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Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell Clone
Abstract
Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4 + islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.
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Citations
Cited by
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S., Eagar, T. N., & Forsthuber, T. G. (2015) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,160
Following a diabetogenic T cell from genesis through pathogenesis
Katz, J. D., Wang, B., Haskins, K., Benoist, C., & Mathis, D. (1993) · Cell · doi:10.1016/0092-8674(93)90730-e · Cited by 696
Self-citationThe Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD
Delovitch, T. L., & Singh, B. (1997) · Immunity · doi:10.1016/s1074-7613(00)80392-1 · Cited by 676
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Metadata
- Authors
- Haskins, K., & McDuffie, M.
- Venue
- Science
- Published
- 1990-09-21
- Volume
- 249
- Issue
- 4975
- Pages
- 1433-1436
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058794781
- Cited by
- 382
- References
- 0
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell Clone. https://app.cochat.ai/papers/10.1126/science.2205920
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- Haskins, K., & McDuffie, M. (1990). Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell Clone. Science. https://doi.org/10.1126/science.2205920
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
