Cardiac adaptations to 60 day head-down-tilt bed rest deconditioning. Findings from the AGBRESA study
Open accessAbstract
AIMS: Reduced physical activity increases the risk of heart failure; however, non-invasive methodologies detecting subclinical changes in myocardial function are not available. We hypothesized that myocardial, left ventricular, systolic strain measurements could capture subtle abnormalities in myocardial function secondary to physical inactivity. METHODS AND RESULTS: In the AGBRESA study, which assessed artificial gravity through centrifugation as potential countermeasure for space travel, 24 healthy persons (eight women) were submitted to 60 day strict -6° head-down-tilt bed rest. Participants were assigned to three groups of eight subjects: a control group, continuous artificial gravity training on a short-arm centrifuge (30 min/day), or intermittent centrifugation (6 × 5 min/day). We assessed cardiac morphology, function, strain, and haemodynamics by cardiac magnetic resonance imaging (MRI) and echocardiography. We observed no differences between groups and, therefore, conducted a pooled analysis. Consistent with deconditioning, resting heart rate (∆8.3 ± 6.3 b.p.m., P < 0.0001), orthostatic heart rate responses (∆22.8 ± 19.7 b.p.m., P < 0.0001), and diastolic blood pressure (∆8.8 ± 6.6 mmHg, P < 0.0001) increased, whereas cardiac output (∆-0.56 ± 0.94 L/min, P = 0.0096) decreased during bed rest. Left ventricular mass index obtained by MRI did not change. Echocardiographic left ventricular, systolic, global longitudinal strain (∆1.8 ± 1.83%, P < 0.0001) decreased, whereas left ventricular, systolic, global MRI circumferential strain increased not significantly (∆-0.68 ± 1.85%, P = 0.0843). MRI values rapidly returned to baseline during recovery. CONCLUSION: Prolonged head-down-tilt bed rest provokes changes in cardiac function, particularly strain measurements, that appear functional rather than mediated through cardiac remodelling. Thus, strain measurements are of limited utility in assessing influences of physical deconditioning or exercise interventions on cardiac function.
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“Numerous negative health effects are associated with reduced physical activity and immobilization, including decreases in muscle and bone mass (4, 5), cardiovascular pathology (6), and deep vein thrombosis (7).”
BackgroundGravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications
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- Authors
- Hoffmann, F., Rabineau, J., Mehrkens, D., Gerlach, D. A., Moestl, S., Johannes, B. W., Caiani, E. G., Migeotte, P. F., Jordan, J., & Tank, J.
- Affiliations
- University of Cologne (DE)
- Université Libre de Bruxelles (BE)
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- National Research Council (IT)
- LPHYS, Université Libre de Bruxelles , Bruxelles ,
- Corresponding author
- Hoffmann, Fabian
- ORCID
- Venue
- ESC Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-15
- Volume
- 8
- Issue
- 1
- Pages
- 729-744
- ISSN
- 2055-5822 (ISSN-L)
- PMC
- PMC7835618
- OpenAlex
- W3106082418
- Cited by
- 42
- References
- 29
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 12 · 2021: 3 · 2020: 1
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- ESC Heart Failure (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- elib (German Aerospace Center) (acceptedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fonds de la Recherche Scientifique (29801)
- German Federal Ministry of Economy and Technology (50WB1816)
- German Aerospace Center
- Fonds De La Recherche Scientifique - FNRS (29801)
- Deutsches Zentrum für Luft- und Raumfahrt
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- head-down bed rest, cardiac deconditioning, physical inactivity, myocardial strain, global longitudinal strain, circumferential strain, left ventricular function, artificial gravity, heart rate, cardiac output, diastolic blood pressure, cardiac remodeling, heart failure risk
- MeSH terms
- Bed Rest, Blood Pressure, Female, Heart, Humans, Gravity, Altered, Head-Down Tilt
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