Cited by 2,814Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Mechanisms linking obesity with cardiovascular disease

Van Gaal, Luc F., Mertens, Ilse L., De Block, Christophe E.·2006·Nature

Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

Integrity signals

Registry

Crossref · 10.1038/nature05487

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Obesity is strongly associated with the development of major risk factors for atherosclerotic disease such as hypertension, hyperlipidemia, and diabetes.

    “Obesity is strongly associated with the development of major risk factors for atherosclerotic disease such as hypertension, hyperlipidemia, and diabetes (79, 89, 358).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [358]

  • Endothelial dysfunction is widely present in obesity and the metabolic syndrome.

    “In addition, endothelial dysfunction is widely present in obesity and the metabolic syndrome (84, 325, 358).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [358]

  • In other populations, such as the STRONG heart study and Framingham heart study, diabetes or metabolic syndrome appear to be significant risk factors for LV hypertrophy.

    “In other populations, such as those in the STRONG heart study (native Americans of the western United States) and the Framingham heart study, diabetes or the metabolic syndrome do appear to be significant risk factors for LV hypertrophy (272, 306, 358).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [358]

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
Affiliations
University of Antwerp (BE)
Venue
Nature
Published
2006-12
Volume
444
Issue
7121
Pages
875-880
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1964607854
Cited by
2,814
References
86
Citations by year
2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
FWCI
11.30
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
MeSH terms
Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review