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Cited by 49Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

Relationship Between Body Roundness Index and the Risk of Heart Failure in Chinese Adults: The Kailuan Cohort Study

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Wang, Jianing, Wu, Mingyang, Wu, Shouling, Tian, Yaohua·2022·ESC Heart Failure
DOI 10.1002/ehf2.13820PMC PMC8934936
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Abstract

Aims: Body roundness index (BRI) is an obesity-related anthropometric index that combines waist circumference and height to better reflect body fat. This study aims to prospectively explore the relationship between BRI and the risk of heart failure (HF) based on a community-based cohort. Methods and results: A total of 140 362 individuals without tumour and HF at baseline were included from the Kailuan cohort study. Their demographic information, anthropometric parameters, and biochemical indexes were collected or measured. The participants were followed up until 31 December 2016 or death or diagnosed with HF, whichever came first. Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident HF. Restricted cubic spline analysis was applied to further evaluate the possible non-linear dose–response relationship between BRI and the risk of HF. After a median follow-up period of 9.84 years, we identified 1990 HF events. The participants were grouped into four groups according to the quartiles of BRI (Q1: ≤2.93, Q2: 2.93–3.59, Q3: 3.59–4.38, and Q4: ≥4.38). After adjustment for potential confounders, compared with the group of participants in the lowest quartile of BRI, the adjusted HRs (95%CI) were 1.03 (95%CI: 0.87–1.22), 1.27 (95%CI: 1.07–1.49), and 1.50 (95%CI: 1.26–1.78) for subjects in the Q2, Q3, and Q4 groups, respectively. With each standard deviation (here is 1.10) of BRI increasing, the risk of HF increased by 18% (HR: 1.18, 95%CI: 1.12–1.24). Subgroup analysis indicated that the association between BRI and HF was more prominent in younger people (HR: 2.94, 95%CI: 1.80–4.80) than older (HR: 1.89, 95%CI: 1.57–2.27) (P for interaction < 0.001). A significant linear dose–response relationship between BRI and HF was also observed (P for non-linearity = 0.730). Conclusions: Our study suggests that higher BRI is associated with an increased risk of HF. If these findings can be replicated in other populations, future studies need to examine whether lowering the BRI may lower the risk of incident HF.

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  • BRI is well-documented as a robust predictor of diabetes, including prediabetes, cardiometabolic disorders, and metabolic syndrome.

    “The BRI is well-documented as a robust predictor of diabetes, including prediabetes, cardiometabolic disorders, and metabolic syndrome32–34.”

    From The nonlinear association between body roundness index and infertility in married women (2025) · cites this paper as [32]

    The Introduction (page unavailable) says prior studies identified BRI as a risk factor for diabetes mellitus, coronary artery disease, and carotid atherosclerosis. It does not address prediabetes or metabolic syndrome, or establish that BRI is a robust predictor of those conditions. This study's own results concern heart failure. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Wang, J., Wu, M., Wu, S., & Tian, Y.
Affiliations
  • Huazhong University of Science and Technology (CN)
  • North China University of Science and Technology (CN)
Corresponding author
  • Wu, Shouling
  • Tian, Yaohua
ORCID
Venue
ESC Heart Failure
Publisher
Oxford University Press (OUP)
Published
2022-02-01
Volume
9
Issue
2
Pages
1328-1337
ISSN
2055-5822 (ISSN-L)
DOI
10.1002/ehf2.13820
PMC
PMC8934936
OpenAlex
W4210473042
Cited by
49
References
2
Citations by year
2026: 11 · 2025: 24 · 2024: 5 · 2023: 8 · 2022: 1
FWCI
6.61
Type
journal article
Language
en
Open access
Licence
Locations
  • ESC Heart Failure (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
body roundness index, heart failure, waist circumference, obesity, anthropometric index, fat mass, dose-response relationship, age-stratified association, Chinese adults, cardiovascular risk
MeSH terms
Adult, Body Height, China, Heart Failure, Humans, Obesity, Risk Factors, Cohort Studies, Body Mass Index, Waist Circumference

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