Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Pfeffer, Klaus; Matsuyama, Toshifumi; Kündig, Thomas M.; Wakeham, Andrew; Kishihara, Kenji; Shahinian, Arda; Wiegmann, Katja; Ohashi, Pamela S.; Krönke, Martin; Mak, Tak W.

doi:10.1016/0092-8674(93)90134-c

Cited by 1,677Immune Response and InflammationNF-κB Signaling PathwaysT-cell and B-cell Immunology

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Pfeffer, Klaus, Matsuyama, Toshifumi, Kündig, Thomas M., Wakeham, Andrew, Kishihara, Kenji, Shahinian, Arda, Wiegmann, Katja, Ohashi, Pamela S. +2 more·1993·Cell

DOI 10.1016/0092-8674(93)90134-c

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Abstract

The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain. Cells from TNFRp55-/-mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules. Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired. However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-kappa B in T lymphocytes from TNFRp55-deficient mice. The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B. In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.

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Authors: Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W.
Affiliations: University of Toronto (CA)
Technical University of Munich (DE)
ORCID: Pfeffer, Klaus
Matsuyama, Toshifumi
Kündig, Thomas M.
Wiegmann, Katja
Ohashi, Pamela S.
Krönke, Martin
Mak, Tak W.
Venue: Cell
Publisher: Elsevier BV
Published: 1993-05
Volume: 73
Issue: 3
Pages: 457-467
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(93)90134-c
OpenAlex: W2009550948
Cited by: 1,677
References: 70
Citations by year: 2026: 3 · 2025: 13 · 2024: 17 · 2023: 9 · 2022: 8 · 2021: 27 · 2020: 24 · 2019: 20 · 2018: 25 · 2017: 27 · 2016: 26 · 2015: 27 · 2014: 32 · 2013: 31 · 2012: 29
FWCI: 36.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Medical Research Council Canada
National Cancer Institute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: endotoxic shock, staphylococcal enterotoxin B, Listeria monocytogenes infection, TNF signaling, NF-κB activation, T cell development, clonal deletion, host defense against bacteria
MeSH terms: Animals, Base Sequence, Cell Nucleus, Cloning, Molecular, Humans, Immunity, Innate, Kinetics, Lipopolysaccharides, Listeriosis, Liver, Lymphocytes, Mice, Mutant Strains, Molecular Sequence Data, Molecular Weight, Oligodeoxyribonucleotides, Radioligand Assay, Receptors, Cell Surface, Shock, Septic, Transfection, Tumor Necrosis Factor-alpha, Polymerase Chain Reaction, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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