Anti‐arthritic effects demonstrated by an interleukin‐2 receptor‐targeted cytotoxin (DAB 486 IL‐2) in rat adjuvant arthritis

Bacha, Patricia; Forte, Serene E.; Perper, Stuart J.; Trentham, David E.; Nichols, Jean C.

doi:10.1002/eji.1830220702

Anti‐arthritic effects demonstrated by an interleukin‐2 receptor‐targeted cytotoxin (DAB 486 IL‐2) in rat adjuvant arthritis

DAB 486 IL‐2 is an interleukin‐2 receptor‐specific cytotoxin which selectively targets and kills cells which bear the high‐affinity form of the IL‐2 receptor. Since elimination of activated T lymphocytes may be useful in the treatment of rheumatoid arthritis, the effect of DAB 486 IL‐2 treatment …