating disorders, especially for AN. However, considering the reported high between-study heterogeneity, future studies should focus on more homogeneous endophenotype.
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Meta-analysis has linked the 5HTTLPR allele strongest to anorexia nervosa, and to date no study has linked this polymorphism to food addiction.
“However, meta-analysis has linked the 5HTTLPR allele strongest to AN [111] and to date no study has linked this polymorphism to FA.”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [111]
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- Authors
- Calati, R., De Ronchi, D., Bellini, M., & Serretti, A.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Serretti, Alessandro
- Venue
- International Journal of Eating Disorders
- Publisher
- Wiley
- Published
- 2011-03-11
- Volume
- 44
- Issue
- 3
- Pages
- 191-199
- ISSN
- 0276-3478 (ISSN-L)
- 1098-108X
- OpenAlex
- W2160415307
- Cited by
- 91
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 15 · 2012: 7
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Eating Disorders (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- 5-HTTLPR polymorphism, serotonin transporter gene, eating disorders, anorexia nervosa, bulimia nervosa, binge eating disorder, S-alleles, genetic risk factors, endophenotypes
- MeSH terms
- Alleles, Feeding and Eating Disorders, Genotype, Humans, Polymorphism, Genetic, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins
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