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Cited by 13Viral Infections and Immunology ResearchCOVID-19 Clinical Research StudiesCardiac Imaging and Diagnostics

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Cardiac Involvement in Patients Recovering from Delta Variant of COVID-19: A Prospective Multi-Parametric MRI Study

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Zhang, Lieguang, Wei, Xiaoyu, Wang, Huimin, Jiang, Rui, Tan, Zekun, Ouyang, Jienan, Li, Xiaodan, Lei, Chunliang, Liu, Hui, Liu, Jinxin·2022·ESC Heart Failure
DOI 10.1002/ehf2.13971PMC PMC9288765
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Abstract

Aims: The cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 (COVID-19) remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta Variant of COVID-19 based on multi-parametric cardiac magnetic resonance imaging (MRI). Methods and results: We prospectively assessed patients recovering from Delta Variant of COVID-19 using multi-parametric cardiac magnetic resonance imaging (MRI) between June 2021 and July 2021. Comparison was made with 25 healthy controls. Forty-four patients (median age 51 years, 28 women) recovering from Delta Variant were recruited and had a median time of 35 days between diagnosis and cardiac MRI. There were no patients with chest pain (0/44, 0%) and high sensitivity cardiac troponin T troponin elevation (median levels 2.20 pg/mL, IQR levels 0.85–4.40 pg/mL). Regarding the cardiac imaging findings, a total of 14 (32%) patients presented cardiac tissue feature abnormalities, and a total of 9 (20%) patients had a myocarditis-like injury based on cardiac MRI 2018 Lake Louise criteria. When we further assessed the T1 and T2 mapping values for of patients' individual, abnormal raised global native T1, T2, and extracellular volume were seen in 6 (14%), 6 (14%), and 4 (9%) patients, respectively. Comparing with controls, the patients had lower LV global longitudinal strain and (−22.2 ± 2.8% vs. −24.6 ± 2.0%, P < 0.001) and global circumferential strain (−20.7 ± 6.8% vs. −24.3 ± 2.9%, P = 0.014), but higher global native T1 (1318.8 ± 55.5 ms vs. 1282.9 ± 38.1 ms, P = 0.006). Four (9%) patients presented myocardial late gadolinium enhancement with subepicardial pattern mostly common seen, and two (5%) patients presented pericardial enhancement. Conclusions: The cardiac MRI could detect subclinical functional and myocardial tissue characteristic abnormalities in individuals who were recovering from Delta Variant without cardiac-related clinical findings. The native T1 mapping and strain imaging may be a sensitive tool for the noninvasive detection of a subset of patients who are at risk for cardiac sequelae and more prone to myocardial damage in survivors with Delta Variant.

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  • The study had 64% women with a median age of 51 (range, 39-62) years.

    “The study had 64% women with a median age of 51 (range, 39-62) years.”

    From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [102]

    The Results, Population characteristics passage reports 28 women among 44 patients (64%) and a median age of 51 years. It identifies 39–62 years as the interquartile range, not the full age range claimed. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Zhang et al examined cardiovascular complications from 44 patients recovering from the Delta variant versus 25 controls and found that 32% had abnormal findings on cMRI and 20% with evidence of myocarditis.

    “Zhang et al 102 examined cardiovascular complications from 44 patients recovering from the Delta variant versus 25 controls and found that 32% had abnormal findings on cMRI and 20% with evidence of myocarditis.”

    From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [102]

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Research works printed but not linked: 34

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Metadata

Authors
Zhang, L., Wei, X., Wang, H., Jiang, R., Tan, Z., Ouyang, J., Li, X., Lei, C., Liu, H., & Liu, J.
Affiliations
  • Guangzhou Eighth People's Hospital (CN)
  • Guangdong Academy of Medical Sciences (CN)
Corresponding author
  • Liu, Hui
  • Liu, Jinxin
ORCID
Venue
ESC Heart Failure
Publisher
Oxford University Press (OUP)
Published
2022-05-13
Volume
9
Issue
4
Pages
2576-2584
ISSN
2055-5822 (ISSN-L)
DOI
10.1002/ehf2.13971
PMC
PMC9288765
OpenAlex
W4280587626
Cited by
13
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 4
FWCI
2.10
Type
journal article
Language
en
Open access
Licence
Locations
  • ESC Heart Failure (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Natural Science Foundation of Guangdong Province (2020A1515010650)
  • National Natural Science Foundation of China (81974262)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
myocardial injury, myocarditis, native T1 mapping, T2 mapping, extracellular volume, late gadolinium enhancement, myocardial strain, cardiac troponin T, post-COVID-19 recovery, Lake Louise criteria
MeSH terms
COVID-19, SARS-CoV-2, Contrast Media, Female, Gadolinium, Humans, Magnetic Resonance Imaging, Middle Aged, Prospective Studies

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