The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.
Open accessAbstract
Several isolates of human T-cell leukemia/lymphoma virus (HTLV) were transmitted to normal human T cells obtained from the umbilical cord blood of newborns. T cells from seven specimens were immortalized by infection with different HTLV isolates and their properties were compared with those of activated uninfected normal T cells grown in the presence of T-cell growth factor (TCGF) and with those of HTLV-positive neoplastic T-cell lines derived from patients with T-cell malignancies. The HTLV-infected cells generally belonged to a class of mature T cells (OKT4+ and Leu 3A+) and differed from the normal uninfected cells in that they could be propagated in culture indefinitely; possessed altered morphology, including convoluted nuclei and some bi- and multinucleated giant cells; formed large clumps in culture; demonstrated a diminished requirement for TCGF; had an increased density of TCGF receptors; often became completely independent of exogenous TCGF; and expressed HLA-DR determinants. These properties of the HTLV-infected cord blood T cells contrasted to those of uncultured cord blood T cells and of cord blood cells stimulated with mitogen and grown with TCGF but resembled the characteristics of T-cell lines established previously from patients with HTLV-associated T-cell malignancies. This in vitro system offers a unique opportunity to study the basic mechanism involved in abnormal growth and neoplastic transformation of a specific class of human T cells.
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Self-citationSelective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows
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Self-citationIsolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)
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Self-citationADULT T-CELL LYMPHOMA-LEUKAEMIA IN BLACKS FROM THE WEST INDIES
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Cited by
Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)
Gallo, R. C., Sarin, P. S., Gelmann, E. P., Robert-Guroff, M., Richardson, E., Kalyanaraman, V. S., Mann, D., Sidhu, G. D., Stahl, R. E., Zolla-Pazner, S., et al. (1983) · Science · doi:10.1126/science.6601823 · Cited by 1,238
Self-citationSodroski, J. G., Rosen, C. A., & Haseltine, W. A. (1984) · Science · doi:10.1126/science.6330891 · Cited by 770
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
Migone, T.-S., Lin, J.-X., Cereseto, A., Mulloy, J. C., O'Shea, J. J., Franchini, G., & Leonard, W. J. (1995) · Science · doi:10.1126/science.7604283 · Cited by 557
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
Felber, B. K., Paskalis, H., Kleinman-Ewing, C., Wong-Staal, F., & Pavlakis, G. N. (1985) · Science · doi:10.1126/science.2992082 · Cited by 516
The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice
Nerenberg, M., Hinrichs, S. H., Reynolds, R. K., Khoury, G., & Jay, G. (1987) · Science · doi:10.1126/science.2888190 · Cited by 510
Metadata
- Authors
- Popovic, M., Lange-Wantzin, G., Sarin, P. S., Mann, D., & Gallo, R. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-09
- Volume
- 80
- Issue
- 17
- Pages
- 5402-5406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2056067293
- Cited by
- 342
- References
- 24
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Popovic, M., Lange-Wantzin, G., Sarin, P. S., Mann, D., & Gallo, R. C. (1983). Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.17.5402
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