The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice
Abstract
Numerous investigations have demonstrated that T cells are involved in destruction of β cells in the NOD mouse, a widely studied model of type I diabetes. In this report we describe a series of islet‐specific T cell lines established from islet‐infiltrating lymphocytes obtained from individual pre‐diabetic NOD mice as well as a large panel of clones derived from these lines. Proliferation assays indicated that these nominally islet‐specific lines responded vigorously to porcine insulin. Furthermore, of 40 islet‐specific clones derived from lines established from 12‐week‐old mice, 22 (55%) responded to insulin. A similar analysis of islet‐specific clones established from 7‐week‐old mice indicated that 2 of 14 (14%) were insulin specific. These findings demonstrate that insulin‐specific T cells can comprise a major portion of the spontaneously arising T cell response to islets in NOD mice.
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Cites
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The structure and evolution of the two nonallelic rat preproinsulin genes
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Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice
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Cited by
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L., Wegmann, D. R., Hutton, J. C., Elliott, J. F., et al. (2005) · Nature · doi:10.1038/nature03523 · Cited by 758
Self-citationKent, S. C., Chen, Y., Bregoli, L., Clemmings, S. M., Kenyon, N. S., Ricordi, C., Hering, B. J., & Hafler, D. A. (2005) · Nature · doi:10.1038/nature03625 · Cited by 409
Daniel, D., & Wegmann, D. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.956 · Cited by 406
Self-citationDaniel, D., Gill, R. G., Schloot, N., & Wegmann, D. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250430 · Cited by 358
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Metadata
- Authors
- Wegmann, D. R., Norbury‐Glaseru, M., & Danielf, D.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1994-08
- Volume
- 24
- Issue
- 8
- Pages
- 1853-1857
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2064671266
- Cited by
- 279
- References
- 24
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wegmann, D. R., Norbury‐Glaseru, M., & Danielf, D. (1994). Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice. European Journal of Immunology. https://doi.org/10.1002/eji.1830240820
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
