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Induction of natural killer cell migration by monocyte chemotactic protein−1, −2 and −3
Abstract
Under certain physiological and pathological conditions, naturall killer (NK) cells rapidly accumulate in tissues. Chemokines are an essential component of the current paradigm of leukocyte recruitment. The present study was designed to investigate the responsiveness of NK cells to the prototypic C‐C chemokine, monocyte chemotactic protein‐1 (MCP‐1). MCP‐1 induced migration across filters of interleukin (IL)‐2‐activated NK cells, whereas it was a weak attractant for unstimulated cells. Maximal induction of migration required a positive concentration gradient between the lower and the upper compartment of the chemotaxis chamber. Preliminary characterization of the MCP‐1 receptor on NK cells indicated that the chemotactic response to MCP‐1 was blocked by pre‐treatment of cells with Bordetella pertussis toxin, and MCP‐1 but not IL‐8 displaced 125 I‐labeled MCP‐1 from IL‐2‐activated NK cells. The related chemokines MCP‐2 and MCP‐3 were also active – though less potent – attractants for activated NK cells. Thus the spectrum of action of MCP‐1, ‐2 and ‐3 encompasses NK cells and chemokines are likely to play a role in regulating extravasation of these cells.
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Citations
Cited by
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis
Gschwandtner, M., Derler, R., & Midwood, K. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02759 · Cited by 611
Negus, R. P., Stamp, G. W., Relf, M. G., Burke, F., Malik, S. T., Bernasconi, S., Allavena, P., Sozzani, S., Mantovani, A., & Balkwill, F. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117933 · Cited by 315
Self-citationDendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity
Zitvogel, L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012040 · Cited by 268
Morrison, B. E., Park, S. J., Mooney, J. M., & Mehrad, B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18125 · Cited by 234
CC chemokines induce the generation of killer cells from CD56+ cells
Maghazachi, A. A., Al‐Aoukaty, A., & Schall, T. J. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260207 · Cited by 163
Metadata
- Authors
- Allavena, P., Bianchi, G., Zhou, D., Van Damme, J., Jílek, P., Sozzani, S., & Mantovani, A.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 24
- Issue
- 12
- Pages
- 3233-3236
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2030411262
- Cited by
- 291
- References
- 0
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Allavena, P., Bianchi, G., Zhou, D., Van Damme, J., Jílek, P., Sozzani, S., & Mantovani, A. (1994). Induction of natural killer cell migration by monocyte chemotactic protein−1, −2 and −3. European Journal of Immunology. https://doi.org/10.1002/eji.1830241249
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