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European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-Year Follow-Up Outcomes and Differences Across Regions
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Aims: The European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT-R) was set up with the aim of describing the clinical epidemiology and the 1-year outcomes of patients with heart failure (HF) with the added intention of comparing differences between participating countries. Methods and results: The ESC-HF-LT-R is a prospective, observational registry contributed to by 211 cardiology centres in 21 European and/or Mediterranean countries, all being member countries of the ESC. Between May 2011 and April 2013 it collected data on 12 440 patients, 40.5% of them hospitalized with acute HF (AHF) and 59.5% outpatients with chronic HF (CHF). The all-cause 1-year mortality rate was 23.6% for AHF and 6.4% for CHF. The combined endpoint of mortality or HF hospitalization within 1 year had a rate of 36% for AHF and 14.5% for CHF. All-cause mortality rates in the different regions ranged from 21.6% to 36.5% in patients with AHF, and from 6.9% to 15.6% in those with CHF. These differences in mortality between regions are thought reflect differences in the characteristics and/or management of these patients. Conclusion: The ESC-HF-LT-R shows that 1-year all-cause mortality of patients with AHF is still high while the mortality of CHF is lower. This registry provides the opportunity to evaluate the management and outcomes of patients with HF and identify areas for improvement.
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“Each increment of 1 unit in the risk score is associated with a 24% higher HF risk within 5 years.”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [480]
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Cardiologist follow-up and improved outcomes of heart failure: a French nationwide cohort
Baudry, G., Pereira, O., Roubille, F., Villacèque, M., Damy, T., Duarte, K., Tangre, P., & Girerd, N. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf218 · Cited by 28
Repetitive levosimendan treatment in the management of advanced heart failure
Oliva, F. G., Colet, J. C., Fedele, F., Fruhwald, F. M., Gustafsson, F., Kivikko, M., Borbély, A., Pölzl, G., & Tschöpe, C. (2018) · European Heart Journal Supplements · doi:10.1093/eurheartj/suy040 · Cited by 28
Self-citationKapelios, C. J., Lund, L. H., Benson, L., Dahlström, U., Rosano, G. M. C., Hauptman, P. J., & Savarese, G. (2021) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvab079 · Cited by 28
Self-citationChioncel, O. D., Čelutkienė, J., Bělohlávek, J., Kamzola, G., Lainščak, M., Merkely, B. P., Miličić, D., Nessler, J., Ristić, A. D., Sawiełajc, L., et al. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14687 · Cited by 28
Self-citationHeart failure 2016: still more questions than answers
Metra, M., Carubelli, V., Ravera, A., & Coats, A. J. S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.10.060 · Cited by 27
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Santos, P. M., Freire, R. B., Esteban‐Fernández, A., Sobrino, J. L. B., Fernández, C., Somoza, F. J. E., Miguel, C. M., & Vilacosta, I. (2019) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2019.02.004 · Cited by 27
“9%, respectively.(17) In addition, the ESC-HF-LT collected data from 12 440 patients (40.”
BackgroundPredictors of one-year outcomes in chronic heart failure: the portrait of a middle income country
Gioli‐Pereira, L., Marcondes‐Braga, F. G., Bernardez‐Pereira, S., Bacal, F., Fernandes, F., Mansur, A. J., Pereira, A. C., & Krieger, J. E. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1226-9 · Cited by 26
CT-IGFBP-4 as a Novel Prognostic Biomarker in Acute Heart Failure
Konev, A. A., Kharitonov, A. V., Rozov, F. N., Altshuler, E. P., Serebryanaya, D. V., Lassus, J. P. E., Harjola, V., Katrukha, A. G., & Postnikov, A. B. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12590 · Cited by 26
Ricciardi, E., Malfa, G. L., Guglielmi, G., Cenni, E., Micali, M., Corsello, L. M., Lopena, P., Manco, L., Pontremoli, R., Moscatelli, P., et al. (2020) · Internal and Emergency Medicine · doi:10.1007/s11739-020-02304-4 · Cited by 26
Lee, Y., Chiou, W., Hsu, C., Lin, P., Liang, H., Chung, F., Liao, C., Lin, W., & Chang, H. (2020) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaa125 · Cited by 26
Heart Failure Incidence Following ST-Elevation Myocardial Infarction
Costa, R. G., Trêpa, M., Oliveira, M. F., de Frias, A. D., Campinas, A., Luz, A., Santos, M., & Torres, S. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.10.035 · Cited by 28
Reis, J., Teixeira, A. R., Gonçalves, A. V., Moreira, R. I., Pereira‐da‐Silva, T., Timóteo, A. T., & Ferreira, R. C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102935 · Cited by 26
Hyperkalemia in heart failure: Foe or friend?
Rakisheva, A., Marketou, M. E., Сергеевна, К. А., Troyanova‐Shchutskaia, T., & Vardas, P. E. (2020) · Clinical Cardiology · doi:10.1002/clc.23392 · Cited by 29
Abid, L., Charfeddine, S., Kammoun, I., Halima, M. B., Slima, H. B., Drissa, M., Mzoughi, K., Mbarek, D., Riahi, L., Antit, S., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251658 · Cited by 25
“6% and fewer than those of the north African population of the ESC-HF long term registry [7], in which rates were 29.”
BackgroundResultInfluentialTay, W. T., Teng, T. K., Simon, O., Ouwerkerk, W., Tromp, J., Doughty, R. N., Richards, A. M., Hung, C., Qin, Y., Aung, T., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021414 · Cited by 25
Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure
Wang, A., Zhao, W., Yan, K., Huang, P., Zhang, H., Zhang, Z., Zhang, D., & Ma, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.810587 · Cited by 27
Guía ESC 2021 sobre estimulación cardiaca y terapia de resincronización
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.025 · Cited by 28
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Özlek, B., Özlek, E., Ağuş, H. Z., Tekinalp, M., Kahraman, S., Çil, C., Çelik, O., Başaran, Ö., Doğan, V., Kaya, B. C., et al. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.11.001 · Cited by 24
Kapelios, C. J., Bonou, M. S., Malliaras, K. G., Athanasiadi, E., Vakrou, S., Skouloudi, M., Masoura, C., & Barbetseas, J. D. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-09995-z · Cited by 24
Krzesiński, P., Siebert, J., Jankowska, E. A., Banasiak, W., Piotrowicz, K., Stańczyk, A., Galas, A. A., Walczak, A., Murawski, P., Chrom, P., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13330 · Cited by 32
Insights into the European Heart Failure Epidemiology
Seferovic, P. M., Polovina, M. M., Savarese, G., Milinković, I., Stanisavljevic, D. M., Lund, L. H., Chioncel, O., Abdelhamid, M., Lopatin, Y. M., Störk, S., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3710 · Cited by 26
Self-citationCarubelli, V., Lombardi, C., Specchia, C., Peveri, G., Oriecuia, C., Tomasoni, D., Pasquale, M. D., Inciardi, R. M., Garrafa, E., & Metra, M. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13223 · Cited by 23
Self-citationPoelzl, G., Egelseer-Bruendl, T., Pfeifer, B. E., Modre‐Osprian, R., Welte, S., Fetz, B., Krestan, S., Haselwanter, B., Zaruba, M., Doerler, J., et al. (2021) · Clinical Research in Cardiology · doi:10.1007/s00392-021-01912-0 · Cited by 23
Gerbaud, É., de la Poterie, A. B., Baudinet, T., Montaudon, M., Beauvieux, M.-C., Lemaître, A.-I., Cetran, L., Séguy, B., Picard, F., Vélayoudom, F.-L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061549 · Cited by 24
Batra, G., Aktaa, S., Benson, L., Dahlström, U., Hage, C., Savarese, G., Vaško, P., Gale, C. P., & Lund, L. H. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2725 · Cited by 23
Self-citationTerhoch, C. B., Moreira, H. F., Ayub‐Ferreira, S. M., Conceição‐Souza, G. E., Salemi, V. M. C., Chizzola, P. R., de Oliveira, M. T., Lage, S. G., Bocchi, E. A., & Issa, V. S. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006207 · Cited by 23
Bajraktari, G., Pugliese, N. R., D’Agostino, A., Rosa, G. M., Ibrahimi, P., Përçuku, L., Miccoli, M., Galeotti, G. G., Fabiani, I., Pedrinelli, R., et al. (2018) · Cardiology Research and Practice · doi:10.1155/2018/3139861 · Cited by 23
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Exercise Training in Heart Failure: Current Evidence and Future Directions
Eleyan, L., Gonnah, A. R., Farhad, I., Labib, A., Varia, A., Eleyan, A., Almehandi, A., Al-Naseem, A., & Roberts, D. H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020359 · Cited by 22
CHECK-HF investigators, Linssen, G. C. M., Veenis, J. F., Rocca, H. B., van Pol, P. E. J., Engelen, D. J., van Tooren, R., Koornstra-Wortel, H. J. J., Hoes, A. W., & Brugts, J. J. (2020) · Netherlands Heart Journal · doi:10.1007/s12471-020-01421-1 · Cited by 21
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“Loop diuretics activate the sympathetic nerve activity and the renin–angiotensin– aldosterone system, which leads to retention of sodium and water in patients with HF.23 Cooper et al. showed that nonpotassium-sparing diuretic usage was associated with arrhythmic death in patients with LV dysfunction.24 In addition, so…”
BackgroundInfluential
Metadata
- Authors
- Crespo-Leiro, M. G., Anker, S. D., Maggioni, A. P., Coats, A. J., Filippatos, G., Ruschitzka, F., Ferrari, R., Piepoli, M. F., Delgado Jimenez, J. F., Metra, M., Fonseca, C., Hradec, J., Amir, O., Logeart, D., Dahlström, U., Merkely, B., Drozdz, J., Goncalvesova, E., Hassanein, M., Chioncel, O., Lainscak, M., Seferovic, P. M., Tousoulis, D., Kavoliuniene, A., Fruhwald, F., Fazlibegovic, E., Temizhan, A., Gatzov, P., Erglis, A., Laroche, C., & Mebazaa, A.
- Affiliations
- Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna, CHUAC , La Coruna ,
- Universitätsmedizin Göttingen (DE)
- European Society of Cardiology (FR)
- University of Warwick (GB)
- University General Hospital Attikon (GR)
- University of Zurich (CH)
- University of Ferrara (IT)
- Azienda Unità Sanitaria Locale Piacenza (IT)
- Cardiology Department, University Hospital 12 de Octubre , Madrid ,
- University of Brescia (IT)
- Heart Failure Unit, S Francisco Xavier Hospital/CHLO NOVA Medical School, Faculdade de Ciências Medicas, Universidade Nova de Lisboa
- Charles University (CZ)
- Bar-Ilan University (IL)
- Inserm (FR)
- Linköping University (SE)
- Semmelweis University, Heart Centre , Budapest ,
- Department of Cardiology, Medical University of Lodz , Lodz ,
- Department of Heart Failure/Transplantation, National Cardiovascular Institute , Bratislava ,
- Alexandria University (EG)
- Carol Davila University of Medicine and Pharmacy (RO)
- Department of Cardiology, General Hospital Celje , Celje ,
- University of Belgrade (RS)
- National and Kapodistrian University of Athens (GR)
- Department of Cardiology, Lithuanian University of Health Sciences , Kaunas ,
- Medical University of Graz (AT)
- Department of Internal Medicine, Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
- Türkiye Yüksek İhtisas Hastanesi (TR)
- Lozenetz Hospital (BG)
- Pauls Stradins Clinical University Hospital , Riga ,
- ORCID
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-01
- Volume
- 18
- Issue
- 6
- Pages
- 613-625
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2465883722
- Cited by
- 798
- References
- 26
- Citations by year
- 2026: 54 · 2025: 88 · 2024: 88 · 2023: 108 · 2022: 97 · 2021: 79 · 2020: 92 · 2019: 61 · 2018: 65 · 2017: 52 · 2016: 13
- FWCI
- 52.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- RUC (Universidade Da Coruña) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- ESC.
- Abbott Vascular International (2011-2014)
- Amgen (2012-2015)
- AstraZeneca (2014-2017)
- Bayer (2013-2018)
- Boehringer Ingelheim (2013-2016)
- Boston Scientific (2010-2012)
- The Bristol Myers Squibb
- Pfizer Alliance (2014-2016)
- The Alliance Daiichi Sankyo Europe GmbH
- Eli Lilly and Company (2014-2017)
- Gedeon Richter Plc. (2014-2017)
- Menarini Int. Op. (2010-2012)
- MSD-Merck and Co. (2011-2014)
- Novartis Pharma AG (2014-2017)
- ResMed (2014-2016)
- Sanofi (2010-2011)
- SERVIER (2012-2015)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure, acute heart failure, chronic heart failure, all-cause mortality, one-year outcomes, heart failure hospitalization, regional variation in mortality, clinical epidemiology
- MeSH terms
- Acute Disease, Aged, Aged, 80 and over, Ambulatory Care, Cardiology, Cause of Death, Chronic Disease, Europe, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Mortality, Prospective Studies, Registries, Societies, Medical, Comorbidity
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