The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec‐7‐dependent and ‐independent mechanisms
Abstract
Siglec‐7 is a sialic acid binding receptor with inhibitory potential, expressed on human NK cells and monocytes. It has an unusual binding preference for α2,8‐linked disialic acids, such as those displayed by ganglioside GD3. Here we have investigated whether siglec‐7‐GD3 interactions are able to modulate NK cell cytotoxicity. Using synthetic polyacrylamide glycoprobes, siglec‐7 was found to be masked at the NK cell surface but it could be unmasked by sialidase treatment of NK cells. GD3 synthase‐transfected P815 target cells expressed high levels of GD3 and bound strongly to recombinant siglec‐7‐Fc protein. Surprisingly, GD3 synthase‐transfected P815 cells were killed more effectively by untreated cells in a siglec‐7‐independent manner. However, following sialidase treatment of NK cells, a siglec‐7‐dependent inhibition of killing was observed. These findings have important implications for NK cell cytotoxicity against tumor cells like melanoma that express high levels of GD3 ganglioside.
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Cites
Okada, M., Itoh, M.-I., Haraguchi, M., Okajima, T., Inoue, M., Oishi, H., Matsuda, Y., Iwamoto, T., Kawano, T., Fukumoto, S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100395200 · Cited by 179
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Cited by
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
Siglec-mediated regulation of immune cell function in disease
Macauley, M. S., Crocker, P. R., & Paulson, J. C. (2014) · Nature Reviews Immunology · doi:10.1038/nri3737 · Cited by 1,122
Self-citationGlycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
Hudak, J. E., Canham, S. M., & Bertozzi, C. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1388 · Cited by 485
Siglecs as Immune Cell Checkpoints in Disease
Duan, S., & Paulson, J. C. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102419-035900 · Cited by 452
Gangliosides in cell recognition and membrane protein regulation
Lopez, P. H., & Schnaar, R. L. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.06.001 · Cited by 311
Metadata
- Authors
- Nicoll, G., Avril, T., Lock, K., Furukawa, K., Bovin, N., & Crocker, P. R.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2003-05-19
- Volume
- 33
- Issue
- 6
- Pages
- 1642-1648
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2096549417
- Cited by
- 245
- References
- 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nicoll, G., Avril, T., Lock, K., Furukawa, K., Bovin, N., & Crocker, P. R. (2003). Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec‐7‐dependent and ‐independent mechanisms. European Journal of Immunology. https://doi.org/10.1002/eji.200323693
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