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Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
Abstract
Specialized roles for the pro‐inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LTα−/− and TNF−/− mice established by direct gene targeting of C57BL/6 ES cells. The requirement for LT early in lymphoid tissue organogenesis is shown to be distinct from the more subtle and varied role of TNF in promoting correct microarchitectural organization of leukocytes in LN and spleen. Development of normal Peyer's patch (PP) structure, in contrast, is substantially dependent on TNF. Only mice lacking LT exhibit retarded B cell maturation in vivo and serum immunoglobulin deficiencies. A temporal hierarchy in lymphoid tissue development can now be defined, with LT being an essential participant in general lymphoid tissue organogenesis, developmentally preceeding TNF that has a more varied and subtle role in promotion of correct spatial organization of leukocytes in LN and spleen. PP development in TNF−/− mice is unusual, indicating that TNF is a more critical participant for this structure than it is for other lymphoid tissues.
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
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Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W.-L., et al. (2011) · Nature · doi:10.1038/nature09816 · Cited by 940
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
Kaneko, N., Kuo, H.-H., Boucau, J., Farmer, J. R., Allard-Chamard, H., Mahajan, V. S., Piechocka-Trocha, A., Lefteri, K., Osborn, M., Bals, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.025 · Cited by 734
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
Kara, E. E., McKenzie, D. R., Bastow, C. R., Gregor, C. E., Fenix, K. A., Ogunniyi, A. D., Paton, J. C., Mack, M., Pombal, D. R., Seillet, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms9644 · Cited by 136
Popescu, M., Cabrera-Martinez, B., & Winslow, G. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900484 · Cited by 72
Marzano, P., Balin, S., Terzoli, S., Della Bella, S., Cazzetta, V., Piazza, R., Sandrock, I., Ravens, S., Tan, L., Prinz, I., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1208662 · Cited by 13
Metadata
- Authors
- Körner, H., Cook, M., Riminton, D. S., Lemckert, F. A., Hoek, R. M., Ledermann, B., Köntgen, F., de St Groth, B. F., & Sedgwick, J. D.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1997-10
- Volume
- 27
- Issue
- 10
- Pages
- 2600-2609
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2083945266
- Cited by
- 311
- References
- 2
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
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