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Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E
Abstract
Proteolytic degradation (processing) of antigen by antigen‐presenting cells is a major regulatory step in the activation of a T lymphocyte immune response. However, the enzymes responsible for antigen processing remain largely undefined. In this study we show that cathepsin E, and not the ubiquitous lysosomal cathepsin D, is the major aspartic proteinase in a murine antigen‐presenting cell line, A20. Thisenzyme is localized to a non‐lysosomal compartment of the endosomal system in these cells. Functional studies using a highly specific inhibitor of cathepsin E show that this enzyme is essential for the processing of ovalbumin by this cell line. Thus, cathepsin E, whose function was hitherto unknown, may play a major role in antigen processing.
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Citations
Cited by
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY
Chapman, H. A., Riese, R. J., & Shi, G.-P. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.63 · Cited by 786
Nakagawa, T. Y., Brissette, W. H., Lira, P. D., Griffiths, R. J., Petrushova, N., Stock, J., McNeish, J. D., Eastman, S. E., Howard, E. D., Clarke, S. R. M., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80021-7 · Cited by 416
Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
Dunn, B. M. (2002) · Chemical Reviews · doi:10.1021/cr010167q · Cited by 372
Sellers, R. S., Clifford, C. B., Treuting, P. M., & Brayton, C. (2012) · Veterinary Pathology · doi:10.1177/0300985811429314 · Cited by 278
Watts, C. (2004) · Nature Immunology · doi:10.1038/ni1088 · Cited by 259
Metadata
- Authors
- Bennett, K., Levine, T., Ellis, J. S., Peanasky, R. J., Michael Samloff, I., Kay, J., & Chain, B. M.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1992-06
- Volume
- 22
- Issue
- 6
- Pages
- 1519-1524
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2109344094
- Cited by
- 203
- References
- 0
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E. https://app.cochat.ai/papers/10.1002/eji.1830220626
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- Bennett, K., Levine, T., Ellis, J. S., Peanasky, R. J., Michael Samloff, I., Kay, J., & Chain, B. M. (1992). Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E. European Journal of Immunology. https://doi.org/10.1002/eji.1830220626
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
