Interleukin-6 and the acute phase response

Heinrich, P C; Castell, J V; Andus, T

doi:10.1042/bj2650621

Cited by 2,734Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic DiseasesImmune Response and Inflammation

Interleukin-6 and the acute phase response

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Heinrich, P C, Castell, J V, Andus, T·1990·Biochemical Journal

DOI 10.1042/bj2650621PMC PMC1133681

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Research Article| February 01 1990 Interleukin-6 and the acute phase response P C Heinrich; P C Heinrich *Institut für Biochemie der RWTH Aachen, Pauwelsstraße, 5100 Aachen, Federal Republic of Germany. Search for other works by this author on: This Site PubMed Google Scholar J V Castell; J V Castell †Unidad de Hepatologia Experimental, Centro de Investigación, Hospital La Fe, Avenida de Campanar 21, 46009 Valencia, Spain Search for other works by this author on: This Site PubMed Google Scholar T Andus T Andus ‡Medizinische Universitätsklinik Freiburg, Hugstetter Straße 55, 7800 Freiburg, Federal Republic of Germany Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1990 London: The Biochemical Society1990 Biochem J (1990) 265 (3): 621–636. https://doi.org/10.1042/bj2650621 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation P C Heinrich, J V Castell, T Andus; Interleukin-6 and the acute phase response. Biochem J 1 February 1990; 265 (3): 621–636. doi: https://doi.org/10.1042/bj2650621 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.

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In the liver, IL-6 activates multiple signaling pathways that culminate in the induction of genes involved in growth, hepatocyte-specific metabolic functions, and the acute-phase response.
“In the liver, IL-6 activates multiple signaling pathways that culminate in the induction of genes involved in growth, hepatocyte-specific metabolic functions, and the acute-phase response (13).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [13]
The section on IL-6-responsive elements in acute-phase protein genes reports IL-6-induced gene transcription, and the Actions section describes increased acute-phase protein synthesis in human hepatocytes. But the Signal transduction section says the underlying mechanisms were still unknown; the cited passages do not establish multiple signaling pathways or induction of genes for hepatocyte growth and specific metabolic functions. Page numbers are unavailable in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Late APP genes clustered and were mostly induced upon hIL-6 treatment.
“Hierarchical clustering of significantly regulated genes and further APP genes of interest (Heinrich et al., 1990) revealed that especially late APP genes clustered and were mostly induced upon hIL-6 treatment (Figure 2C).”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Heinrich et al., 1990
The hepatic acute phase response is largely regulated at the transcriptional level.
“the hepatic acute phase response is largely regulated at the transcriptional level”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Heinrich et al., 1990

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The human haptoglobin gene: transcriptional regulation during development and acute phase induction
Oliviero, S., Morrone, G., & Cortese, R. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02450.x · Cited by 123 · see citing works

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Background
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Authors: Heinrich, P. C., Castell, J. V., & Andus, T.
Affiliations: RWTH Aachen University (DE)
Hospital Universitari i Politècnic La Fe (ES)
University of Freiburg (DE)
ORCID: Castell, J V
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1990-02-01
Volume: 265
Issue: 3
Pages: 621-636
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2650621
PMC: PMC1133681
OpenAlex: W1855316965
Cited by: 2,734
References: 2
Citations by year: 2026: 26 · 2025: 50 · 2024: 50 · 2023: 54 · 2022: 67 · 2021: 79 · 2020: 93 · 2019: 54 · 2018: 72 · 2017: 82 · 2016: 81 · 2015: 67 · 2014: 88 · 2013: 84 · 2012: 86
FWCI: 15.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: interleukin-6, acute phase response, cytokines, acute phase proteins, inflammation, liver
MeSH terms: Acute-Phase Proteins, Acute-Phase Reaction, Animals, Base Sequence, Humans, Inflammation, Liver, Molecular Sequence Data, Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Rats

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Interleukin-6 and the acute phase response

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