The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY
Abstract
▪ Abstract Cysteine proteases have traditionally been viewed as lysosomal mediators of terminal protein degradation. However, recent findings refute this limited view and suggest a more expanded role for cysteine proteases in human biology. Several newly discovered members of this enzyme class are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology. These roles appear to include apoptosis, MHC class II immune responses, prohormone processing, and extracellular matrix remodeling important to bone development. The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema. The development of inhibitors of specific cysteine proteases promises to provide new drugs for modifying immunity, osteoporosis, and chronic inflammation.
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Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.1.256 · Cited by 347
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Shen, L., Sigal, L. J., Boes, M., & Rock, K. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.004 · Cited by 391
Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation
Reing, J. E., Zhang, L., Myers-Irvin, J., Cordero, K. E., Freytes, D. O., Heber-Katz, E., Bedelbaeva, K., McIntosh, D., Dewilde, A., Braunhut, S. J., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0425 · Cited by 387
House dust mite allergens in asthma and allergy
Thomas, W. R., Hales, B. J., & Smith, W.-A. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.008 · Cited by 239
Gilchrest, B. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/skinbio.2013.176 · Cited by 215
Metadata
- Authors
- Chapman, H. A., Riese, R. J., & Shi, G.-P.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 59
- Issue
- 1
- Pages
- 63-88
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2111066407
- Cited by
- 786
- References
- 1
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY. https://app.cochat.ai/papers/10.1146/annurev.physiol.59.1.63
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- Chapman, H. A., Riese, R. J., & Shi, G.-P. (1997). EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.59.1.63
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
