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Cited by 611Chemokine receptors and signalingImmune cells in cancerAdipokines, Inflammation, and Metabolic Diseases

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

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Gschwandtner, Martha, Derler, Rupert, Midwood, Kim S.·2019·Frontiers in Immunology
DOI 10.3389/fimmu.2019.02759PMC PMC6923224
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Abstract

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types both during physiological immune defense and in pathological circumstances, such as autoimmune diseases including rheumatoid arthritis and multiple sclerosis, inflammatory diseases including atherosclerosis, as well as infectious diseases, obesity, diabetes, and various types of cancer. However, new data suggest that the scope of CCL2's functions may extend beyond its original characterization as a chemoattractant. Emerging evidence shows that it can impact leukocyte behavior, influencing adhesion, polarization, effector molecule secretion, autophagy, killing, and survival. The direction of these CCL2-induced responses is context dependent and, in some cases, synergistic with other inflammatory stimuli. The involvement of CCL2 signaling in multiple diseases renders it an interesting therapeutic target, although current targeting strategies have not met early expectations in the clinic. A better understanding of how CCL2 affects immune cells will be pivotal to the improvement of existing therapeutic approaches and the development of new drugs. Here, we provide an overview of the pleiotropic effects of CCL2 signaling on cells of the myeloid lineage, beyond chemotaxis, and highlight how these actions might help to shape immune cell behavior and tumor immunity.

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  • CCL2 influences lipid droplet biosynthesis and pro-inflammatory polarization, and can interact with other inflammatory mediators.

    “CCL2 has been shown to influence LD biosynthesis [71] and pro-inflammatory polarization, and can interact with other inflammatory mediators [72].”

    From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [72]

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Sorted by citations

Authors
Gschwandtner, M., Derler, R., & Midwood, K. S.
Affiliations
  • University of Oxford (GB)
  • University of Graz (AT)
Corresponding author
Midwood, Kim S.
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2019-12-13
Volume
10
Pages
2759-2759
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2019.02759
PMC
PMC6923224
OpenAlex
W3005414324
Cited by
611
References
10
Citations by year
2026: 52 · 2025: 101 · 2024: 101 · 2023: 108 · 2022: 111 · 2021: 98 · 2020: 40
FWCI
5.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Austrian Science Fund
  • Versus Arthritis
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
MCP-1, myeloid cells, chemotaxis, leukocyte adhesion, macrophage polarization, autophagy, cell killing, cell survival, inflammatory diseases, autoimmune disease, antitumor immunity, therapeutic target
MeSH terms
Animals, Cell Communication, Cell Differentiation, Chemotaxis, Gene Expression Regulation, Humans, Macrophage Activation, Macrophages, Signal Transduction, Chemokine CCL2, Myeloid Cells

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