The DOI matches its Crossref record.
Interleukin 6 is involved in interleukin 1‐induced activities
Abstract
Human monocytes produce a number of soluble mediators involved in regulation of inflammation and lymphocyte growth and differentiation such as interleukin 1 (IL1) and tumor necrosis factor. Recently, the cDNA of another monocyte‐derived factor, interleukin 6 (IL6), was cloned. Herein we show that purified E. coli‐derived recombinant IL6 (rIL6) is as active as IL 1 in the thymocyte assay. In addition, IL 1 and IL 6 synergize strongly in stimulating thymocyte proliferation. Another property shared by IL 1 and IL6 is their pyrogenicity. Human rIL6 induces a monophasic fever after i.v. injection into rabbits. Together with the observation that IL 1 induces IL6 in a variety of cells including thymocytes, our data suggest that IL6 is involved in many of the pleiotropic effects of IL1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
“Since IL-1 can induce IL-6 production in fibroblasts, thymocytes, and monocytes (34-36), it is, for example, possible that the partial inhibition of ID6 production is the result of reduced Ibl production.”
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V, Yudkin, J. S., Humphries, S., & Woo, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2629 · Cited by 2,243
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282
Metadata
- Authors
- Helle, M., Brakenhoff, J. P. J., Groot, E. R. D., & Aarden, L. A.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1988-06
- Volume
- 18
- Issue
- 6
- Pages
- 957-959
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2007246198
- Cited by
- 409
- References
- 0
- FWCI
- 26.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interleukin 6 is involved in interleukin 1‐induced activities. https://app.cochat.ai/papers/10.1002/eji.1830180619
- The paper
- Helle, M., Brakenhoff, J. P. J., Groot, E. R. D., & Aarden, L. A. (1988). Interleukin 6 is involved in interleukin 1‐induced activities. European Journal of Immunology. https://doi.org/10.1002/eji.1830180619
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
